Review
Gastroenterology & Hepatology
Eline Margrete Randulff Hillestad, Aina van der Meeren, Bharat Halandur Nagaraja, Ben Rene Bjorsvik, Noman Haleem, Alfonso Benitez-Paez, Yolanda Sanz, Trygve Hausken, Guelen Arslan Lied, Arvid Lundervold, Birgitte Berentsen
Summary: This comprehensive review discusses the major features of irritable bowel syndrome and its interaction with gut microbiota, clinical microbiota-altering treatments such as low FODMAP diet and fecal microbiota transplantation, neuroimaging and microbiota analysis methods, and current and future challenges in big data analysis in IBS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Angela Ancona, Claudia Petito, Irene Iavarone, Valentina Petito, Linda Galasso, Alessia Leonetti, Laura Turchini, Daniela Belella, Daniele Ferrarrese, Giovanni Addolorato, Alessandro Armuzzi, Antonio Gasbarrini, Franco Scaldaferri
Summary: Research highlights the significant bidirectional communication between gut microbiota and the brain in treating central nervous system (CNS) disorders, with a focus on the impact of the first five years of life on the development of gut microbiota, immune system, and psychological alterations. The review specifically explores the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety, and depression, as well as the effects of various therapeutic strategies for mood disorders on gut microbiota.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Cinzia Garofalo, Costanza Maria Cristiani, Sara Ilari, Lucia Carmela Passacatini, Valentina Malafoglia, Giuseppe Viglietto, Jessica Maiuolo, Francesca Oppedisano, Ernesto Palma, Carlo Tomino, William Raffaeli, Vincenzo Mollace, Carolina Muscoli
Summary: Fibromyalgia and Irritable Bowel Syndrome share similar symptoms and may have a common etiology related to alterations in gut microbiota. This review will discuss the similarities between FM and IBS and the potential therapeutic approaches based on microbiota manipulations.
Review
Endocrinology & Metabolism
Sik Yu So, Tor C. Savidge
Summary: Irritable bowel syndrome (IBS) is more common in females, and sex steroids play a critical role in disease onset and symptom severity by regulating visceral sensitivity, gut motility, and psychological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Haomeng Wu, Kai Zhan, Kehan Rao, Huan Zheng, Shumin Qin, Xudong Tang, Shaogang Huang
Summary: The effects of different rat models of diarrhea-predominant irritable bowel syndrome (IBS-D) on the brain-gut-microbiota (BGM) axis were evaluated in this study. The results showed that these models caused changes in brain gut peptides, cytokine levels, spinal cord neuronal activity, intestinal mucosal barrier function, and gut microbiota composition and structure.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Jie Wu, Imke Masuy, Jessica R. Biesiekierski, Heather E. Fitzke, Chinar Parikh, Laurel Schofield, Hafsa Shaikh, Anisha Bhagwanani, Qasim Aziz, Stuart A. Taylor, Jan Tack, Lukas Van Oudenhove
Summary: Fructans induce similar changes in small bowel motility and colon gas and volume in patients with irritable bowel syndrome (IBS) and healthy controls (HCs). Increased symptom responses to fructans in IBS are associated with altered brain responses in pain-related regions, indicating a dysregulation of the gut-brain axis in FODMAP-induced symptom generation in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Integrative & Complementary Medicine
Kiangyada Yaklai, Sintip Pattanakuhar, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: IBS is a chronic dysfunction of the gastrointestinal tract characterized by symptoms such as abdominal pain and discomfort, which significantly affect patients' quality of life. Treatment mainly focuses on symptom management through standard and complementary therapies, including acupuncture. Studies have shown that acupuncture can be effective in treating IBS and research is ongoing to understand its mechanisms of action.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Endocrinology & Metabolism
Minjia Chen, Guangcong Ruan, Lu Chen, Senhong Ying, Guanhu Li, Fenghua Xu, Zhifeng Xiao, Yuting Tian, Linling Lv, Yi Ping, Yi Cheng, Yanling Wei
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with unknown causes, and disruption in the gut-brain axis is believed to be the cause. Recent studies have shown that neurotransmitters play an important role in IBS, affecting blood flow regulation, intestinal motility, immune system, and gut microbiota. These studies have shed light on the mechanisms of neurotransmitters in the pathogenesis of IBS and provided new therapeutic strategies targeting the nervous system or microbiota.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Wu Enqi, Song Jingzhu, Pei Lingpeng, Ling Yaqin
Summary: The study identified significant differences in microbial composition and function between two irritable bowel syndrome rat models, with potential implications for visceral hypersensitivity induced by early adversity. The findings suggest the importance of evaluating gut microbiota characteristics in IBS research and considering potential differences in modeling procedures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Peng-Ning Wu, Shuai Xiong, Peng Zhong, Wan-Qing Yang, Min Chen, Tai-Chun Tang
Summary: This study analyzes the hotspots and trends in the field of irritable bowel syndrome (IBS) and the brain-gut axis using bibliometrics and visual analysis. The results reveal a rapid growth in the number of publications since 2012. The United States, the National University of Ireland, Cork, and J.F. Cryan are the leading contributors in terms of countries, institutions, and authors, respectively. Mechanisms and therapy associated with IBS and the brain-gut axis have been a research focus in recent years, particularly those related to intestinal flora. This is the first bibliometric and visualization analysis of IBS and brain-gut axis-related literature, providing insights into research hotspots and trends.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiwen Ling, Siyuan Peng, Jingbin Zhong, Lirong Guo, Yaqin Xu, Xiaobao Jin, Fujiang Chu
Summary: Chang-Kang-Fang formula (CKF) has therapeutic effects on irritable bowel syndrome (IBS) by modulating the brain-gut axis and regulating gut microbiota. It normalizes dysfunctions of the central and peripheral nervous systems in IBS rats and affects the expressions of BDNF, 5-HT, and related BGP pathway genes. Additionally, CKF induces structural changes in the gut microbiota, leading to alterations in metabolite profiles. Overall, CKF effectively alleviates IBS through bidirectional communication along the microbiota-gut-brain axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Article
Genetics & Heredity
Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Borge Holen, Nadine Parker, Weiqiu Cheng, Linn Rodevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O'Connell, Ole A. Andreassen
Summary: This study characterizes the genetic architecture of irritable bowel syndrome (IBS) and explores its genetic overlap with psychiatric and gastrointestinal phenotypes. It identifies novel genomic risk loci associated with IBS and reveals extensive polygenic overlap with psychiatric and gastrointestinal disorders.
