Article
Multidisciplinary Sciences
Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Caroline Conceicao Guarda, Rodrigo Mota Oliveira, Luciana Magalhaes Fiuza, Setondji Cocou Modeste Alexandre Yahouedehou, Suellen Pinheiro Carvalho, Joelma Santana dos Santos Neres, Antonio Mateus de Jesus Oliveira, Cleverson Alves Fonseca, Valma Maria Lopes Nascimento, Isa Menezes Lyra, Milena Magalhaes Aleluia, Marilda Souza Goncalves
Summary: Priapism, a urologic emergency often associated with sickle cell disease, was found to be linked with alterations in laboratory biomarkers and lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to have a lower risk of priapism. Multivariate analysis showed that low HbF and NOm were independently associated with priapism.
Article
Pharmacology & Pharmacy
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao, Peiqing Liu
Summary: This study found that SIRT6 regulates endothelial function by modulating the activity of NOS3. SIRT6 activates NOS3 through deacetylation and facilitates its interaction with calmodulin, leading to increased nitric oxide generation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Tamara Sljivancanin Jakovljevic, Olivera Kontic-Vucinic, Nadja Nikolic, Jelena Carkic, Jelena Stamenkovic, Ivan Soldatovic, Jelena Milasin
Summary: -786 T/C and VNTR 4b/a eNOS gene polymorphisms are associated with the risk of preeclampsia in Serbian patients. Homozygotes for VNTR polymorphism have a higher risk of developing preeclampsia.
REPRODUCTIVE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qing-Fan Lin, Jing-Hong Rao, Shi-Mu Luo, Qing-Mu Wang, Li-Feng Deng, Xuan Chen, Chang-Di Chen, You-Fang Chen
Summary: This study found that gene polymorphisms of eNOS were associated with the development of PAH in newborns with CHD in South Fujian. Specifically, the GT/TT genotype of eNOS rs1799983 was associated with a higher risk of PAH, and this may be due to decreased nitric oxide production.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Biotechnology & Applied Microbiology
Mustafa Ozkan, Nurullah Gunay, Elif Funda Sener, Ozgur Karcioglu, Reyhan Tahtasakal, Fatma Dal, Nahide Ekici Gunay, Abdullah Tuncay Demiryurek
Summary: The study revealed significant associations between TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms with susceptibility to sepsis in the Turkish population. No significant associations were found with other polymorphisms studied in this research.
JOURNAL OF GENE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer C. Hill, Marie Billaud, Tara D. Richards, Mary P. Kotlarczyk, Sruti Shiva, Julie A. Phillippi, Thomas G. Gleason
Summary: This study found differential expression of Nos3 related to valve morphology and aneurysm, providing new insights into the pathophysiology of aneurysms and supporting the idea that mechanisms of ascending aortopathy in BAV and TAV patients are distinct.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wen-Fang He, Rong Qin, Yu-Hai Gao, Jian Zhou, Juan-Juan Wei, Jing Liu, Xue-Feng Hou, Hui-Ping Ma, Cory J. Xian, Xue-Yan Li, Ke-Ming Chen
Summary: This study found that pulsed electromagnetic fields (PEMFs) can promote osteoblastic differentiation by activating the NOS/NO/sGC/cGMP/PKG signaling pathway, which requires the presence of primary cilia. The study also observed the activation of the NO/cGMP signaling pathway in the ciliary compartment and showed that PEMFs cannot stimulate osteoblastic differentiation if the NO signaling pathway is blocked or ciliogenesis is inhibited.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Multidisciplinary Sciences
Giorgia Marisi, Irene Azzali, Alessandro Passardi, Francesca Rebuzzi, Giulia Bartolini, Milena Urbini, Matteo Canale, Chiara Molinari, Laura Matteucci, Francesco Giulio Sullo, Silvia Angela Debonis, Chiara Gallio, Graziana Gallo, Giovanni Luca Frassineti, Paola Ulivi
Summary: This study aimed to validate the predictive impact of eNOS and VEGF polymorphisms on the response to Bev plus chemotherapy in mCRC patients. The results showed that these polymorphisms were not associated with PFS, OS, and ORR. Haplotype analysis also did not confirm the previous findings. Therefore, these polymorphisms failed to serve as predictive factors for treatment response in mCRC patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ruichao Li, Ansu Zhao, Xiaoyan Diao, Juhui Song, Chanjuan Wang, Yanhong Li, Xiaolan Qi, Zhizhong Guan, Ting Zhang, Yan He
Summary: This study found that the single nucleotide polymorphisms rs1808593 and rs7830 of the NOS3 gene are associated with essential hypertension in the Han, Miao, and Buyi populations in Guizhou, China.
