GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

(2021) Anders B. Klein et al.   Nature Communications

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

(2020) Tito Borner et al.   Cell Reports

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells

(2017) Asako Sasahara et al.   Oncotarget

GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF- RII heterodimer

(2016) A. Artz et al.   BLOOD

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

(2016) Mohammad Zarei et al.   DIABETES

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ

(2016) Nguan Soon Tan et al.   PROGRESS IN LIPID RESEARCH

Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease

(2016) Manuel Vázquez-Carrera   TRENDS IN ENDOCRINOLOGY AND METABOLISM

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

C6 ceramide dramatically increases vincristine sensitivity bothin vivoandin vitro, involving AMP-activated protein kinase–p53 signaling

(2015) Min-Bin Chen et al.   CARCINOGENESIS

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

(2015) K-W Min et al.   ONCOGENE

Targeting endoplasmic reticulum stress in insulin resistance

(2015) Laia Salvadó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2014) Laia Salvadó et al.   DIABETOLOGIA

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Growth Differentiation Factor (GDF)-15 Blocks Norepinephrine-induced Myocardial Hypertrophy via a Novel Pathway Involving Inhibition of Epidermal Growth Factor Receptor Transactivation

(2014) Xin-ye Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARδ activation attenuates hepatic steatosis inLdlr−/−mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

(2014) Lazar A. Bojic et al.   JOURNAL OF LIPID RESEARCH

Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Seung-Lark Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

HIV-1 Vpr Enhances PPARβ/δ-Mediated Transcription, Increases PDK4 Expression, and Reduces PDC Activity

(2013) Shashi Shrivastav et al.   MOLECULAR ENDOCRINOLOGY

Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity

(2013) Xingya Wang et al.   Obesity

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis

(2012) Heiko Johnen et al.   CARDIOVASCULAR PATHOLOGY

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

(2011) Min-Bin Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells

(2011) L. Serrano-Marco et al.   DIABETOLOGIA

The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

(2011) Emma Barroso et al.   ENDOCRINOLOGY

Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells

(2010) Teresa Coll et al.   ENDOCRINOLOGY

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts

(2008) Jianhai Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Identification of Macrophage Inhibitory Cytokine-1 in Adipose Tissue and Its Secretion as an Adipokine by Human Adipocytes

(2008) Qi Ding et al.   ENDOCRINOLOGY