Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

Loss of coiled-coil protein Cep55 impairs neural stem cell abscission and results in p53-dependent apoptosis in developing cortex

(2021) Jessica N. Little et al.   JOURNAL OF NEUROSCIENCE

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis

(2021) Chun-Che Tseng et al.   JOURNAL OF CELL BIOLOGY

Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy

(2020) Jian Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDCD6IP , encoding a regulator of the ESCRT complex, is mutated in microcephaly

(2020) Amjad Khan et al.   CLINICAL GENETICS

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis

(2020) Cyril Addi et al.   Nature Communications

Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions

(2020) Antonio Tedeschi et al.   Nature Communications

Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells

(2020) Shu‐Li Lin et al.   FEBS Open Bio

Nuclear hubs built on RNAs and clustered organization of the genome

(2020) Kelly P. Smith et al.   CURRENT OPINION IN CELL BIOLOGY

Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids

(2020) Ruben D. Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SON and SRRM2 are essential for nuclear speckle formation

(2020) İbrahim Avşar Ilik et al.   eLife

An ATM–Chk2–INCENP pathway activates the abscission checkpoint

(2020) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

(2019) Rahul Bhowmick et al.   CURRENT BIOLOGY

Building bridges between chromosomes: novel insights into the abscission checkpoint

(2019) Eleni Petsalaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission

(2019) Eva P. Karasmanis et al.   CURRENT BIOLOGY

Genome organization around nuclear speckles

(2019) Yu Chen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The ESCRT-machinery: closing holes and expanding roles

(2019) Alberto T Gatta et al.   CURRENT OPINION IN CELL BIOLOGY

The liquid nucleome – phase transitions in the nucleus at a glance

(2019) Amy R. Strom et al.   JOURNAL OF CELL SCIENCE

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

(2019) Luisa Capalbo et al.   Nature Communications

Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis

(2018) Maria Dandoulaki et al.   JOURNAL OF CELL BIOLOGY

Kinase-controlled phase transition of membraneless organelles in mitosis

(2018) Arpan Kumar Rai et al.   NATURE

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

(2018) Jessica B. A. Sadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding

(2016) Sheng Sun et al.   DEVELOPMENTAL CELL

ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission

(2016) Liliane Christ et al.   JOURNAL OF CELL BIOLOGY

Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier

(2016) Yvan Campos et al.   Nature Communications

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint

(2016) Eleni Petsalaki et al.   Nature Communications

Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis

(2016) Luisa Capalbo et al.   Open Biology

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission

(2015) Douglas R. Mackay et al.   MOLECULAR BIOLOGY OF THE CELL

Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis

(2015) J Jeffery et al.   ONCOGENE

Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing

(2015) Shinsuke Araki et al.   PLoS One

ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

(2015) Anna Caballe et al.   eLife

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

(2014) Sigrid B. Thoresen et al.   NATURE CELL BIOLOGY

Condensin and the Spindle Midzone Prevent Cytokinesis Failure Induced by Chromatin Bridges in C. elegans Embryos

(2013) Joshua N. Bembenek et al.   CURRENT BIOLOGY

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

(2013) Paul D P Pharoah et al.   NATURE GENETICS

ESCRT-III Assembly and Cytokinetic Abscission Are Induced by Tension Release in the Intercellular Bridge

(2013) J. Lafaurie-Janvore et al.   SCIENCE

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2

(2012) Noriko Saitoh et al.   MOLECULAR BIOLOGY OF THE CELL

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis

(2012) L. Capalbo et al.   Open Biology

Activation of the Retroviral Budding Factor ALIX

(2011) Q. Zhai et al.   JOURNAL OF VIROLOGY

Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes

(2011) B. Hegemann et al.   Science Signaling

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission

(2010) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint

(2010) Douglas R. Mackay et al.   JOURNAL OF CELL BIOLOGY

Son Is Essential for Nuclear Speckle Organization and Cell Cycle Progression

(2010) Alok Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Biochemical Analyses of Human IST1 and Its Function in Cytokinesis

(2009) Monika Bajorek et al.   MOLECULAR BIOLOGY OF THE CELL

Essential Role of hIST1 in Cytokinesis

(2009) Monica Agromayor et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanism for chromosome segregation sensing by the NoCut checkpoint

(2009) Manuel Mendoza et al.   NATURE CELL BIOLOGY

Differential dynamics of splicing factor SC35 during the cell cycle

(2008) Kaushlendra Tripathi et al.   JOURNAL OF BIOSCIENCES

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release

(2008) J. G. Carlton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55

(2008) H. H. Lee et al.   SCIENCE