Article
Clinical Neurology
Ibrahim Sahin, Hanife Saat
Summary: This study identified 22 specific HSPs-HSAs-SAP mutations, including 14 novel mutations, in 25 patients with spastic or spastic-ataxic gait, expanding the clinical and molecular scope of HSP and clarifying the concept of the spasticity-ataxia phenotype. The research reveals a robust genotype-phenotype heterogeneity in the disease, broadening the spectrum of HSPs and HSAs related gene mutations and providing insights for genotype-phenotype correlations for HSPs and HSAs.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Genetics & Heredity
Pelin Ercoskun, Cigdem Yuce Kahraman, Kubra Adanur Saglam, Momen Kanjee, Abdulgani Tatar
Summary: Turnpenny-Fry syndrome is a rare genetic disorder characterized by intellectual disability, developmental delay, facial dysmorphism, and skeletal abnormalities. Mutations of the PCGF2 gene are responsible for this syndrome, with only 13 reported cases to date.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Genetics & Heredity
Cigdem Yuce Kahraman, Pelin Ercoskun, Omer Yakar, Abdulgani Tatar
CLINICAL DYSMORPHOLOGY
(2022)
Article
Genetics & Heredity
Munis Dundar, Umut Fahrioglu, Saliha Handan Yildiz, Burcu Bakir-Gungor, Sehime Gulsun Temel, Haluk Akin, Sevilhan Artan, Tulin Cora, Feride Iffet Sahin, Ahmet Dursun, Ozlem Sezer, Hakan Gurkan, Murat Erdogan, C. Nur Semerci Gunduz, Atil Bisgin, Ozturk Ozdemir, Ayfer Ulgenalp, E. Ferda Percin, Malik Ejder Yildirim, Selahaddin Tekes, Haydar Bagis, Huseyin Yuce, Nilgun Duman, Gokay Bozkurt, Kanay Yararbas, Mahmut Selman Yildirim, Ahmet Arman, Ercan Mihci, Serpil Eraslan, Zuhal Mert Altintas, Huri Sema Aymelek, Hatice Ilgin Ruhi, Abdulgani Tatar, Mahmut Cerkez Ergoren, G. Ozan Cetin, Umut Altunoglu, Ahmet Okay Caglayan, Berrin Yuksel, Yusuf Ozkul, Cetin Saatci, Sercan Kenanoglu, Nilgun Karasu, Bilge Dundar, Firat Ozcelik, Mikail Demir, Betul Seyhan Siniksaran, Hande Kulak, Kubra Kiranatlioglu, Kubra Baysal, Ulviyya Kazimli, Hilal Akalin, Ayca Dundar, Mehmet Boz, Arslan Bayram, Asli Subasioglu, Fatma Kurt Colak, Neslihan Karaduman, Meltem Cerrah Gunes, Nefise Kandemir, Busra Aynekin, Rabia Emekli, Izem Olcay Sahin, Sevda Yesim Ozdemir, Muge Gulcihan Onal, Abdurrahman Soner Senel, Muammer Hakan Poyrazoglu, Ayse Nur Pac Kisaarslan, Sebnem Gursoy, Mevlut Baskol, Mustafa Calis, Huseyin Demir, Gozde Erturk Zararsiz, Mujgan Ozdemir Erdogan, Muhsin Elmas, Mustafa Solak, Memnune Sena Ulu, Adam Thahir, Zafer Aydin, Umut Atasever, Sebnem Ozemri Sag, Lamiya Aliyeva, Adem Alemdar, Berkcan Dogan, Cemre Ornek Erguzeloglu, Niyazi Kaya, Ferda Ozkinay, Ozgur Cogulu, Asude Durmaz, Huseyin Onay, Emin Karaca, Burak Durmaz, Ayca Aykut, Oguz Cilingir, Beyhan Durak Aras, Ebru Erzurumluoglu Gokalp, Serap Arslan, Arda Temena, Konul Haziyeva, Sinem Kocagil, Hasan Bas, Ezgi Susam, Ali Riza Keklikci, Elif Sarac, Nadir Kocak, Suleyman Nergiz, Yunus Kasim Terzi, Selin Akad Dincer, Esra Sidika Baskin, Gunes Cakmak Genc, Oguzhan Bahadir, Aslihan Sanri, Serbulent Yigit, Hilmi