Article
Medicine, General & Internal
Noemi Salmeri, Gianluca Gennarelli, Valeria Stella Vanni, Stefano Ferrari, Alessandro Ruffa, Patrizia Rovere-Querini, Luca Pagliardini, Massimo Candiani, Enrico Papaleo
Summary: This study investigated the additional impact of co-existing autoimmunity in women with endometriosis on the early stages of reproduction. The study found significantly lower cleavage and implantation rates among women with endometriosis and concomitant autoimmunity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Hila Greenbaum, Bat-El Lugassy Galper, Dean H. Decter, Vered H. Eisenberg
Summary: This study indicates that autoantibodies may be effective non-invasive markers for earlier detection of endometriosis. Current literature suggests that various anti endometrial antibodies may be used for adjunctive diagnosis, with some antibodies being particularly important for early detection in mild endometriosis.
AUTOIMMUNITY REVIEWS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giacomo Rebella, Nicola Romano, Giulia Silvestri, Jean Louis Ravetti, Gabriele Gaggero, Liliana Belgioia, Francesco Lupidi, Alessio Signori, Luca Roccatagliata, Laura Saitta, Lucio Castellan
Summary: This study verified the incidence of calcified brain metastases (CBM) as 9.5% in patients with brain metastases, mainly in lung adenocarcinoma, breast ductal invasive carcinoma, and small cell lung carcinoma. The majority of CBM were single and there were no specific correlations between calcification type and histology of primary tumor.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarah Ballou, Rafla Hassan, Judy Nee, Johanna Iturrino, Vikram Rangan, Vivian Cheng, Lisa Conboy, Irving Kirsch, Anthony Lembo, Ted J. Kaptchuk, John Kelley
Summary: This study analyzed data from a clinical trial of irritable bowel syndrome and found that participants often experienced extra-intestinal symptoms at baseline, which generally improved over the course of the trial. Therefore, systematic assessment of these symptoms at the beginning of a clinical trial is necessary.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Computer Science, Information Systems
Ghazal Zamani, Olivia Das
Summary: A fault management system with distributed architecture may enhance scalability, but also make application recovery dependent on the system itself. This study introduces two new equations to meet performance objectives and suggests that the interconnection topology and parameter values of management architecture could have a significant impact on application's performance. Additionally, simulation results show that simply increasing the number of managers may not always be beneficial.
JOURNAL OF GRID COMPUTING
(2021)
Article
Oncology
Hejuan Hu, Bai Ling, Yuhan Shi, Haohao Wu, Bingying Zhu, Yiling Meng, Guo-Ming Zhang
Summary: Plasma exosome-derived SENP1 levels were significantly elevated in melanoma patients compared to healthy controls. Higher levels of plasma exosome-derived SENP1 were associated with worse disease-free survival and overall survival in melanoma patients, suggesting a potential prognostic value for predicting the 3-year outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Li-Ying OuYang, Zi-Jian Deng, Yu-Feng You, Jia-Ming Fang, Xi-Jie Chen, Jun-Jie Liu, Xian-Zhe Li, Lei Lian, Shi Chen
Summary: The study aims to predict the prognosis and immune therapy response for esophagogastric junction adenocarcinoma (EGJA) by constructing a SIRGs score. High SIRGs score is significantly associated with immunotherapy response and can improve the accuracy of clinical prediction models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Cuiyan Tan, Xiaobin Zheng, Fengfei Sun, Jianzhong He, Honglei Shi, Meizhu Chen, Changli Tu, Yiying Huang, Zhenguo Wang, Yingjian Liang, Jian Wu, Ye Liu, Jing Liu, Jin Huang
Summary: Research found significantly higher levels of SP-IgE and NP-IgE in severe COVID-19 cases, correlated with disease severity. Airway hyperresponsiveness was present in early convalescence, supporting hypersensitivity as a potential mechanism in severe COVID-19.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Clinical Neurology
Marta Garcia-Montojo, Elena Rita Simula, Saeed Fathi, Cynthia McMahan, Anubrata Ghosal, James D. Berry, Merit Cudkowicz, Abdel Elkahloun, Kory Johnson, Gina Norato, Peter Jensen, Tony James, Leonardo A. Sechi, Avindra Nath
Summary: This study found that individuals with amyotrophic lateral sclerosis (ALS) had a stronger antibody response against HML-2 env compared to healthy controls. Lower levels of HML-2 antibodies in ALS were associated with poor prognosis and decreased survival probability.
