期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 17, 期 10, 页码 3652-3661出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2021.1932218
关键词
QIV; TIV; immunogenicity; safety; meta-analysis
资金
- Medical Science and Technology Innovation Project of Chinese Academy of Medical Sciences [2016-I2M-3-026]
- Innovation Team in Yunnan Province [2015HC027]
In this study, a meta-analysis was conducted to evaluate the immunogenicity and safety levels of human inactivated quadrivalent influenza vaccine in healthy adults. The results showed that the QIV produced similar immunogenicity and safety levels to the inactivated trivalent influenza vaccine, and had better immunogenicity against influenza B vaccine strains not included in the TIV.
Objective: The aim of the current study was to evaluate immunogenicity and safety levels of human inactivated quadrivalent influenza vaccine (QIV) which includes two A strains (A/H1N1, A/H3N2) and two B lineages (B/Victoria, B/Yamagata) in healthy adults via meta-analysis. Methods: Searches were conducted in PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE databases published in 2011-2020 according to inclusion and exclusion criteria. The purpose was to collect and perform meta-analysis of related randomized clinical trial (RCT) data concerning safety and immunogenicity levels of human QIV compared with inactivated trivalent influenza vaccine (TIV). Results: A total of 9 literatures were included. There was no significant difference in the seroconversion(SCR) and seroprotection(SPR) between QIV and TIV for influenza A strains (A/H1N1, A/H3N2) and the B lineage included in the TIV. QIV showed superior efficacy for the B lineage not included in the TIV: SCR RR of 2.20 (95%CI: 1.44-3.37, p = .0003) and SPR RR of 1.34 (95%CI: 1.10-1.63, p = .004) for B/Victoria, and SCR RR of 1.88 (95%CI: 1.53-2.31, p < .00001) and SPR RR of 1.11 (95%CI: 1.03-1.19, p = .006) for B/Yamagata, respectively. There were no significant differences between QIV and TIV for local and systemic adverse events(AE) post-vaccination. Conclusion: In adults 18-64 years old, QIV not only produced similar immunogenicity and safety levels to TIV, but also had better immunogenicity against influenza B vaccine strains not included in TIV.
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