Tozkir, Sinem Yalcintepe, Nese Ozkayin, Aslihan Kiraz, Burhan Balta, Gizem Akinci Gonen, E. Emre Kurt, Gulay Gulec Ceylan, Ahmet Cevdet Ceylan, Sukran Erten, Sevcan Tug Bozdogan, Ibrahim Boga, Mustafa Yilmaz, Fatma Silan, Mehmet Kocabey, Altug Koc, Tufan Cankaya, Elcin Bora, Ozlem Giray Bozkaya, Derya Ercal, Mehmet Ali Ergun, Sezen Guntekin Ergun, Yesim Sidar Duman, Serife Busra Beyazit, Veysiye Hulya Uzel, Serda Em, Muhammer Ozgur Cevik, Recep Eroz, Mercan Demirtas, Cem Koray Firat, Zehra Manav Kabayegit, Mustafa Altan, Lamiya Mardan, Ceyhan Sayar, Sait Tumer, Burcu Turkgenc, Hilal Keskin Karakoyun, Betul Tunc, Seda Kuru, Aysegul Zamani, Bilgen Bilge Geckinli, Esra Arslan Ates, Ozden Altiok Clark, Asli Toylu, Mert Coskun, Banu Nur, Ilmay Bilge, Oya Uygur Bayramicli, Hakan Emmungil, Zeynep Komesli, Mujdat Zeybel, Figen Gurakan, Mehmet Tasdemir, Rejin Kebudi, Halil Gurhan Karabulut, Timur Tuncali, Nuket Yurur Kutlay, Cigdem Yuce Kahraman, Nerin Bahceciler Onder, Ilke Beyitler, Salih Kavukcu, Pinar Tulay, Ozgur Tosun, Gulten Tuncel, Gamze Mocan, Hamdi Kale, Zehra Oya Uyguner, Aynur Acar, Mert Altinay, Levent Erdem
Summary: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder characterized by recurrent fever, abdominal pain, joint manifestations, erysipelas-like erythema, and renal complications. This study analyzes the MEFV gene analysis results and clinical findings of 27,504 patients from Turkey and Northern Cyprus to better understand the genotype-phenotype correlation and provide insights into this complex disease.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Ibrahim Sahin, Hanife Saat
Summary: This study identified mutated genes associated with hereditary cancers and suggested that monoallelic mutations in MUTYH, MSH6, APC, CDH1, MHS2, and PMS2 may also contribute to hereditary breast-ovarian cancer. Assessing and researching new variants of known cancer candidate genes will play an important role in improving individual risk prediction, therapy, and prognosis for familial cancers.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Review
Pharmacology & Pharmacy
Hasan Turkez, Mehmet Enes Arslan, Joice Nascimento Barboza, Cigdem Yuce Kahraman, Damiao Pergentino de Sousa, Adil Mardinoglu
Summary: Alzheimer's Disease is a major neurodegenerative disease with no definitive treatment. However, ferulic acid and its derivatives, as antioxidants, show promising potential for the treatment of Alzheimer's Disease.
CURRENT DRUG DELIVERY
(2022)
Article
Genetics & Heredity
Pelin Ercoskun, Cigdem Yuce Kahraman, Guller Ozkan, Abdulgani Tatar
Summary: In this study, novel pathogenic/likely pathogenic variants were identified in genes such as BRCA1, BRCA2, GALNT12, ATM, MLH1, MSH2, APC, and KIT, confirming the importance of NGS for risk assessment in cancer families. The majority of detected variants were found in the MUTYH, BRCA2, and CHEK2 genes. This study highlights the value of identifying disease-causing variants for treatment and prevention in hereditary cancer syndromes.
