Review
Endocrinology & Metabolism
Johnny S. Younis, Karl Skorecki, Zaid Abassi
Summary: COVID-19 is a complex disease involving various health and disease mechanisms. Sex hormones like estrogen and testosterone play significant roles in its pathogenesis and development, while factors such as age, gender, and ethnic background may also impact disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Kristina Groti Antonic, Blaz Antonic, Monica Caliber, Sandeep Dhindsa
Summary: Men have more severe Covid-19 outcomes and higher mortality rates than women, but testosterone levels may not play a significant role. Studies show that testosterone concentrations in men during acute Covid-19 are inversely proportional to inflammation and illness severity.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
W. Vena, A. Pizzocaro, G. Maida, M. Amer, A. Voza, A. Di Pasquale, F. Reggiani, M. Ciccarelli, C. Fedeli, D. Santi, E. Lavezzi, A. G. Lania, G. Mazziotti
Summary: Hypogonadism is common in male patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Low testosterone (T) levels are associated with unfavorable outcomes of COVID-19, and further prospective studies are needed to evaluate the long-term outcomes of hypogonadism related to COVID-19 and the clinical impact of T replacement during and after acute illness.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Oncology
Astha Thakkar, Jesus D. Gonzalez-Lugo, Niyati Goradia, Radhika Gali, Lauren C. Shapiro, Kith Pradhan, Shafia Rahman, So Yeon Kim, Brian Ko, R. Alejandro Sica, Noah Kornblum, Lizamarie Bachier-Rodriguez, Margaret McCort, Sanjay Goel, Roman Perez-Soler, Stuart Packer, Joseph Sparano, Benjamin Gartrell, Della Makower, Yitz D. Goldstein, Lucia Wolgast, Amit Verma, Balazs Halmos
Summary: Most cancer patients show high seroconversion rates after receiving COVID-19 vaccines, but those with hematologic malignancies, especially after highly immunosuppressive therapies, exhibit lower conversion rates. Patients on immune checkpoint inhibitor therapy or hormonal therapy display high conversion rates.
Article
Biochemistry & Molecular Biology
Lorenzo Marinelli, Guglielmo Beccuti, Marco Zavattaro, Serena Cagnina, Iacopo Gesmundo, Chiara Bona, Chiara Lopez, Silvia Scabini, Francesca Canta, Simone Mornese Pinna, Tommaso Lupia, Cataldo Di Bisceglie, Federico Ponzetto, Fabio Settanni, Francesco Giuseppe De Rosa, Ezio Ghigo, Giovanna Motta
Summary: This study evaluated the hypothalamic-pituitary-gonadal axis in men admitted with SARS-CoV-2 pneumonia and found that testosterone levels were associated with adverse clinical outcomes. Short-term changes in hormone levels may be related to functional recovery of steroidogenesis and improvement in spermatozoa functional status.
Article
Gastroenterology & Hepatology
Jean-Francois Dufour, Thomas Marjot, Chiara Becchetti, Herbert Tilg
Summary: Knowledge on the effects of SARS-CoV-2 infection and COVID-19 in liver diseases has rapidly increased during the pandemic. Patients with chronic liver disease, especially decompensated cirrhosis, are at a higher risk for severe COVID-19 and death. Liver transplantation was impacted due to concerns about donation and infection in recipients, but did not contribute to worse outcomes. Limited data suggests that specific therapy for COVID-19 in liver transplant recipients may be promising. The immune response induced by COVID-19 vaccines seems to be impaired in patients with chronic liver disease and liver transplant recipients, suggesting a need for revised vaccination schedules in this population.
Article
Multidisciplinary Sciences
Kenji Nakamichi, Jolie Z. Shen, Cecilia S. Lee, Aaron Lee, Emma A. Roberts, Paul D. Simonson, Pavitra Roychoudhury, Jessica Andriesen, April K. Randhawa, Patrick C. Mathias, Alex L. Greninger, Keith R. Jerome, Russell N. Van Gelder
Summary: The COVID-19 epidemic of 2019-20 is caused by the novel coronavirus SARS-CoV-2, which has infected millions worldwide. This study aimed to determine if SARS-CoV-2 sequence variants are linked to different outcomes among COVID-19 patients in a single medical system. The virus has shown rapid mutation with two major clades of sequence variants identified.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Nobuaki Matsunaga, Kayoko Hayakawa, Mari Terada, Hiroshi Ohtsu, Yusuke Asai, Shinya Tsuzuki, Setsuko Suzuki, Ako Toyoda, Kumiko Suzuki, Mio Endo, Naoki Fujii, Michiyo Suzuki, Sho Saito, Yukari Uemura, Taro Shibata, Masashi Kondo, Kazuo Izumi, Junko Terada-Hirashima, Ayako Mikami, Wataru Sugiura, Norio Ohmagari
Summary: This study in Japan examined hospitalized patients with COVID-19, finding that they are typically middle-aged males with close contact to confirmed or suspected cases. The most common comorbidities were hypertension and diabetes. Most patients admitted were nonsevere cases, with a majority not requiring oxygen support during hospitalization.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Public, Environmental & Occupational Health
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: The study found that low levels of plasma apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) in COVID-19 patients are associated with increased risk of developing severe disease, while the ApoB/ApoA1 ratio does not show a significant association with severity. Additionally, low ApoA1 levels are linked to higher all-cause mortality rates.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Medicine, Research & Experimental
Mohammad Hossein Imanieh, Fatemeh Amirzadehfard, Sina Zoghi, Faezeh Sehatpour, Peyman Jafari, Hamidreza Hassanipour, Maryam Feili, Maryam Mollaie, Pardis Bostanian, Samrad Mehrabi, Reyhaneh Dashtianeh, Afrooz Feili
Summary: This study aimed to develop a predictive scoring model for early detection of high risk COVID-19 patients by analyzing clinical and laboratory data. A simple scoring system incorporating CRP, oxygen saturation variation, PT, diastolic blood pressure, BUN, and LDH was derived. The scoring system can help identify patients at higher risk of mortality.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Immunology
Mohamed Zakaria Bouayed, Ilyass Laaribi, Charaf Eddine Mohammed Chatar, Iliass Benaini, Mohammed Amine Bouazzaoui, Younes Oujidi, Samia Berrichi, Ghizlane El Aidouni, Houssam Bkiyar, Naima Abda, Brahim Housni
Summary: This study aimed to investigate whether CRP levels at admission could predict the progression of COVID-19 patients, showing that patients with CRP levels >= 100mg/L were more likely to have severe lung involvement, require mechanical ventilation, and had a significantly higher mortality rate compared to those with CRP levels < 100mg/L.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
Emmanuel Lafont, Helene Pere, David Lebeaux, Geoffrey Cheminet, Eric Thervet, Romain Guillemain, Adrien Flahault
Summary: This study suggests that targeted treatment for COVID-19, including antiviral drugs or monoclonal antibodies, is safe and effective in immunocompromised patients, especially those at high risk.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Erin M. Bange, Nicholas A. Han, Paul Wileyto, Justin Y. Kim, Sigrid Gouma, James Robinson, Allison R. Greenplate, Madeline A. Hwee, Florence Porterfield, Olutosin Owoyemi, Karan Naik, Cathy Zheng, Michael Galantino, Ariel R. Weisman, Caroline A. G. Ittner, Emily M. Kugler, Amy E. Baxter, Olutwatosin Oniyide, Roseline S. Agyekum, Thomas G. Dunn, Tiffanie K. Jones, Heather M. Giannini, Madison E. Weirick, Christopher M. McAllister, N. Esther Babady, Anita Kumar, Adam J. Widman, Susan DeWolf, Sawsan R. Boutemine, Charlotte Roberts, Krista R. Budzik, Susan Tollett, Carla Wright, Tara Perloff, Lova Sun, Divij Mathew, Josephine R. Giles, Derek A. Oldridge, Jennifer E. Wu, Cecile Alanio, Sharon Adamski, Alfred L. Garfall, Laura A. Vella, Samuel J. Kerr, Justine Cohen, Randall A. Oyer, Ryan Massa, Ivan P. Maillard, Kara N. Maxwell, John P. Reilly, Peter G. Maslak, Robert H. Vonderheide, Jedd D. Wolchok, Scott E. Hensley, E. John Wherry, Nuala J. Meyer, Angela M. DeMichele, Santosha A. Vardhana, Ronac Mamtani, Alexander C. Huang
Summary: In patients with cancer and COVID-19, those with hematologic cancer show impaired immune responses compared to solid cancer patients. CD8 T cells play a crucial role in survival, even in the presence of limited humoral responses. The presence of SARS-CoV-2-specific T cell responses in hematologic cancer patients suggests a potential therapeutic target.
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Respiratory System
Fatih Yildirim, Fahir Ozkalemkas, Ahmet Ursavas
Summary: This study analyzed hemorrhagic complications in thrombocytopenic patients who underwent FOB and received treatment for hematologic malignancy. The results demonstrated that FOB is safe in multidisciplinary centers when performed by experienced pulmonologists.
EGYPTIAN JOURNAL OF BRONCHOLOGY
(2022)
Article
Andrology
Ahmet Emre Cinislioglu, Saban Oguz Demirdogen, Adem Utlu, Tugay Aksakalli, Mehmet Sefa Altay, Fatih Akkas, Ibrahim Karabulut, Isa Ozbey
Summary: This prospective study aimed to investigate the relationship between smartphone screen time and the intravaginal ejaculation latency time (IELT) in patients with acquired PE. The study included 30 patients diagnosed with acquired PE and 30 healthy volunteers as the control group. The results showed that smartphone screen time negatively affected IELT values and PE severity in patients with acquired PE.
Article
Rheumatology
Fatih Yildirim, Mustafa Erdogan, Melek Yalcin Mutlu, Gamze Akkuzu, Duygu Sevinc Ozgur, Bilgin Karaalioglu, Mesut Ayer, Cemal Bes
Summary: VEXAS syndrome, a newly defined disorder, poses challenges regarding treatment options. A case report of a patient with atypical symptoms and an intriguing treatment course is presented. The patient exhibited fatigue, recurring fever, lung infiltrates, proteinuria, anemia, leucopenia, transient skin rash, and elevated acute phase reactants. Corticosteroid tapering was not well tolerated, but rapid recovery was achieved following diagnostic splenectomy, which revealed significant findings upon pathological examination.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Gamze Akkuzu, Selvinaz Ozkara, Duygu Sevinc Ozgur, Bilgin Karaalioglu, Fatih Yildirim, Mesut Ayer, Cemal Bes
Summary: Patients with systemic lupus erythemasus (SLE) are at increased risk of infections, particularly when undergoing immunosuppressive therapy. Leishmaniasis is a parasitic disease caused by Leishmania protozoan parasites. We present a case of a patient with SLE who was also diagnosed with leishmaniasis and showed significant improvement after treatment.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
S. O. Demirdogen, A. E. Cinislioglu, T. Aksakalli, S. Al, B. Kozubaev, F. Akkas, S. Adanur, T. Yapanoglu, Y. Aksoy, I. Ozbey, O. Polat
Summary: This study aimed to determine the timing of contralateral testicular fixation in postpubertal patients with testicular torsion. The results showed that a patient-based approach, prioritizing the clinical characteristics of the patient, can lead to more effective and safe outcomes. This research provides valuable insights for the management of testicular torsion in postpubertal patients.
ACTAS UROLOGICAS ESPANOLAS
(2023)
Article
Urology & Nephrology
T. Aksakalli, S. Adanur, S. O. Demirdogen, O. Polat
Summary: The study investigated the efficacy and safety of the self-expandable Allium(R) ureteral stent in the treatment of ureteral stricture. The results showed that the stent is an effective and reliable minimally invasive treatment option.
ACTAS UROLOGICAS ESPANOLAS
(2023)
Article
Pathology
Elif Guler Kazanci, Yasemin Ustundag, Muberra Akdogan, Fatih Yildirim, Elif Yalcin Arikan, Kagan Huysal
Summary: The study aimed to determine the reference interval of RDW to platelet count ratio (RPR) for premature newborns. By reviewing the medical records of preterm infants between January 2016 and December 2018, it was found that the reference interval for RPR in infants with a gestational age of 28-35 weeks was 0.038-0.126, 0.042-0.129 for infants with a gestational age of 32-35 weeks, and 0.022-0.121 for infants with a gestational age of 28-31 weeks. Conclusion: Establishing the reference interval for RPR in premature infants allows for clinical correlation of RPR alterations in this population.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Rheumatology
Rabia Deniz, Tevfik Guzelbey, Duygu Sevinc Ozgur, Bilgin Karaalioglu, Gamze Akkuzu, Fatih Yildirim, Cemal Bes
Summary: This is a case report of isolated vasculitis of bilateral inferior thyroidal arteries in a 49-year-old female patient. The patient presented with neck pain and was diagnosed with ultrasonography and computed tomographic angiography. The treatment with glucocorticoid induction and addition of methotrexate was successful in managing the clinical and imaging findings. Localized forms of vasculitis are rare and the small size of the affected area makes diagnostic investigations and management more complicated.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Hale Gulcin Yildirim Dogan, Fatih Yildirim, Ozan Cemal Icacan, Melek Yalcin Mutlu, Selda Celik, Cemal Bes
Summary: The study aimed to evaluate the type and frequency of pulmonary involvement in ANCA-associated vasculitis (AAV) and investigate the potential relationship with thorax CT signs and other clinical findings. It was found that lung involvement was detected in almost all patients with AAV, and severe pulmonary involvement was more common in MPO-ANCA positive patients and associated with severe disease. Therefore, pulmonary examination by imaging may be useful for determining vasculitis subtype and disease extent in AAV patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Gamze Akkuzu, Aslan Erdogan, Chanife Moustafa, Rabia Deniz, Duygu Sevinc Ozguer, Bilgin Karaalioglu, Fatih Yildirim, Cemal Bes
Summary: Cardiac involvement is rare in Behcet syndrome, but it can be the first manifestation of the disease. Early diagnosis and initiation of immunosuppressive treatment are crucial for improving the prognosis. Coronary aneurysms can develop spontaneously or as a reaction to vascular intervention, and the risk of restenosis is high without immunosuppressive treatment. We present a case of a young male diagnosed with Behcet syndrome after acute coronary syndrome caused by coronary artery aneurysms and thrombosis.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
Adem Utlu, Fatih Ozkaya, Tugay Aksakalli, Ahmet Emre Cinislioglu, Saban Oguz Demirdogen, Mehmet Sefa Altay, Ibrahim Karabulut, Isa Ozbey, Sibel Guclu Utlu
Summary: This study compared the sperm retrieval rates between unilateral and bilateral microdissection testicular sperm extraction (MD-TESE) procedures in patients with non-obstructive azoospermia (NOA), and compared them with literature data. The results showed no significant difference in terms of sperm availability between the two groups of patients. Considering the operative time and complication rates of bilateral MD-TESE in patients with NOA, as well as possible subsequent MD-TESE procedures, unilateral MD-TESE is considered to be more preferable for this patient group.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Fatih Yildirim, Burak Ucaner, Oguz Hancerliogullari
Summary: This study evaluated the diagnostic performance of CT findings in the histological results of acute appendicitis. The results showed that appendix diameter, heterogeneity in fatty tissue, appendicolith, and appendix wall thickening were determinants in gangrenous appendicitis. Preoperative CT findings can be useful indicators in the diagnosis of gangrenous appendicitis.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
G. Akkuzu, C. Bes, D. S. Ozgur, B. Karaaliolu, M. Y. Mutlu, F. Yildirim, P. Atagunduz, A. Gunduz, M. Soy
Summary: This study investigated the clinical characteristics and laboratory parameters of newly developed autoimmune-inflammatory rheumatic diseases (AIRD) in individuals recently vaccinated for COVID-19. Among the 22 cases vaccinated, 14 cases developed AIRD, with 54.5% of them diagnosed with rheumatoid arthritis. The study suggests that COVID-19 vaccination may lead to the development of AIRD and should be carefully considered in newly diagnosed AIRD patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Fatih Yildirim, Ahmet Yildiz, Mahir Murat Cengiz, Murat Temel, Ayse Kureksiz
Summary: The study investigates the effects of goats on abnormal behaviors in horses. It found that goats have a positive impact on some abnormal behaviors, such as front feet playing, crib-biting objects, and box walking, but not others.
ARCHIVES ANIMAL BREEDING
(2023)
