Article
Multidisciplinary Sciences
Katarzyna Juzon, Marzena Warchol, Kinga Dziurka, Ilona Mieczyslawa Czyczylo-Mysza, Izabela Marcinska, Edyta Skrzypek
Summary: This study investigated the influence of 2,4-dichlorophenoxyacetic acid (2,4-D) concentration on doubled haploid (DH) production. It was found that a higher concentration of 2,4-D can enhance the formation of haploid plants and seeds, but strong genotypic variation may limit the development of effective breeding methods.
Article
Plant Sciences
Xue Feng, Quan Meng, Jianbin Zeng, Qian Yu, Dengan Xu, Xuehuan Dai, Lei Ge, Wujun Ma, Wenxing Liu
Summary: In this study, a total of 60 SnRK genes were discovered in maize and classified into three subfamilies. Gene structure analysis showed that the ZmSnRK gene family had undergone purifying selection. The expression profiles of ZmSnRKs exhibited significant differences in various tissues and abiotic stresses. Additionally, ZmPP2Cs that interact with ZmSnRK proteins and miRNAs that target ZmSnRKs were identified.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Abil Dermail, Thomas Lubberstedt, Willy Bayuardi Suwarno, Sompong Chankaew, Kamol Lertrat, Vinitchan Ruanjaichon, Khundej Suriharn
Summary: This study aimed to evaluate the combining ability, line per se performance, and hybrid performance of three genetic pools in terms of haploid induction rate (HIR), R1-nj seed set, and agronomic traits. The results showed that the temperate inducer BHI306 was the best general combiner for HIR and R1-nj seed set.
FRONTIERS IN PLANT SCIENCE
(2023)
Letter
Plant Sciences
Lu Long, Ya-Mei Feng, Shen-Zhai Shang, Jing-Ruo Zhao, Gai-Yuan Hu, Fu-Chun Xu, Chun-Peng Song, Shuang-Xia Jin, Wei Gao
Summary: This article describes the generation of a cotton ghdmp mutant using the CRISPR system, which exhibits a high haploid induction rate in the progeny.
Article
Plant Sciences
Mikhail A. Filyushin, Elena Z. Kochieva, Anna Shchennikova
Summary: In this study, a new DREB gene, ZmDREB2.9, was identified and characterized in maize. It was found to have two splice isoforms and showed differential expression in various tissues. Comparison with other genes revealed that ZmDREB2.9-S, ZmDREB2.2, and ZmDREB2.1/2A may play important roles in maize stress resistance.
Article
Biochemistry & Molecular Biology
Lu Lu, Quancan Hou, Linlin Wang, Tianye Zhang, Wei Zhao, Tingwei Yan, Lina Zhao, Jinping Li, Xiangyuan Wan
Summary: This study identified 55 PG family genes from the maize genome, revealing their evolutionary relationship and expression patterns. ZmPGs were grouped into six Clades, with highly conserved gene structures suggesting potential conservation of function. 18 ZmPGs were highly expressed in maize anther, showing possible functional divergence among ZmPGs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ewa W. Piskorz, Linhao Xu, Yingrui Ma, Hua Jiang
Summary: Our study found that haploid induction and genome doubling in Arabidopsis can result in differential DNA methylation, offering a novel approach to induce epialleles.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Henrique Uliana Trentin, Recep Yavuz, Abil Dermail, Ursula Karoline Frei, Somak Dutta, Thomas Lubberstedt
Summary: The effectiveness of haploid induction systems depends on high haploid induction rate (HIR) and resource savings. An isolation field approach for hybrid induction is proposed. The success of efficient haploid production relies on inducer traits such as high HIR, abundant pollen production, and tall plants. Evaluation of seven hybrid inducers and their respective parents showed that mid-parent heterosis benefited plant height, ear height, and tassel size. Two promising hybrid inducers, BH201/LH82-Ped126 and BH201/LH82-Ped128, were identified for haploid induction in isolation fields. Hybrid inducers offer convenience and resource-effectiveness by improving plant vigor without compromising HIR.
Article
Agronomy
Fucheng Zhao, Nan Wang, Fei Bao, Guangwu Zhao, Liquan Jing, Guiyue Wang, Qinghui Han, Zhuanfang Hao, Bin Chen
Summary: Clarifying the genetic basis of trace element accumulation is crucial for breeding new maize varieties with high quality. This study conducted a genome-wide association study on the accumulation of iron, manganese, copper, zinc, cadmium, and arsenic in maize kernels, identifying several genes and SNPs associated with different trace elements. The findings provide insights into the molecular mechanism of trace element accumulation and offer candidate genes for breeding high nutritional quality maize varieties.
Article
Agronomy
Jiaojiao Ren, Xiaoyu Zhang, Zongze Li, Penghao Wu
Summary: This study used an F-2 population derived from inbred maize lines to dissect the genetic basis of maternal haploid inducibility (MHI) through QTL analysis and QTL by environment interaction analysis. Ten QTLs for MHI were identified, with three candidate genes involved in seed development. The study provides valuable information for understanding the genetic basis of MHI in maize breeding.
Article
Biotechnology & Applied Microbiology
Yunying Cao, Tingyu Shan, Hui Fang, Kangtai Sun, Wen Shi, Bei Tang, Junping Wu, Kai Wang, Ping Li, Baohua Wang
Summary: In this study, we identified 59 SOS3 genes in the maize B73 genome and found a close relationship between phylogenetic classification and gene structure. Gene duplication was found to play an important role in the expansion of the SOS3 gene family. The expression analysis and subcellular localization results demonstrated differential gene expression and localization during salt treatment.
Article
Plant Sciences
Alejandro Ledesma, Fernando Augusto Sales Ribeiro, Alison Uberti, Jode Edwards, Sarah Hearne, Ursula Frei, Thomas Lubberstedt
Summary: The molecular characterization analysis confirmed the loss of genetic variability from C0 to C17 through the recurrent selection process in maize breeding.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Plant Sciences
Ivan Maryn Marin-Montes, Juan Enrique Rodriguez-Perez, Alejandrina Robledo-Paz, Eulogio de la Cruz-torres, Aureliano Pena-Lomeli, Jaime Sahagun-Castellanos
Summary: This review evaluates the potential of gynogenesis as a breeding method for tomatoes. By presenting successful cases of gynogenesis, the authors suggest that these methods can be used to obtain doubled haploids in tomato breeding programs.
Review
Plant Sciences
Ruwani Mayakaduwa, Tara Silva
Summary: Haploid plants are of great interest to crop breeders due to their ability to accelerate breeding. In vitro and in vivo methods are being explored to improve the success rate of haploid induction in indica rice and other cereals. In particular, in vivo methods that utilize mutants are promising and do not require tissue culture. These methods, combined with gene editing technologies, offer a pragmatic approach to improving indica rice cultivars.
Article
Biotechnology & Applied Microbiology
Xuehang Xiong, Jianxin Li, Pingping Su, Haiyang Duan, Li Sun, Shuhao Xu, Yan Sun, Haidong Zhao, Xiaoyang Chen, Dong Ding, Xuehai Zhang, Jihua Tang
Summary: Through comparative analysis of GWAS models, this study identified 140 quantitative trait nucleotides (QTNs) associated with maize chlorophyll content, involving 481 genes and explaining 0.29-10.28% of phenotypic variation. The GRMZM2G110408 (ZmCCS3) gene was identified by multiple models and in multiple environments, and its encoded protein likely contributes to chlorophyll biosynthesis. These findings are important for ideotype-based breeding of new maize varieties with high photosynthetic efficiency.
Review
Clinical Neurology
Michelle H. S. Tosin, Beatriz Guitton R. B. de Oliveira, Christopher G. Goetz, Donald Morisky, Victor McConvey, Matej Skorvanek, Anette Schrag, Pablo Martinez-Martin, Glenn T. Stebbins
Summary: This study critically reviewed the measurement properties of rating scales used to assess medication adherence in Parkinson's disease (PD) and made recommendations. Several scales were suggested for use, but further work is needed to resolve the issues or develop a new scale that meets all criteria.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Anette Schrag, Jens Bohlken, Lotte Dammertz, Stefan Teipel, Wiebke Hermann, Manas K. Akmatov, Jorg Batzing, Jakob Holstiege
Summary: The prodromal phase of Parkinson disease (PD) can last for more than 10 years. This study aimed to identify the association between subsequent PD diagnosis and a range of risk factors and prodromal features, including lifestyle factors, comorbidities, and potential extracerebral manifestations of PD. The findings suggest that the associations between PD and certain risk factors, comorbidities, and prodromal symptoms may reflect early extrastriatal and extracerebral pathology of PD.
Article
Clinical Neurology
Joy Read, Sarah Cable, Gergely Bartl, Charlotte Loefqvist, Susanne Iwarsson, Anette Schrag
Summary: This study aims to understand the experiences and satisfaction of family caregivers in providing care for late-stage Parkinson's patients. The findings revealed the need for continuous support, unmet service provision needs, and the burden of coordinating various aspects of care. Family caregivers also reported assuming new roles and experiencing multiple losses, but they were able to mitigate some of the challenges through support from professionals and organized and informal support.
PARKINSONS DISEASE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Hanyuying Wang, Yibo Zhao, Anette Schrag
Summary: This study aimed to identify the clinical factors and biomarkers associated with the development of anxiety in newly diagnosed Parkinson's disease (PD) patients, as well as to predict the risk factors for increasing anxiety levels over time. The results showed that anxiety development is related to non-dopaminergic or extrastriatal pathology rather than a dopaminergic deficit in the basal ganglia. Early dysexecutive function predicts the development of anxiety, and an increase in anxiety levels correlates most strongly with global cognitive decline.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Rowena K. Merritt, Sarah Hotham, Anette Schrag
Summary: This study investigated the support needs of carers of People with Parkinson's (PwP) in 11 European countries. Results showed that carers often felt the need to help patients get a diagnosis and deal with the impact of the diagnosis on the family. Information on medication was particularly important for carers, and many felt their informational needs differed from that of the patients. Many carers also felt the need to be present at all appointments to request referrals or ask for medication changes. Carers of patients in later stages of the disease often reported feeling isolated and having no time for themselves.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Clinical Neurology
Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P. Roiser
Summary: This study found that dopaminergic dysfunction in the midbrain is associated with motivational symptoms such as apathy and anhedonia in Parkinson's disease (PD), and this association becomes evident as the disease progresses. These findings can inform intervention strategies for improving the treatment of PD patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Cristina Simonet, Philipp Mahlknecht, Kathrin Marini, Klaus Seppi, Aneet Gill, Jonathan P. Bestwick, Andrew J. Lees, Gavin Giovannoni, Anette Schrag, Alastair J. Noyce
Summary: The PREDICT-PD study utilized a risk algorithm to stratify individuals for future Parkinson's disease and found an association between risk scores and sub-threshold parkinsonism. The algorithm was able to identify individuals with motor decline over time.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Laura Perez-Carbonell, Cristina Simonet, Harneek Chohan, Aneet Gill, Guy Leschziner, Anette Schrag, Alastair J. Noyce
Summary: This study investigated the experiences and views of risk disclosure in patients with isolated rapid eye movement sleep behavior disorder (iRBD). One-third of the patients reported they were not informed about the link between iRBD and other conditions at diagnosis. Most patients wanted to receive information about the potential implications of iRBD when the diagnosis was made.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Davide Martino, Vikram Karnik, Roongroj A. Bhidayasiri, Deborah A. A. Hall, Robert A. Hauser, Antonella M. Macerollo, Tamara M. Pringsheim, Daniel A. Truong, Stewart A. Factor, Matej Skorvanek, Anette Schrag, IPMDS Rating Scales Review Comm
Summary: An International Parkinson and Movement Disorder Society subcommittee aimed to rate the psychometric quality of severity and screening instruments for antipsychotic-associated movement disorders. They identified 23 instruments, of which 7 severity rating instruments and 3 screening instruments were recommended with caveats due to insufficient psychometric properties and long duration of administration. New psychometric studies and revision of existing instruments are recommended to address these caveats and improve the clarity of their nomenclature.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Karel Kostev, Corinna Doege, Louis Jacob, Lee Smith, Ai Koyanagi, Celina Gollop, Anette Schrag
Summary: This study analyzed whether prescriptions of antiepileptic drugs (AEDs) are significantly associated with an increased incidence of Parkinson's disease (PD) in the German population. The results showed that diagnoses of epilepsy, restless legs syndrome, and neuropathy, as well as the prescription of AEDs including sodium valproate, gabapentin, and pregabalin, were significantly associated with an increased incidence of PD. Further studies are needed to confirm the present results.
Article
Plant Sciences
Luis Antonio Lopez, John Ochieng, Mario Pacheco, Leocadio Martinez, Hamilton Amoshe Omar, Manje Gowda, Boddupalli M. Prasanna, Kanwarpal S. Dhugga, Vijay Chaikam
Summary: Doubled haploid (DH) technology is crucial for maize breeding programs, as it expedites inbred line development and improves breeding efficiency. Unlike other plant species, maize DH production uses a simple and efficient in vivo haploid induction method. However, it requires two complete crop cycles for DH line generation, which can be time-consuming.
Article
Neurosciences
Emma. K. Blundell, Laura. E. Grover, Joshua Stott, Anette Schrag
Summary: Anxiety is a common and important non-motor symptom of Parkinson's disease (PD), yet it is poorly understood, underdiagnosed, and undertreated. This study aimed to explore the experience of anxiety for people with Parkinson's (PWP) through interviews and thematic analysis. The findings revealed the complexity of anxiety, its impact on daily life, and the connection to PD. The study highlights the need for better recognition and treatment of anxiety in PWP.
NPJ PARKINSONS DISEASE
(2023)
Article
Agronomy
Albrecht E. E. Melchinger, Rohan Fernando, Christian Stricker, Chris-Carolin Schoen, Hans-Juergen Auinger
Summary: Genomic prediction in hybrid breeding depends on the composition of the training set. This study investigates the prediction accuracy of GCA for different types of parents and hybrids, determined by the number of parents and crosses per parent. The results show that for GCA of I0 parents and H0 hybrids, c = 1 yields the highest accuracy, while for GCA of I1 parents and H1, H2 hybrids, c = 1 yields the lowest accuracy.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Agronomy
Albrecht E. Melchinger, Matthias Frisch
Summary: Using full-sib families for model training instead of half-sib families leads to higher short- and long-term selection gain in reciprocal recurrent genomic selection for hybrid breeding.
THEORETICAL AND APPLIED GENETICS
(2023)