MOLECULAR SYNDROMOLOGY
(2022)
Article
Oncology
Ibrahim Sahin, Hanife Saat, Sercan Aksoy, Omer Dizdar, Haktan Bagis Erdem, Taha Bahsi
Summary: This study performed a comprehensive liquid biopsy panel on patients with lung and breast cancer and found that mutations in PIK3CA, PTEN, and RET were common in these patients. The results showed that sequencing of PIK3CA, PTEN, and RET could assess clinical characteristics and prognosis in patients with lung and breast cancer and potentially improve individual risk prediction, therapy, and prognosis.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Cigdem Yuce Kahraman, Gulden Sincan, Abdulgani Tatar
Summary: This study evaluated the relationship between JAK2 mutational burden and clinical parameters in MPN patients, and found a correlation between spleen size and LDH level with mutational burden. This relationship was more pronounced in PMF, and there was no significant association with vascular complications such as thrombosis and bleeding.
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
(2022)
Article
Oncology
Ibrahim Sahin, Hanife Saat, Sercan Aksoy
Summary: This study highlights the importance of recurrent germline mutations of BRCA1-2 in breast and ovarian cancer syndromes, and introduces the occurrence of these mutations in patients with Lynch syndrome for the first time.
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
(2022)
Article
Chemistry, Physical
Hasan Turkez, Mehmet Enes Arslan, Arzu Tatar, Ozlem Ozdemir, Erdal Sonmez, Kenan Cadirci, Ahmet Hacimuftuoglu, Bahattin Ceylan, Metin Acikyildiz, Cigdem Yuce Kahraman, Fatime Geyikoglu, Abdulgani Tatar, Adil Mardinoglu
Summary: Titanium diboride and zinc borate have many favorable properties and are widely used in various industries. However, their biomedical potentials are still unknown. This study found that titanium diboride and zinc borate nanoparticles did not have a cytotoxic effect on alveolar epithelial cell cultures. Titanium diboride nanoparticles enhanced the expression of cell adhesion molecules, proteases, and carrier proteins, while zinc borate nanoparticles affected the expression of genes related to the cell cycle, cell division, and extracellular matrix regulation. Exposure to titanium diboride and zinc borate nanoparticles may affect cellular mechanisms such as immunogenic responses, tissue regeneration, and cell survival.
Article
Dentistry, Oral Surgery & Medicine
Munevver Kilic, Taskin Gurbuz, Cigdem Yuce Kahraman, Atilla Cayir, Abdulbaki Bilgic, Yusuf Kurt
Summary: This study investigated the effects of taste gene polymorphisms on the dental status of obese and normal-weight children. The results showed that certain gene haplotypes were associated with dental caries, missing teeth, and obesity.
DENTAL AND MEDICAL PROBLEMS
(2022)
Article
Genetics & Heredity
Momen Kanjee, Cigdem Yuce Kahraman, Pelin Ercoskun, Abdulgani Tatar, Mustafa Kahraman
Summary: Agenesis of Corpus Callosum, Cardiac, Ocular, and Genital Syndrome (ACOGS) is a rare genetic disorder characterized by global developmental delay, agenesis or hypoplasia of corpus callosum, craniofacial dysmorphism, ocular, cardiac, and genital anomalies. In this study, we reported the fifteenth patient with ACOGS, who had a novel de novo nonsense variant in the CDH2 gene, and was the first patient from Turkey with a novel finding.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Medicine, General & Internal
Cigdem Yuce Kahraman, Gulden Sincan, Abdulgani Tatar
Summary: Myeloid malignancies are heterogeneous disorders characterized by defective hematopoiesis and myeloid differentiation. Next-generation sequencing panel testing allows for simultaneous screening of multiple mutations, providing clinicians with information for diagnosis, prognosis, and targeted treatment options, thus saving time and cost. This approach offers a powerful guide for clinicians in managing myeloid malignancies.
EURASIAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Ibrahim Sahin, Hanife Saat, Haktan Bagis Erdem, Taha Bahsi
Summary: A comprehensive liquid biopsy panel was performed on advanced resistant cancer patients to explore the challenges, limitations, and methods in liquid biopsy testing. The results showed the presence of different gene mutations and resistance mechanisms, emphasizing the importance of a comprehensive approach and personalized treatment strategies for cancer patients.
GAZI MEDICAL JOURNAL
(2022)