ANNALS OF NEUROLOGY
(2022)
Article
Immunology
Yue Zhou, Xuelian Liao, Xiangrong Song, Min He, Fei Xiao, Xiaodong Jin, Xiaoqi Xie, Zhongwei Zhang, Bo Wang, Chenliang Zhou, Yan Kang, Wei Zhang
Summary: During the COVID-19 pandemic, some critically ill patients were unable to be discharged from the ICU despite negative viral tests, leading to a study on the gene expression profiles of peripheral immune cells. The findings showed severely decreased expression of adaptive immunity-related genes in these patients, particularly related to T/B cells and HLA molecules, resulting in long-term secondary infections. No significant change was observed in classic immunosuppression molecules, suggesting that this adaptive immune suppression may be caused by dysregulated host response to severe infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Maria Zervou, Dimitrios Vlachakis, Louis Papageorgiou, Elias Eliopoulos, George N. Goulielmos
Summary: This review highlights the shared genetic factors between RA and endometriosis, suggesting a potential genetic basis for both diseases. The abnormal immune system and increased risk observed in both diseases indicate a possible connection.
Article
Medicine, General & Internal
Wei Zhu, Zhanqi Wei, Tianjun Zhou, Chang Han, Zehui Lv, Han Wang, Bin Feng, Xisheng Weng
Summary: This study found that preoperative bone density values of the femoral greater trochanter and sex could be promising independent predictors for bleeding during total hip arthroplasty (THA) surgery. Osteoporosis and female patients might have lower blood loss in THA operation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Molly M. Quinn, Richard J. Paulson
Summary: This study aimed to explore the impact of high-dose gonadotropin on stimulation outcomes and found that it does not cause apparent harm to poor-to-moderate responders. There is no compelling data to suggest that mild stimulation is superior. Additionally, more gonadotropin may have benefits in specific clinical scenarios.
FERTILITY AND STERILITY
(2023)
Article
Business
Shiau-Ling Guo
Summary: Research on contractual governance has traditionally focused on the mutual effects of exchange hazards on contractual design at the transaction level. However, this paper takes a departure from the traditional approach and examines the impact of idiosyncratic exchange hazards on divergent contractual arrangement interests within interorganizational relationships. By adopting a dyadic perspective, the study sheds light on the discriminatory alignment principle and provides insights into intentionally leaving gaps in contracts to control the threat of exchange hazards.
LONG RANGE PLANNING
(2023)
Article
Anesthesiology
Emerson Krock, Carlos E. Morado-Urbina, Joana Menezes, Matthew A. Hunt, Angelica Sandstroem, Diana Kadetoff, Jeanette Tour, Vivek Verma, Kim Kultima, Lisbet Haglund, Carolina B. Meloto, Luda Diatchenko, Eva Kosek, Camilla I. Svensson
Summary: Transferring fibromyalgia patient immunoglobulin G (IgG) to mice induces pain-like behavior, indicating the potential role of autoantibodies in fibromyalgia pathology. Elevated levels of anti-SGC IgG were found in fibromyalgia patients and were associated with more severe symptoms. Screening for anti-SGC antibodies could help personalize treatment options for fibromyalgia.
Article
Obstetrics & Gynecology
N. Salmeri, J. Ottolina, L. Bartiromo, M. Schimberni, C. Dolci, S. Ferrari, R. Villanacci, S. Arena, N. Berlanda, L. Buggio, A. Di Cello, E. Fuggetta, F. Maneschi, C. Massarotti, A. Mattei, F. Perelli, I Pino, M. G. Porpora, D. Raimondo, V Remorgida, R. Seracchioli, A. Ticino, P. Vigano, M. Vignali, F. Zullo, E. Zupi, L. Pagliardini, M. Candiani
Summary: This study aimed to assess the association of certain somatic phenotypes with specific localizations of endometriosis. It found that green eyes and blonde/light brown hairs may be associated with a higher risk of ureteral endometriosis.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Genetics & Heredity
Noemi Salmeri, Ilma Floriana Carbone, Paolo Ivo Cavoretto, Antonio Farina, Danila Morano
Summary: Fetal growth restriction is a complex condition with multifactorial etiology, involving factors from the fetus, mother, and placenta. Recent studies have highlighted the crucial role of the placenta in fetal programming and its impact on the adult life phenotype of the fetus. Epigenetic mechanisms may be associated with fetal growth restriction.
MOLECULAR DIAGNOSIS & THERAPY
(2022)
Article
Acoustics
P. I. Cavoretto, N. Salmeri, M. Candiani, A. Farina
Summary: This study provides gestational-age specific reference ranges for mean uterine artery pulsatility index (UtA-PI) based on longitudinal data assessment throughout pregnancy. The results show a progressive non-linear decrease in UtA-PI during pregnancy, and the new reference ranges may have better performance in screening for placenta-associated diseases and evaluating the potential risk for pregnancy-induced hypertension and/or small-for-gestational age.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Surgery
Francesco Vito Mandarino, Alberto Barchi, Lorenzo Leone, Lorella Fanti, Francesco Azzolini, Edi Viale, Dario Esposito, Noemi Salmeri, Francesco Puccetti, Lavinia Barbieri, Andrea Cossu, Elio Treppiedi, Ugo Elmore, Riccardo Rosati, Silvio Danese
Summary: Treatment of anastomotic leaks after Ivor-Lewis esophagectomy remains challenging. This study compares intracavitary endoscopic vacuum therapy (EVT) with self-expandable metal stent (SEMS) for the treatment of leaks < 30 mm, as there is limited data on this topic.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Multidisciplinary Sciences
Noemi Salmeri, Letizia Li Piani, Paolo Ivo Cavoretto, Edgardo Somigliana, Paola Vigano, Massimo Candiani
Summary: The risk of gestational diabetes mellitus (GDM) is significantly higher in women with endometriosis, especially in more severe stages of the disease. This association is present in naturally conceived pregnancies but not in pregnancies conceived through assisted reproductive technologies (ART).
