Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

(2020) Wei-Jia Kong et al.   PHARMACOLOGY & THERAPEUTICS

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study

(2020) Ying-Xuan Chen et al.   Lancet Gastroenterology & Hepatology

Berberine pharmacology and the gut microbiota: A hidden therapeutic link

(2020) Solomon Habtemariam   PHARMACOLOGICAL RESEARCH

Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis

(2020) M. Leonor Fernández-Murga et al.   BONE

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

(2020) Yifei Zhang et al.   Nature Communications

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

(2019) Li-Shuang Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials

(2019) Kelly A. Tiderencel et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome

(2019) Martha Guevara‐Cruz et al.   Journal of the American Heart Association

The association between gut microbiota development and maturation of intestinal bile acid metabolism in the first 3 y of healthy Japanese infants

(2019) Masaru Tanaka et al.   Gut Microbes

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice

(2019) Wang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

(2019) Yan Liu et al.   Cell Metabolism

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020

(2019)   DIABETES CARE

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

(2019) Cai‐Na Li et al.   PHYTOTHERAPY RESEARCH

Microbiome and metabonomics study of quercetin for the treatment of atherosclerosis

(2019) Dong-Ning Wu et al.   Cardiovascular Diagnosis and Therapy

Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe −/− mice

(2018) Lin Zhu et al.   ATHEROSCLEROSIS

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway

(2018) Dan Liu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial

(2018) Jie Ming et al.   Trials

Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double-blind randomized controlled trial

(2018) Athasit Kijmanawat et al.   Journal of Diabetes Investigation

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids

(2018) Shi-Jun Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

(2018) Hong-Xin Cui et al.   Oxidative Medicine and Cellular Longevity

Pharmacological Applications of Bile Acids and Their Derivatives in the Treatment of Metabolic Syndrome

(2018) Maja Ðanić et al.   Frontiers in Pharmacology

Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

(2017) Fatemeh Famouri et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

(2017) Yan Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

(2017) Yanyun Gu et al.   Nature Communications

Gut Microbiota and Lifestyle Interventions in NAFLD

(2016) David Houghton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

(2016) Runbin Sun et al.   MOLECULAR PHARMACOLOGY

The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double-blind, randomized trial

(2016) Aline Corado Gomes et al.   Obesity

Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways

(2015) Yunli Yu et al.   BIOCHEMICAL PHARMACOLOGY

Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice

(2015) Thomas W Hoffmann et al.   ISME Journal

Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

(2015) Jiarong Lan et al.   JOURNAL OF ETHNOPHARMACOLOGY

MetaPhlAn2 for enhanced metagenomic taxonomic profiling

(2015) Duy Tin Truong et al.   NATURE METHODS

Transforming berberine into its intestine-absorbable form by the gut microbiota

(2015) Ru Feng et al.   Scientific Reports

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Functional Analysis of Family GH36 α-Galactosidases from Ruminococcus gnavus E1: Insights into the Metabolism of a Plant Oligosaccharide by a Human Gut Symbiont

(2012) M. Cervera-Tison et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

(2012) Xu Zhang et al.   PLoS One

Bifidobacterium adolescentis supplementation ameliorates visceral fat accumulation and insulin sensitivity in an experimental model of the metabolic syndrome

(2011) Jinjin Chen et al.   BRITISH JOURNAL OF NUTRITION

Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies

(2009) Yunli Yu et al.   BIOCHEMICAL PHARMACOLOGY

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

(2008) Yifei Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM