Article
Cell & Tissue Engineering
Yi Li, Yujun Xu, Xinhan Liu, Xin Yan, Yue Lin, Qian Tan, Yayi Hou
Summary: The study found that the wound healing process in diabetic patients is slow, with abnormal accumulation of MDSCs and activation of the mTOR signaling pathway. Treatment with the mTOR signaling inhibitor INK128 can reduce MDSCs and promote wound healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Xiaoxue Li, Changwei Liu, Yiwen Zhu, Hanyu Rao, Min Liu, Liming Gui, Wenxin Feng, Huayuan Tang, Jin Xu, Wei-Qiang Gao, Li Li
Summary: The study revealed that the loss of SETD2 promotes cutaneous wound healing by activating the AKT/mTOR signaling pathway, leading to accelerated keratinocyte proliferation and migration.
CELL PROLIFERATION
(2021)
Article
Chemistry, Multidisciplinary
Ya-Jun Fu, Yi-Feng Shi, Li-Ya Wang, Yi-Fan Zhao, Rao-Kaijuan Wang, Kai Li, Shu-Ting Zhang, Xiang-Jun Zha, Wei Wang, Xing Zhao, Wei Yang
Summary: Macrophages in diabetic wounds can be divided into pro-inflammatory M1 and anti-inflammatory M2 types. Hydrogel dressings with the ability to regulate macrophage heterogeneity show potential in promoting diabetic wound healing. An all-natural hydrogel has been developed, which can convert M1 macrophages into M2 macrophages without additional ingredients or external intervention, providing a simple and safe approach for accelerating wound healing.
Review
Chemistry, Multidisciplinary
Jiayi Mao, Lu Chen, Zhengwei Cai, Shutong Qian, Zhimo Liu, Binfan Zhao, Yuguang Zhang, Xiaoming Sun, Wenguo Cui
Summary: The review discusses the use of macrophage immunotherapy in promoting wound healing, as well as the importance of biomaterials in regulating macrophage signaling for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Zilong Fang, Tao Lin, Shuai Fan, Xing Qiu, Ziqing Zhong, Ganghua Yang, Jianqiu Yang, Guoqing Zhang, Yang Feng, Fanrong Ai, Qingming Shi, Wenbing Wan
Summary: This study discovered and constructed a novel injectable hydrogel wound dressing based on carboxymethyl chitosan (CMCS) and polyethylenimine (PEI). The hydrogel has good injectability, biocompatibility, antibacterial properties, and certain adhesion properties, which can promote wound healing and cell repair with broad application prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Wangbei Cao, Shiqiao Peng, Yuejun Yao, Jieqi Xie, Shifen Li, Chenxi Tu, Changyou Gao
Summary: A wound dressing with immunomodulation and electroconductivity properties was prepared and tested for its effectiveness in promoting diabetic wound healing. The dressing successfully accelerated skin regeneration, collagen deposition, revascularization, and re-epithelialization in diabetic wounds. It achieved this by regulating the wound microenvironment, scavenging reactive oxygen species (ROS), and polarizing macrophages to the M2 phenotype.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Mingqian Hao, Chuanbo Ding, Shuwen Sun, Xiaojuan Peng, Wencong Liu
Summary: In this study, the chitosan/sodium alginate/velvet antler blood peptides (CS/SA/VBPs) hydrogel (CAVBPH) was used for the first time in the treatment of skin wounds in type 2 diabetes mellitus (T2D). The results indicate that CAVBPH is a promising wound dressing that promotes diabetic wound healing through regulating angiogenesis, inflammatory response, and skin flora.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Engineering, Environmental
Kai Wang, Ruonan Dong, Jiezhang Tang, Huichen Li, Juanli Dang, Zhaoxiang Zhang, Zhou Yu, Baolin Guo, Chenggang Yi
Summary: This study developed a self-healing hydrogel capable of stably releasing exosomes to enhance diabetic wound healing. Through the synergistic effect of exosome release and M2 macrophage polarization, it accelerated angiogenesis and wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Gianluca Antonio Franco, Alessia Arangia, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Daniela Impellizzeri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Recently, wound healing has become a topic of increased interest in both scientific and clinical communities. The study aimed to investigate the molecular mechanism of acai berry in wound healing using a mouse model. The results showed that acai berry could modulate the Wnt/beta-catenin pathway, reducing the expression of Wnt3a and FZ8, and the accumulation of beta-catenin. It also showed anti-inflammatory activities by reducing the expression of TNF-alpha and IL-18, and modulating the NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Hung Lee, Dong-Yi Chen, Ming-Jer Hsieh, Kuo-Chun Hung, Shu-Chun Huang, Chia-Jung Cho, Shih-Jung Liu
Summary: This study developed an advanced and encouraging vehicle to improve clinically applicable diabetic wound care. Nanofibrous insulin/vildagliptin core-shell biodegradable (PLGA) scaffolds were prepared to deliver vildagliptin and insulin for the repair of diabetic wounds. The core-shell nanofibrous scaffolds released vildagliptin and insulin effectively and accelerated wound healing. The insulin/vildagliptin-loaded core-shell nanofibers extended drug delivery and enhanced wound repair associated with diabetes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Yang Liu, Lida Liao, Changming An, Xiaolei Wang, Zhengjiang Li, Zhengang Xu, Jie Liu, Shaoyan Liu
Summary: The study discovered that ENO1 overexpression promoted the growth and invasion of thyroid carcinoma cells, while depletion of ENO1 inhibited cell proliferation and migration; the hypoxia-related mTOR/HIF1 pathway regulated ENO1 expression, and ENO1 influenced the expression of CST1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Rong Nie, Qing-Yi Zhang, Jie Tan, Zi-Yuan Feng, Kai Huang, Ning Sheng, Yan-Lin Jiang, Yu-Ting Song, Chen-Yu Zou, Long-Mei Zhao, He-Xi Li, Rui Wang, Xing-Li Zhou, Juan-Juan Hu, Chen-Yu Wu, Li-Ling Jesse, Hui-Qi Xie
Summary: This study demonstrates that epigallocatechin gallate (EGCG) modification of decellularized porcine small intestinal submucosa (SIS) improves its antioxidant and immunomodulatory capacities, thereby enhancing its therapeutic potential for wound healing.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Polymer Science
Rikako Hama, Derya Aytemiz, Kelvin O. Moseti, Tsunenori Kameda, Yasumoto Nakazawa
Summary: Silk fibroin (SF) has great potential as a biomaterial due to its shape and structure. This study successfully modified SF with heparin using tyrosine residues as reaction points, which improved its ability to bind to high-molecular-weight and hydrophilic compounds. Increased heparin modification led to higher heparin content and improved water wettability on film surfaces, promoting the proliferation of endothelial cells and fibroblasts.
Article
Chemistry, Multidisciplinary
Huiqun Hu, Danni Zhong, Wanlin Li, Xiuhui Lin, Jian He, Yuchao Sun, Yuan Wu, Minqi Shi, Xiaoyuan Chen, Feng Xu, Min Zhou
Summary: A multifunctional quorum sensing (QS) inhibitor based on a bioactive hydrogel system was developed to accelerate wound healing. The gel was found to synergistically inhibit the QS of bacteria, destroy biofilm formation, and promote wound healing by releasing specific substances and generating reactive oxygen species.