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Noemi Salmeri, Gianluca Gennarelli, Valeria Stella Vanni, Stefano Ferrari, Alessandro Ruffa, Patrizia Rovere-Querini, Luca Pagliardini, Massimo Candiani, Enrico Papaleo
Summary: This study investigated the additional impact of co-existing autoimmunity in women with endometriosis on the early stages of reproduction. The study found significantly lower cleavage and implantation rates among women with endometriosis and concomitant autoimmunity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Massimo Candiani, Jessica Ottolina, Noemi Salmeri, Sara D'Alessandro, Iacopo Tandoi, Ludovica Bartiromo, Matteo Schimberni, Stefano Ferrari, Roberta Villanacci
Summary: Minimally invasive surgery is a safe and effective technique that requires smaller incisions and shorter hospital stays compared to traditional surgery. In gynecology, it is now being used to treat infertility in young women with unexplained infertility or suspected endometriosis. The two surgical procedures commonly used for ovarian endometriosis are laparoscopic cystectomy and laparoscopic CO2 fiber laser vaporization.
FRONTIERS IN SURGERY
(2023)
Review
Endocrinology & Metabolism
Noemi Salmeri, Paola Vigano, Paolo Cavoretto, Roberto Marci, Massimo Candiani
Summary: Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with opposite alterations in reproductive processes and phenotypic traits. Recent discovery of kisspeptin as a pivotal mediator in human reproduction and its involvement in metabolism, inflammation, and pain sensitivity provides new insights into understanding these conditions. This review discusses the clinical relevance and potential translational applications of these discoveries in developing novel therapies for endometriosis and PCOS.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Obstetrics & Gynecology
Noemi Salmeri, Massimo Candiani, Paolo Ivo Cavoretto
Summary: SARS-CoV-2 infection increases the risk of adverse pregnancy outcomes for both mothers and fetuses. A recent study in BMC Pregnancy and Childbirth used a machine learning algorithm to predict this risk. This commentary discusses the potential implications and applications of this research for future global health policies.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Microbiology
Noemi Salmeri, Emanuele Sinagra, Carolina Dolci, Giovanni Buzzaccarini, Giulio Sozzi, Miriam Sutera, Massimo Candiani, Federica Ungaro, Luca Massimino, Silvio Danese, Francesco Vito Mandarino
Summary: Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, with gut dysbiosis playing a significant role in both diseases. Emerging research has shown distinct differences in gut microbiota composition between healthy individuals and those with endometriosis or IBS. Intestinal dysbiosis impacts intestinal permeability, triggers inflammation, and affects the gut-brain axis, highlighting the potential for microbiota-focused therapies.
Article
Obstetrics & Gynecology
Massimo Candiani, Stefano M. Ferrari, Noemi Salmeri, Carolina Dolci, Roberta Villanacci, Ludovica Bartiromo, Matteo Schimberni, Iacopo Tandoi, Enrico Papaleo, Jessica Ottolina
Summary: This study compared ovarian responsiveness in infertile women undergoing assisted reproductive techniques (ART) with different management approaches for ovarian endometriomas. The results showed that after CO2 fiber laser ablation, the quality of eggs and embryos developed in vitro was better, while surgical removal of endometrioma resulted in a decrease in the quantity of eggs and embryos.
MINERVA OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
G. Buzzaccarini, G. Grecchi, G. A. Papa, G. Carnemolla, N. Salmeri, R. Villanacci, P. Giardina, S. D'Alessandro, M. Molgora, D. Marzanati, L. Pagliardini, V. S. Vanni, A. Alteri, M. Candiani, E. Papaleo
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
N. Salmeri, V. S. Vanni, J. Ottolina, L. Pagliardini, S. Ferrari, D. Delprato, P. Rovere Querini, A. Rebecchi, C. Patruno, C. Dolci, M. Candiani, E. Papaleo
HUMAN REPRODUCTION
(2022)
Meeting Abstract
Obstetrics & Gynecology
C. Dolci, V. S. Vanni, E. Papaleo, L. Pagliardini, G. Cermisoni, N. Salmeri, A. Salonia, M. Candiani
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Noemi Salmeri, Margherita Papale, Cristina Montresor, Massimo Candiani, Elisabetta Garavaglia
Summary: This study provides a summary of the clinical presentation and management experiences of uterine arteriovenous malformations (UAVM) in cases of unexplained post-partum hemorrhage (PPH). The findings suggest that UAVM should be considered as a possible cause of unexplained PPH in clinical practice.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)