Article
Chemistry, Multidisciplinary
Soumen Saha, Samagya Banskota, Jianqiao Liu, Nikita Zakharov, Michael Dzuricky, Xinghai Li, Ping Fan, Sonal Deshpande, Ivan Spasojevic, Kedar Sharma, Mario Juan Borgnia, Jeffrey L. Schaal, Ashutosh Raman, Sarah Kim, Jayanta Bhattacharyya, Ashutosh Chilkoti
Summary: Loading Pt(IV) into genetically engineered nanoparticles can enhance the therapeutic efficacy of platinum drugs, potentially yielding more effective platinum-drug nanoformulations.
Review
Biochemistry & Molecular Biology
Pengge Wang, Yunxia Yang, Haoyu Wen, Dongqing Li, Hongmei Zhang, Yanqing Wang
Summary: Natural polysaccharides are excellent biomaterials for nano-drug delivery systems due to their biodegradability and biocompatibility. Platinum drugs, widely used in clinical therapy, face limitations such as toxicity and drug resistance. Recent development of natural polysaccharide-platinum nanomedicines, such as nanomicelles and nanospheres, offer potential solutions to minimize toxicity and optimize drug efficacy through targeted delivery. Future research directions include combining with irradiation and tumor microenvironment for responsive drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Review
Immunology
Yuying Jiang, Chuqiang Yin, Jianning Mo, Xiaoyu Wang, Ting Wang, Guotai Li, Qihui Zhou
Summary: The recent advances in carbon dots (CDs) against diverse oral pathogens and their potential in the treatment of oral microbial infections are discussed in this review. The antimicrobial abilities of CDs against oral planktonic bacteria, intracellular bacteria, oral pathogenic biofilms, and fungi are highlighted. The prospects of CDs in early diagnosis of oral infection and pathogen microbiological examination are also proposed. The current limitations of CDs in the treatment of oral microbial infections are discussed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Youyou Li, Wenbin Lin
Summary: The low success rate of cancer nanomedicines has prompted discussions on the effectiveness of the enhanced permeability and retention (EPR) effect in delivering drugs to tumors. In this review, we discuss alternative strategies for improving nanoparticle delivery to tumors, including transcellular extravasation, receptor-mediated pathways, and protein corona interactions. We summarize recent advancements in platinum-based combination nanomedicines that combine multiple chemotherapeutics and anticancer therapies to enhance drug delivery and antitumor activities. Additionally, we highlight future opportunities and challenges for the translation of these combination nanomedicines into clinical practice.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Haiqin Liao, Chengcheng Niu
Summary: This article introduces the mechanisms by which cancer evades immunological surveillance and the CD47-SIRPα signaling pathway, as well as the applications of nanocarriers developed for this signaling pathway in anticancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Morgane Renault-Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul, Karine Andrieux
Summary: Flavonoids are promising molecules for cancer treatment due to their various properties, but vectorization is necessary due to their lipophilic properties and chemical instability. Co-encapsulation with other anti-cancer agents can achieve synergistic effects, delay drug resistance, or reduce toxicity. However, co-encapsulation may affect the properties and stability of nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biophysics
Pengyu Zhu, Muhammad Rizwan Younis, Guiqi Ma, Qianting Zhang, Ruibing An, Kaiqi Wang, Jian Dong
Summary: Dendritic polymer-platinum conjugates (G5-PEG-Pt) were designed as pH-responsive nanovesicles for target delivery of platinum drugs. The G5-PEG-Pt exhibited a well-defined structure, intrinsic fluorescence, and acid-responsive drug release. They were able to enter cancer cells and achieve comparable cytotoxicity to free cisplatin. Furthermore, the nanovesicles showed enhanced tumor platinum uptake compared to free cisplatin, potentially improving the therapeutic efficacy of platinum drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Medicine, Research & Experimental
Chunyu Zhang, Chao Xu, Xueyun Gao, Qingqiang Yao
Summary: This article discusses the application and development of platinum-based drugs in cancer treatment, particularly the targeted modification of platinum nanoclusters. The new platinum drugs provide a promising prospect for improving anti-cancer treatments.
Article
Engineering, Biomedical
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
Summary: Graphene-based 2D nanomaterials have unique physicochemical characteristics that can be used in various biomedical applications, such as drug delivery and treatment. This study investigates the distribution of thin graphene oxide (GO) nanosheets in GBM mouse models and designs a novel nano-chemotherapeutic approach using GO sheets as platforms for drug complexation. The results demonstrate enhanced cytotoxic effects of the GO-BTZ complex in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Damir Vukoja, Josipa Vlainic, Vanja Ljolic Bilic, Lela Martinaga, Iva Rezic, Diana Brlek Gorski, Ivan Kosalec
Summary: The growing number of drug-resistant infections is a major global health issue, and finding new approaches to combat antimicrobial resistance is essential. This study found that commercially purchased colloidal platinum nanoparticles have strong antibacterial effects against both standard laboratory and drug-resistant strains of E. coli and K. pneumoniae. The mechanisms of action for these antibacterial effects involve damage to bacterial cell walls and the induction of reactive oxygen species. Further research is needed to fully understand these mechanisms.
Article
Chemistry, Multidisciplinary
Claudia Martins, Catarina Pacheco, Catarina Moreira-Barbosa, Angela Marques-Magalhaes, Sofia Dias, Marco Araujo, Maria J. Oliveira, Bruno Sarmento
Summary: This study generated human GBM heterotypic multicellular tumor microtissues (MCTMs) using high-throughput 3D modeling, which mimicked the spatial organization and biological features of GBM. The bioactivity of tumor-targeted nanoparticles and anti-cancer drugs were evaluated in the MCTMs, and it was found that the targeted nanoparticles exhibited higher cell uptake and anti-proliferative effect.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Engineering, Environmental
Showkat Ali Ganie, Luqman Jameel Rather, Qing Li
Summary: Polysaccharides are natural polymers formed by microorganisms, animals, and plants, playing an important role in the development of living organisms. Curdlan, a natural polymer with exceptional pharmacological characteristics, has the ability to form structures with bioactive molecules for anticancer and antimicrobial applications. It has been explored as a potential biomaterial for delivering drugs with bioactive molecules into biomacromolecules of desired functions.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Priya Mondal, Syed Musthapa Meeran
Summary: Platinum-based drugs are widely used for cancer therapy, but long-term use can lead to chemoresistance and side effects. Recent research has shown that targeting non-coding RNAs (ncRNAs) could be an effective approach for overcoming chemoresistance in lung cancer. This review article discusses the role of ncRNA in chemoresistance and its molecular mechanisms in human lung cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Nisar Ahmad, Jan Muhammad, Khalil Khan, Wajid Ali, Hina Fazal, Mohammad Ali, Latif-Ur Rahman, Hayat Khan, Muhammad Nazir Uddin, Bilal Haider Abbasi, Christophe Hano
Summary: Prunella vulgaris is a medicinally important plant that can be used for the development of antimicrobial drugs. This study found that calli cultures of Prunella vulgaris exposed to gold and silver nanoparticles exhibited inhibitory effects against certain microbes.
Article
Biochemistry & Molecular Biology
Bisma Meer, Anisa Andleeb, Junaid Iqbal, Hajra Ashraf, Kushif Meer, Joham Sarfraz Ali, Samantha Drouet, Sumaira Anjum, Azra Mehmood, Taimoor Khan, Mohammad Ali, Christophe Hano, Bilal Haider Abbasi
Summary: This study successfully synthesized zinc oxide nanoparticles using the seed extract of Lepidium sativum through bio-assisted synthesis. The synthesized nanoparticles were characterized using various spectroscopy and imaging techniques and were tested for various in vitro biological assays. The results showed that the bio-assisted zinc oxide nanoparticles exhibited excellent antioxidant, antibacterial, and potential in cancer therapeutics.
Article
Chemistry, Physical
Muhammad Ovais, Arbab Ali, Sana Ullah, Ali Talha Khalil, Atia Atiq, Maria Atiq, Nurcan Dogan, Zabta Khan Shinwari, Manzar Abbas
Summary: Increased antibiotic resistance is a major healthcare challenge, and short peptide-modulated metal nanomaterials offer a promising solution with their biocompatibility and reduced toxic effects. These composite nanoparticles have shown potential in fighting bacterial infections and wound disinfection.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Mariam Hashim, Huma Mujahid, Samina Hassan, Shanila Bukhari, Iram Anjum, Christophe Hano, Bilal Haider Abbasi, Sumaira Anjum
Summary: Liver and kidney diseases are common worldwide, and the use of nanoparticles has shown potential for safe delivery of medications with minimal side effects. Nanoparticles have anti-inflammatory and antioxidant effects, and can also induce apoptosis in malignant liver and kidney cells.
Review
Pharmacology & Pharmacy
Haiyan Huang, Arbab Ali, Yi Liu, Hui Xie, Sana Ullah, Shubham Roy, Zhiyong Song, Bing Guo, Jian Xu
Summary: This review provides an overview of advanced image-guided approaches for bacterial diagnosis and therapies, focusing on the design and fabrication of photo-responsive materials for improved bacterial theranostics. The review highlights current challenges and future perspectives for the clinical translation of image-guided systems in bacterial infection therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Naeem Bajwa, Mehnaz Khanum, Gouhar Zaman, Muhammad Asad Ullah, Umar Farooq, Muhammad Waqas, Nisar Ahmad, Christophe Hano, Bilal Haider Abbasi
Summary: White light exposure has a significant impact on enhancing the production of bioactive compounds, antioxidant activity, and biomass in M. oleifera callus culture. Continuous white light (24 h) resulted in the highest biomass production, total phenolic content, flavonoid content, and antioxidant activity. White light exposure also enhanced the biosynthesis of secondary metabolites.
Article
Biotechnology & Applied Microbiology
Muhammad Zia, Joham Sarfraz Ali, Saad Hanif, Anila Sajjad, Bilal Haider Abbasi
Summary: This study is the first to report on the efficacy of lupeol as a salt stress mitigating molecule in plants. It found that lupeol can alleviate the adverse effects of salt stress on plant growth and biomass traits. However, when lupeol was applied along with salt stress, the activity of antioxidative enzymes and the concentrations of phenolics and flavonoids decreased.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Review
Biochemistry & Molecular Biology
Hasnat Tariq, Saaim Asif, Anisa Andleeb, Christophe Hano, Bilal Haider Abbasi
Summary: Flavonoids, a heterogeneous family of plant polyphenolic compounds, have significant bioactivity in anti-cancer, antioxidant, anti-inflammatory, and anti-microbial activities. However, traditional approaches for their production have limitations. Genetic engineering tools offer promise for exploring and scaling up production of flavonoids by modifying biosynthetic pathways in plants and microbes.
Article
Food Science & Technology
Saurabh Bhatia, Ahmed Al-Harrasi, Sana Ullah, Mohammed Said Al-Azri, Alaa El-Din Ahmed Bekhit, Layal Karam, Mohammed Albratty, Mohammed F. F. Aldawsari, Md. Khalid Anwer
Summary: Ginger essential oil (GEO) loaded chitosan (CS) based films incorporated with varying concentrations of gelatin (GE) were fabricated and dried at different conditions. Films dried at 45 degrees C showed better physical attributes, more transparency, and better mechanical characteristics compared to films dried at 25 degrees C. The antioxidant activity was higher in films dried at low temperature, while an increase in gelatin concentration improved tensile strength and swelling factor.
Article
Infectious Diseases
Sidra Rahman, Sana Ullah, Zabta Khan Shinwari, Muhammad Ali
Summary: Bats serve as reservoirs for highly contagious and pathogenic viral families. Recent spillover events of viral species from bats, such as SARS-CoV, MERS-CoV and SARS-CoV2, have caused severe outbreaks. Detecting and studying these viral species in bats is crucial for early pandemic potential identification.
INFECTION GENETICS AND EVOLUTION
(2023)
Article
Plant Sciences
Urooj Ali, Muhammad Mustajab Khan, Naveera Khan, Rida tul Haya, Muhammad Usama Asghar, Bilal Haider Abbasi
Summary: This literature review focuses on the significance and applications of secondary metabolites extracted from Chimaphila umbellata, as well as biotechnological approaches to improve its utilization. The plant is home to many industrially and medicinally important phytochemicals, primarily phenolics, sterols, and triterpenoids. The review also discusses the challenges of working with C. umbellata, including its conservation status, in-vitro cultivation issues, and research and development concerns.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Plant Sciences
Muhammad Asad Ullah, Faiza Zareen Gul, Gouhar Zaman, Junaid Iqbal, Samantha Drouet, Duangjai Tungmunnithum, Christophe Hano, Bilal Haider Abbasi
Summary: In vitro shoot culture was used to induce rapid micro-propagation of Ajuga integrifolia, resulting in disease-free plantlets and high yield agitated micro-shoot cultures. The addition of Chitosan and Melatonin in a dose-dependent manner enhanced the accumulation of secondary metabolites and biomass in the micro-shoots.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Review
Oncology
Areej Shahbaz, Tehreem Mahmood, Muhammad Uzair Javed, Bilal Haider Abbasi
Summary: Microbes, with their immense metabolic capability, have complex relationships with cancer and can be used as tumor-specific infectious microorganisms in cancer therapy. However, the toxicity of traditional cancer treatments and the rise of drug resistance in tumor cells pose challenges. Alternative strategies that target tumor cells more effectively and selectively are needed. Cancer immunotherapy has greatly advanced the fight against cancer by utilizing tumor-invading immune cells and immune responses. Bacterial and viral cancer therapeutics, as promising immunotherapies, are being developed to overcome the hurdles in cancer treatment.
Article
Chemistry, Multidisciplinary
Hajra Ashraf, Bisma Meer, Junaid Iqbal, Joham Sarfraz Ali, Anisa Andleeb, Hira Butt, Muhammad Zia, Azra Mehmood, Muhammad Nadeem, Samantha Drouet, Jean-Philippe Blondeau, Nathalie Giglioli-Guivarc'h, Chunzhao Liu, Christophe Hano, Bilal Haider Abbasi
Summary: The goal of this study was to fabricate ZnO nanoparticles using chemical and biological routes and evaluate their physiochemical behavior and biological potentials. The synthesized nanoparticles were confirmed using spectroscopy and imaging techniques. The nanoparticles showed high antioxidant, enzyme inhibition, antibacterial, and cytotoxicity potential. The green-mediated nanoparticles exhibited superior biological potential compared to the chemically derived nanoparticles. The results suggested that these nanoparticles have promising applications in antimicrobial and cancer therapeutics.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sadaf Mushtaq, Khuram Shahzad, Muhammad Rizwan, Anwar Ul-Hamid, Bilal Haider Abbasi, Waqas Khalid, Muhammad Atif, Nafees Ahmad, Zulqurnain Ali, Rashda Abbasi
Summary: In this study, the synthesis of magneto-electric core-shell nanorods was reported for targeted drug delivery. The results showed that the nanorods achieved up to 98% drug release under an external magnetic field, and exhibited strong magnetic field and dose dependent cytotoxic response in cells and 3D models. Additionally, the nanorods demonstrated the ability to inhibit the activity of multidrug resistance pumps, indicating effectiveness in chemo-resistant cancers. These findings suggest the potential importance of magneto-electric core-shell nanorods in cancer nanotherapeutics.