IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

(2020) Kalil Alves de Lima et al.   NATURE IMMUNOLOGY

Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment

(2019) Claudia Cristiano et al.   BRITISH JOURNAL OF PHARMACOLOGY

IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease

(2019) Zhan Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

IL ‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response

(2019) Hung‐Chang Chen et al.   EMBO REPORTS

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

(2019) Miguel Ribeiro et al.   Science Immunology

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

(2018) Annika Sommer et al.   Cell Stem Cell

Sexual dimorphism in predisposition to Alzheimer's disease

(2018) Daniel W. Fisher et al.   NEUROBIOLOGY OF AGING

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Imbalance of Circulating Th17 and Regulatory T Cells in Alzheimer’s Disease: A Case Control Study

(2018) Timo Jan Oberstein et al.   Frontiers in Immunology

Autoimmune Manifestations in the 3xTg-AD Model of Alzheimer's Disease

(2018) Monica Marchese et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

(2017) Changchun Chen et al.   NATURE

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17–Producing γδ T Cells in Stroke

(2017) Priyadharshini Arunachalam et al.   STROKE

IL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling

(2017) Tao You et al.   Scientific Reports

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

(2016) Sachin P. Gadani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice

(2016) Y Lin et al.   Cell Death & Disease

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

(2016) S Monteiro et al.   Translational Psychiatry

The role of IL-17 in CNS diseases

(2015) Ari Waisman et al.   ACTA NEUROPATHOLOGICA

Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE

(2015) Julianne K. Hatfield et al.   CELLULAR IMMUNOLOGY

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

(2015) Seung-Hoon Yang et al.   Scientific Reports

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Increased Serum Levels of Interleukin-18, -23 and -17 in Chinese Patients with Alzheimer's Disease

(2014) Jin-Mei Chen et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

IL-17A Produced by    T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver

(2014) S. Hamada et al.   JOURNAL OF IMMUNOLOGY

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

(2013) Mi-Ae Lim et al.   EXPERIMENTAL GERONTOLOGY

TNF-  Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors

(2013) H. Pribiag et al.   JOURNAL OF NEUROSCIENCE

Measurement of choroid plexus perfusion using dynamic susceptibility MR imaging: capillary permeability and age-related changes

(2013) Roger Bouzerar et al.   NEURORADIOLOGY

CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia

(2013) Julian Zimmermann et al.   PLoS One

Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats

(2013) Jun Zhang et al.   PLoS One

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Age-associated alteration in naive and memory Th17 cell response in humans

(2011) Jin Soo Lee et al.   CLINICAL IMMUNOLOGY

Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents

(2011) Wen-Jie Ren et al.   NEUROPSYCHOPHARMACOLOGY

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction

(2010) C Corona et al.   Cell Death & Disease

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS