Article
Chemistry, Multidisciplinary
Tao Tang, Biao Huang, Feng Liu, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: This study proposes a strategy for the efficient delivery of nanoagents into tumors by regulating the NO-mediated tumor microenvironment. In mouse experiments, quantum dots and liposomes were encapsulated and loaded with L-arginine to continuously generate NO in the tumor, which activated metalloproteinases in the tumor microenvironment, degraded collagen I, and improved the accumulation and therapeutic efficacy of liposomes in the tumor.
Article
Nanoscience & Nanotechnology
Yuzhu Wang, Lu Jia, Tingting Hu, Zhuoran Yang, Chunyu Yang, Huiming Lin, Feng Zhang, Kai Yu, Fengyu Qu, Wei Guo
Summary: Although phototherapy has been extensively studied in recent years, its efficacy in treating tumors is often unsatisfactory due to the complex and variable tumor microenvironment. In this study, we report the discovery of novel hollow carriers named CoSn(OH)6@CoOOH with oxidase properties, which can enhance the effectiveness of phototherapy. These carriers react with oxygen to generate singlet oxygen and consume glutathione, and their hollow structure allows for the delivery of drug molecules. Loading indocyanine green and AIPH onto the carriers resulted in enhanced phototherapy effects through oxidase-catalyzed reactions, generation of alkyl radicals, and glutathione consumption. Cell and mouse experiments demonstrated that these carriers, combined with near-infrared laser irradiation, significantly inhibited tumor growth. Enrichment analysis revealed the involvement of the PI3K-Akt and MAPK signaling pathways in this therapeutic system. Hollow carriers with oxidase activity like these have great potential for the design of multifunctional drug delivery vehicles for tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Claire O. Kisamore, Brittany D. Elliott, A. Courtney Devries, Randy J. Nelson, William H. Walker II
Summary: Circadian rhythms are internal manifestations of the 24-h solar day that synchronize biological and behavioral processes to improve adaptive function and survival. Chronotherapy optimizes drug administration based on circadian rhythms to achieve maximum therapeutic efficacy and minimize side effects. This review examines the evidence for chronotherapeutic treatment for solid tumors, including chrono-chemotherapy, chrono-radiotherapy, and alternative chronotherapeutics, and discusses areas for further research and challenges in the field.
Article
Engineering, Biomedical
Feifan Zhou, Meng Wang, Teng Luo, Junle Qu, Wei R. Chen
Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.
Article
Biophysics
Xinyuan Li, Yan Wang, Tingting Liu, Yan Zhang, Chenhui Wang, Beibei Xie
Summary: The combination of chemotherapy and photothermal therapy is an effective approach for cancer treatment. Graphene oxide (GO) has been extensively used as a chemotherapeutic carrier and photothermal agent due to its large specific surface area and strong near-infrared absorbance. The preparation of ultrafine GO nanosheets (UGO) with controlled size and high oxidation degree is crucial for biological applications. In this study, a versatile drug delivery nanoplatform based on poly(dopamine) modified ultrasmall graphene oxide (UGO) was developed, which exhibited excellent biocompatibility, photothermal performance, and high drug loading capacity for doxorubicin. Under NIR laser irradiation, the photothermal-induced release of doxorubicin enabled efficient therapy of breast cancer by synergizing chemotherapy and photothermal therapy. This work establishes UGO as a novel drug delivery system with excellent photothermal performance for the combination therapy of tumors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Oncology
Tanios S. Bekaii-Saab, Rona Yaeger, Alexander I. Spira, Meredith S. Pelster, Joshua K. Sabari, Navid Hafez, Minal Barve, Karen Velastegui, Xiaohong Yan, Aditya Shetty, Hirak Der-Torossian, Shubham Pant
Summary: The study evaluated the clinical activity and safety of adagrasib in patients with other solid tumors harboring a KRAS(G12C) mutation. The results demonstrated encouraging clinical activity and good tolerability of adagrasib in this rare cohort of pretreated patients with KRAS(G12C)-mutated solid tumors.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Engineering, Environmental
Huixin Wang, Wenshen Wang, Chengpan Li, Ao Xu, Bensheng Qiu, Fenfen Li, Weiping Ding
Summary: This study presented a novel microneedle system loaded with the multipurpose small molecule Flav7 for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors, as well as remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Sen Liu, Can Shen, Dongsheng Jiang, Cheng Qian, Zhongmei Yang, Jianquan Wang, Wei Ye
Summary: This study combines chemotherapy with photothermal therapy to design a nanomedicine that utilizes heat and near infrared light for tumor thermal therapy and chemosensitization. By releasing CuS NPs and enhancing tumor penetration, it effectively eliminates tumor cells.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hyori Lee, Byullee Park, Jihye Lee, Yeoul Kang, Moongyu Han, Junseok Lee, Chulhong Kim, Won Jong Kim
Summary: This study designs a charge-convertible nanomedicine that facilitates deep penetration into solid tumors via transcytosis, providing a versatile theragnosis platform for noninvasive photoacoustic imaging and high therapeutic efficiency. The nanomedicine is an albumin-based calcium phosphate nanomedicine loaded with IR820 for high-resolution photoacoustic imaging and enhanced photothermal therapy. The pH-triggered transcytosis of the nanomedicine enabled by caveolae-mediated endocytosis and calcium ion-induced exocytosis is demonstrated in cellular, spheroid, and in vivo tumor models.
Article
Chemistry, Multidisciplinary
Xueru Song, Xiaoyu Zhou, Yunfeng Pan, Kaijie Liang, Yuting Luo, Wanrong Xie, Zhongyang Lv, Dingyi Yang, Yong Wang, X. S. Wu, Yizhang Wu, Jia Wei
Summary: Researchers have successfully developed a near-infrared responsive nanomaterial Schottky heterojunction, which can reshape the cold tumor microenvironment and achieve a vaccine-like antitumor effect. The nanomaterial not only improves photothermal conversion and reactive oxygen species generation, but also promotes antigen presentation and T cell infiltration through immune signaling pathways, leading to complete tumor ablation and systemic immune response activation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Sirong Zhou, Haoping Wang, Ruipeng Li, Yunxia Wang, Zhijun Wang, Liheng Feng
Summary: Incomplete local treatment is the main cause of difficult-to-cure solid tumors. In this work, a self-assembled biomaterial triggered by near-infrared light is developed, which effectively eliminates local lesions of solid tumors and improves the cure rate.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Banendu Sunder Dash, Gils Jose, Yu-Jen Lu, Jyh-Ping Chen
Summary: Nanomedicine using carbon-based nanomaterials, especially reduced graphene oxide (rGO), has shown promising potential in cancer therapy due to its ability to carry drugs and act as a photothermal agent. Functionalized rGO can be designed as multifunctional nanosystems with temperature/pH-dependent drug/gene delivery abilities for multimodal cancer therapy. Additional advantages like high biocompatibility, targeted delivery, and enhanced photothermal effects further enhance the potential of functionalized rGO in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Daniel J. Olson, Kunle Odunsi
Summary: The long-term benefits of immunotherapy have not extended to most nonhematologic solid tumors. Adoptive cell therapy has shown promising results in immunogenic tumors and has the potential to improve immune response in traditionally nonresponsive tumors. Challenges include manufacturing logistics, accurate antigen identification, and off-tumor toxicity risk. Continued advancements in cancer immunology and cell engineering may help extend the benefits of immunotherapy to more patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Giorgio Attina, Alberto Romano, Palma Maurizi, Sara D'Amuri, Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Antonio Ruggiero
Summary: Oral mucositis is a common complication of chemotherapy for childhood malignancies. The WHO oral mucositis scale is a valuable tool for assessing its severity in pediatric patients. In addition, WBS can be used as an assessment tool to determine the therapy for patients where direct evaluation of the oral cavity is not possible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shuyu Xu, Xiaoxiao Shi, En Ren, Jianzhong Zhang, Xing Gao, Dan Mu, Chao Liu, Gang Liu
Summary: This study presents a bioengineering-based smart enzymatic nanovesicle system, mHAase@nP18, which degrades the main component of tumor microenvironment hyaluronic acid (HA) to enhance tumor penetration and alleviate hypoxia, leading to enhanced sonodynamic therapy (SDT) effect.
ADVANCED FUNCTIONAL MATERIALS
(2022)
