期刊
GENETICS AND MOLECULAR RESEARCH
卷 15, 期 1, 页码 -出版社
FUNPEC-EDITORA
DOI: 10.4238/gmr.15017502
关键词
Invasive pituitary adenomas; TNF-alpha; IL-6; Immunohistochemistry
The aim of this study was to investigate expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-alpha and IL-6 were found to be upregulated in IPA tissue compared with that of NIPA (P < 0.05). These proteins may therefore play important roles in the occurrence and progression of IPA.
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