Article
Biochemistry & Molecular Biology
Maria Abellan-Alvaro, Guillermo Ayala, Manuela Barneo-Munoz, Fernando Martinez-Garcia, Carmen Agustin-Pavon, Enrique Lanuza
Summary: The study reveals significant differences in gene expression between lactating females expressing maternal aggression and pup-sensitized virgin females, with upregulation of genes encoding hormones and neuropeptides in dams, and downregulation of genes encoding inhibins and transcription factors. Gene set analysis also shows higher expression of Gene Ontology functional groups related to the Jak/Stat cascade in dams. Additionally, olfactory and vomeronasal receptor genes are expressed in the medial amygdala without differences between dams and virgins.
Article
Psychology, Developmental
Karim Ibrahim, Carla Kalvin, Fangyong Li, George He, Kevin A. Pelphrey, Gregory McCarthy, Denis G. Sukhodolsky
Summary: This study found sex-specific differences in gray matter volume and cortical thickness in prefrontal regions in boys with disruptive behavior disorders (DBD), but not girls. Dimensional analyses revealed associations between sex, callous-unemotional traits, and disruptive behavior.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Zi-Jun Wang, Treefa Shwani, Junting Liu, Ping Zhong, Fengwei Yang, Kelcie Schatz, Freddy Zhang, Arnd Pralle, Zhen Yan
Summary: Chronic social isolation stress during adolescence increases susceptibility to neuropsychiatric disorders. This study demonstrates that post-weaning isolation stress induces sex-specific behavioral abnormalities and changes in neuronal activity in the prefrontal cortex (PFC), basal lateral amygdala (BLA), and ventral tegmental area (VTA). The PFC to BLA pathway is causally linked to heightened aggression in stressed males, while the PFC to VTA pathway is causally linked to social withdrawal in stressed females. Furthermore, isolation stress leads to genome-wide transcriptional alterations, with upregulated genes in the BLA of stressed males controlled by the transcription factor CREB, and downregulated neuropeptide Hcrt (Hypocretin/Orexin) in the VTA of stressed females, which can be rescued by Orexin-A treatment.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Ana G. Cristancho, Natalia Tulina, Amy G. Brown, Lauren Anton, Guillermo Barila, Michal A. Elovitz
Summary: Sex-specific differences in behavior have been observed in children exposed to prenatal inflammation, with males showing increased anxiety and females experiencing decreased movement. The age of the individual also plays a role, with these behaviors manifesting differently in neonatal, juvenile, and adult animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Penghui Fan, Yilin Song, Botao Lu, Yiding Wang, Yuchuan Dai, Jingyu Xie, Enhui He, Zhaojie Xu, Gucheng Yang, Fan Mo, Juntao Liu, Mixia Wang, Xinxia Cai
Summary: This study explored the electrophysiological mechanism of the medial amygdala (MA) in innate fear through the use of modified microelectrode arrays (MEAs). The results showed that 2MT induced defensive behaviors in mice, accompanied by changes in the firing rate and local field potential of MA neurons.
FRONTIERS IN NEUROSCIENCE
(2022)
Letter
Psychiatry
Erin McGlade, Elliott Bueler, Jennifer DiMuzio, Chandni Sheth, Margaret Legarreta, Deborah Yurgelun-Todd
Summary: Female Veterans are the fastest growing demographic group in the Department of Veterans Affairs, with increasing suicide rates. The study found that male Veterans reported higher aggression levels compared to female Veterans, and lifetime suicidal behavior was associated with different types of aggression in males and females. These results suggest important differences in the association between aggression and suicidal behavior by sex, with implications for clinical practice.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Chang Peng, Tengyun Guo, Junhan Cheng, Mengni Wang, Fajuan Rong, Shiyang Zhang, Yafei Tan, Hongli Ding, Yan Wang, Yizhen Yu
Summary: This study explores the relationship between Internet addiction (IA) and aggression. The results show that IA is a strong predictor of aggression, but not all sub-types of aggression contribute to IA. Female individuals with IA are more likely to have increased risk of anger and indirect aggression, while having decreased risk of physical and verbal aggression compared to male individuals with IA.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Ellen P. Woon, Laura M. Butkovich, Arianna A. Peluso, Aziz Elbasheir, Kian Taylor, Shannon L. Gourley
Summary: We have discovered a connection between the ventral hippocampus and the medial orbitofrontal cortex that plays an important role in the updating of value memories, and this connection is mediated by the neuroplasticity-associated neurotrophin receptor TrkB.
Review
Cell Biology
Anna Carrano, Juan Jose Juarez, Diego Incontri, Antonio Ibarra, Hugo Guerrero Cazares
Summary: Sex differences exist in brain tumors, with males having higher incidence and worse outcomes in GBM compared to females. Estrogen plays a protective role in GBM, while upregulation of androgen receptors and testosterone may have detrimental effects. Hormones and the immune system play important roles in the GBM microenvironment.
Article
Behavioral Sciences
Narges Sotoudeh, Mohammad Reza Namavar, Farshid Bagheri, Asadollah Zarifkar
Summary: This study investigated the effect of aging and sex on the connectivity between the medial prefrontal cortex (mPFC) and medial amygdala (MeA) and its association with anxiety-like behavior. The results showed that old individuals had less anxiety-like behavior and a stronger mPFC-MeA connection. Young female rats were less anxious and had a stronger mPFC-amygdala connection than young males. The study suggests a negative relationship between anxiety levels and the mPFC-MeA connection based on the rat's performance in the open field test apparatus.
BRAIN AND BEHAVIOR
(2022)
Article
Biology
Maria Abellan-Alvaro, Fernando Martinez-Garcia, Enrique Lanuza, Carmen Agustin-Pavon
Summary: Repeated testing affects aggression in postpartum mice, with dams showing escalated aggression and virgins showing no aggression. The medial amygdala plays a key role in the expression of escalated aggression induced by repeated testing.
COMMUNICATIONS BIOLOGY
(2022)
Article
Behavioral Sciences
Candice L. Malone, Nathaniel S. Rieger, Jeremy A. Spool, Alexis Payette, Lauren V. Riters, Catherine A. Marler
Summary: Monogamous California mice exhibit behavioral convergence across two conspecific intruder challenges, which is associated with mRNA expression of oxytocin, androgen, and estrogen alpha receptors in the medial amygdala and anterior olfactory nucleus. This suggests the involvement of multiple mechanisms in behavioral convergence.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychology, Developmental
Margaret A. Mohr, Nancy Staffend Michael, Lydia L. DonCarlos, Cheryl L. Sisk
Summary: The rodent posterodorsal medial amygdala (MePD) plays a role in evaluating and assigning valence to social sensory stimuli. This study found that there are more pubertally born cells in the male MePD compared to the female MePD, indicating greater cell proliferation in males. Furthermore, the rate of cell attrition is higher in males. The differentiation of MePD cells into neurons or astrocytes within three weeks of birth showed no discernable sex differences. These findings suggest that pubertal neuro- and glio-genesis in the MePD may contribute to pubertal changes in the perception of social stimuli in both male and female rats.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Zhu Liu, Chun-Yan Wang, Yu Wang, Mei-Ting Cai, Wei-Xiang Zhong, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang, Bing-Xing Pan
Summary: Chronic stress exposure has differential effects on the output neurons of the medial prefrontal cortex (mPFC) in different subregions and layers. Specifically, chronic stress reduces inhibitory synaptic transmission onto the basolateral amygdala (BLA)-projecting neurons in the dorsomedial prefrontal cortex (dmPFC) layer V, leading to an imbalance of excitation and inhibition. However, chronic stress does not affect the excitation-inhibition balance in the nucleus accumbens (NAc)-projecting neurons in any subregions or layers of mPFC.
CELL AND BIOSCIENCE
(2023)
Article
Cell Biology
S. Kevin McCormick, Kay E. Holekamp, Laura Smale, Mary L. Weldele, Stephen E. Glickman, Ned J. Place
Summary: The apparent virilization of female spotted hyenas raises questions about sex differences in behavior and morphology. There is a mosaic of dimorphic traits in hyenas, conforming to some mammalian norms, but reversed in aggressive behavior, social dominance, and territory defense. Early androgen exposure enhances female hyenas' aggressiveness. Overall, masculinized behavioral traits in female hyenas are important for consistent food access, while unrelated traits conform to patterns of sexual dimorphism in other mammals.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Behavioral Sciences
Maria Gulinello, Heather A. Mitchell, Qiang Chang, W. Timothy O'Brien, Zhaolan Zhou, Ted Abel, Li Wang, Joshua G. Corbin, Surabi Veeraragavan, Rodney C. Samaco, Nick A. Andrews, Michela Fagiolini, Toby B. Cole, Thomas M. Burbacher, Jacqueline N. Crawley
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Behavioral Sciences
Meredith Goodrich, Anna Chelsea Armour, Karuna Panchapakesan, Xiaozhen You, Joseph Devaney, Susan Knoblach, Catherine A. W. Sullivan, Maria Jesus Herrero, Abha R. Gupta, Chandan J. Vaidya, Lauren Kenworthy, Joshua G. Corbin
Article
Pediatrics
Catherine S. Forster, Karuna Panchapakesan, Crystal Stroud, Payal Banerjee, Heather Gordish-Dressman, Michael H. Hsieh
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Article
Multidisciplinary Sciences
Jeremy Terrien, Isabelle Seugnet, Bolaji Seffou, Maria J. Herrero, James Bowers, Lamis Chamas, Stephanie Decherf, Evelyne Duvernois-Berthet, Chakib Djediat, Bertrand Ducos, Barbara A. Demeneix, Marie-Stephanie Clerget-Froidevaux
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Shahid Mohammad, Stephen J. Page, Li Wang, Seiji Ishii, Peijun Li, Toru Sasaki, Aiesha Basha, Anna Salzberg, Zenaide Quezado, Fumiaki Imamura, Hirotaka Nishi, Keiichi Isaka, Joshua G. Corbin, Judy S. Liu, Yuka Imamura Kawasawa, Masaaki Torii, Kazue Hashimoto-Torii
NATURE NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Katrina L. Adams, Giulia Riparini, Payal Banerjee, Marjolein Breur, Marianna Bugiani, Vittorio Gallo
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Maria Jesus Herrero, Dmitry Velmeshev, David Hernandez-Pineda, Saarthak Sethi, Shawn Sorrells, Payal Banerjee, Catherine Sullivan, Abha R. Gupta, Arnold R. Kriegstein, Joshua G. Corbin
Article
Multidisciplinary Sciences
Panagiotis Kratimenos, Evan Z. Goldstein, Ioannis Koutroulis, Susan Knoblach, Beata Jablonska, Payal Banerjee, Shadi N. Malaeb, Surajit Bhattacharya, M. Isabel Almira-Suarez, Vittorio Gallo, Maria Delivoria-Papadopoulos
Article
Physiology
Jack Falcon, Maria Jesus Herrero, Laura Gabriela Nisembaum, Esther Isorna, Elodie Peyric, Marilyn Beauchaud, Joel Attia, Denis Coves, Michael Fuentes, Maria Jesus Delgado, Laurence Besseau
Summary: The hormone melatonin plays a crucial role in regulating pituitary hormone production in European sea bass, influenced by factors like photoperiod, temperature, and salinity. Seasonal variations in mRNA abundance of pituitary hormones and melatonin receptors were observed in different fish groups raised in sea water and brackish water. In vitro experiments showed that melatonin's effects on pituitary hormones varied based on concentration, month investigated, and fish's prior adaptation to different salinities, highlighting the diverse responses of the pituitary gland in fish facing changing environmental conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Eliza M. Gordon-Lipkin, Payal Banerjee, Elizabeth Thompson, Shannon Kruk, Jose Luis Marin Franco, Peter J. McGuire
Summary: By studying children with mitochondrial disease (MtD) and a control group, it was found that OXPHOS deficiency leads to limitations in B cell function, which affects the generation of antibacterial antibodies and immune responses in children. Additionally, the timing of bacterial exposures was found to be asynchronous in children with MtD, suggesting different periods of increased exposure or susceptibility. This study is of significant importance in understanding the role of OXPHOS in B cell function.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Neurosciences
Luis E. F. Almeida, Li Wang, Sayuri Kamimura, Patricia M. Zerfas, Meghann L. Smith, Osorio L. Abath Neto, Ticiana Vale, Martha M. Quezado, Iren Horkayne-Szakaly, Paul Wakim, Zenaide M. N. Quezado