Article
Immunology
Akira Hasegawa, Daichi Utsumi, Kaare Lund, Mitsuhiro Okano, Katsuyo Ohashi-Doi, Kimihiro Okubo
Summary: In Japanese HDM allergic rhinitis patients without asthma, there is a high prevalence of allergic sensitization to the HDM major allergens Der p 1, Der p 2, and Der p 23, with a significantly higher prevalence of Der p 23 sensitization in the younger age group. However, there was no significant correlation found between AR symptom scores and concentration of s-IgE towards Der p extract and any of the three HDM major allergens in this population.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rei-Hsing Hu, Chun-Wen Cheng, Chia-Ta Wu, Jiunn-Liang Ko, Ko-Huang Lue, Yu-Fan Liu
Summary: House dust mites (HDMs) are a significant cause of allergies and asthma. In central Taiwan, approximately 80% of individuals are sensitized to a particular mite species called Dermatophagoides microceras (Der m). This sensitivity is related to the immune response to other mite species. A study used integrated OMICs examination to identify and characterize a specific allergen component, Der m 1. The study found that Der m 1 is a cysteine protease and plays a role in the digestion of fibrinogen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Construction & Building Technology
Donghyun Kim, Ji Young Park, Dong Hyun Lee, Jae-Eun Lim, Hyo-Bang Moon, Sungkyoon Kim, Kiyoung Lee
Summary: This study investigated settled house dust (SHD) samples collected from 106 houses in Seoul and Gyeonggi Province, Korea, and found various chemical and biological contaminants in the dust, with the highest concentrations detected for organophosphate flame retardants, phthalates, alternative plasticizers, and trace metals. The study also identified significant associations between the concentrations of contaminants in the dust and factors such as the type and number of electronic appliances and combustion activities, while ventilation, vacuum cleaning, and wet cleaning or dry mopping were found to significantly reduce the levels of contaminants in the dust.
Article
Biochemistry & Molecular Biology
Huey-Jy Huang, Eszter Sarzsinszky, Susanne Vrtala
Summary: House dust mite (HDM) allergy is a significant global health concern, affecting approximately 65-130 million people worldwide and potentially leading to severe conditions like atopic dermatitis or asthma. Current diagnosis and immunotherapy methods are hindered by poor quality and inadequate allergens in mite extracts. Using individual allergens as an alternative shows promise due to their well-defined components that can be easily produced and quantified. However, thorough characterization of these individual allergens is necessary for determining their clinical relevance in diagnosing HDM allergy and ensuring successful immunotherapy.
MOLECULAR IMMUNOLOGY
(2023)
Article
Food Science & Technology
Sara Benede, Leticia Perez-Rodriguez, Monica Martinez-Blanco, Elena Molina, Rosina Lopez-Fandino
Summary: Orally administered HDM can promote inflammatory and type 2 responses in the intestine, affecting the expression of genes encoding tight junction proteins and cytokines, and activating innate immune cells. However, there is no evidence of HDM promoting sensitization to coadministered proteins in our experimental setting.
Article
Veterinary Sciences
Jihee Kim, Ji-Hye Lee, Yunji Song, Ha-Jung Kim
Summary: This study analyzed the correlation between indoor house dust mite (HDM) concentration, canine atopic dermatitis (CAD) severity, and residential environments in 35 CAD dogs and 13 healthy dogs. The results showed that Der f 1 concentration had a negative association with transepidermal water loss (TEWL), but no association with CAD severity index-04 (CADESI-04) and pruritus visual analog scale (PVAS). Der f 1 concentration was significantly higher in the group living near green areas and with indoor relative humidity (RH) ≥40%. The study suggests that living near green areas and maintaining appropriate indoor climate may improve CAD clinical symptoms, and high concentrations of HDM may enhance the skin barrier function.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Angelica Papanicolaou, Hao Wang, Jonathan McQualter, Christian Aloe, Stavros Selemidis, Catherine Satzke, Ross Vlahos, Steven Bozinovski
Summary: Allergic airway disease diminishes the control of pneumococcal lung infections, and exposure to house dust mites exacerbates the immune response, leading to more severe infections and increased airway hyperresponsiveness.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jinjoo Kang, Soyoung Lee, Namkyung Kim, Hima Dhakal, Young-Ae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: The study investigated the efficacy of Hispidulin on atopic dermatitis-like skin inflammation, suggesting that HPD could be a potential drug candidate for the treatment of AD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner
Summary: The local synthesis of glucocorticoids in the lung plays an important role in the regulation of allergic airway inflammation, particularly in HDM-induced airway hypersensitivity, by controlling Toll-like receptor 4 signaling and cytokine/chemokine secretion to influence Th17-type immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hanene Bzioueche, Myriam Tamelghaghet, Berengere Chignon-Sicard, Noemie Bazile, Pauline Hauchecorne, Maria Barbero Calderon, Pauline Meunier, Stephane Rocchi, Thierry Passeron, Meri K. Tulic
Summary: Ceramides are crucial for the barrier function of normal skin. Reduced ceramide levels are associated with atopic dermatitis. This study examined the impact of house dust mite (HDM) on skin integrity and the effect of different ceramides on HDM-induced skin damage. The presence of Ceramide AD (TM) in a cream inhibited HDM-induced damage and restored skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Wai Lok So, Wenyan Nong, Yichun Xie, Tobias Baril, Hai-yao Ma, Zhe Qu, Jasmine Haimovitz, Thomas Swale, Juan Diego Gaitan-Espitia, Kwok Fai Lau, Stephen S. Tobe, William G. Bendena, Zhen-peng Kai, Alexander Hayward, Jerome H. L. Hui
Summary: Myriapods, specifically centipedes and millipedes, have undergone rapid genome evolution shaped by ecological pressures. The differences in their genomic pathways are a result of their divergence from the myriapod ancestor.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Matheus Fonseca Aarestrup, Paula Fonseca Aarestrup, Mariana Senff de Andrade, Beatriz Juliao Aarestrup, Akinori Cardozo Nagato, Fernando Monteiro Aarestrup
Summary: Research has shown that allergic patients undergoing house dust mite SLIT generally have a high perception of satisfaction regarding treatment effectiveness, improvement in daily activities, cost-benefit balance, and overall satisfaction.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Patricia Macchiaverni, Ulrike Gehring, Akila Rekima, Alet H. Wijga, Valerie Verhasselt
Summary: This study investigated the relationship between exposure to house dust mite Der p 1 allergen from different sources during infancy and IgE levels and asthma outcomes in children. The findings suggest that exposure to Der p 1 through human milk is associated with high levels of serum IgE in childhood, while exposure from mattress dust is not.
Article
Allergy
Saliha Ait Yahia, Camille Audousset, Daniel Alvarez-Simon, Han Vorng, Dieudonnee Togbe, Philippe Marquillies, Myriam Delacre, Stephanie Rose, Helene Bouscayrol, Aline Rifflet, Valerie Quesniaux, Ivo Gomperts Boneca, Mathias Chamaillard, Anne Tsicopoulos
Summary: The study found that NOD1-dependent sensing of gram-negative bacteria associated with HDM exacerbates the severity of experimental asthma, suggesting that inhibiting the NOD1 signaling pathway may be a therapeutic approach to treating asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed H. Shamji, Ioana Agache, Andre Moreira
Summary: This study compared the cost-effectiveness of allergen immunotherapy (AIT) to standard treatment in children with allergic asthma. The results showed that AIT, especially when administered subcutaneously, was cost effective in reducing asthma exacerbations and medication use.
Correction
Cell Biology
Wei Song, Jan A. Veenstra, Norbert Perrimon
Article
Genetics & Heredity
Jia Xie, Ming Sang, Xiaowen Song, Sisi Zhang, Donghun Kim, Jan A. Veenstra, Yoonseong Park, Bin Li
Article
Endocrinology & Metabolism
Sifang Liao, Stephanie Post, Philipp Lehmann, Jan A. Veenstra, Marc Tatar, Dick R. Nassel
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Anastasia Herrero, Taishi Yoshii, Juan Ignacio Ispizua, Carina Colque, Jan A. Veenstra, Nara Muraro, Maria Fernanda Ceriani
Article
Biochemistry & Molecular Biology
Jan A. Veenstra
Summary: The SMYamide genes in the American cockroach exhibit similarities to the SIFamide genes and may have hormonal functions, as they are released into the hemolymph during feeding. Additionally, the presence of SIFamide receptors in various tissues suggests that SMYamide plays a significant role in endocrine regulation in this species.
Article
Biochemistry & Molecular Biology
Paolo Cuti, Miquel Barbera, Jan A. Veenstra, David Martinez-Torres
Summary: Aphids undergo a seasonal switch from viviparous parthenogenesis to sexual reproduction in response to changing photoperiods, possibly mediated by two insulin-like peptides (ILP1 and ILP4). ILP4 is synthesized in specific neurosecretory cells in the aphid brain and transported to the corpora cardiaca and abdomen, suggesting a direct connection between neurosecretory cells and the reproductive system. Additionally, collateral arborizations from the neurosecretory cells to areas containing clock neurons and photoreceptors hint at a possible communication between circadian and photoperiodic systems.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jan A. Veenstra, Jimena Leyria, Ian Orchard, Angela B. Lange
Summary: Several genes related to insulin have been identified in the migratory locust, including gonadulin and aIGF. These genes are expressed in various tissues, with gonadulin specifically expressed in the ovary and its receptor transcript abundantly expressed in the ovary, fat body, and central nervous system. The central nervous system-fat body-ovary axis plays a crucial role in reproduction, indicating the important role of gonadulin in regulating vitellogenesis and oocyte growth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jan A. Veenstra
Summary: The study investigated the electrocoagulation of four paraldehyde fuchsin positive cells in the brain of Locusta migratoria, which might produce a diuretic hormone similar to calcitonin. Calcitonin-A is produced by neurons and neuroendocrine cells, while calcitonin-B is expressed by numerous enteroendocrine cells in the midgut. The crossreactivity between antigens in rabbit antisera and neuroendocrine cells in the brain suggests a common C-terminal dipeptide shared between Locusta calcitonin-A, calcitonin-B and ACP.
Article
Infectious Diseases
Jessica Waldman, Marina Amaral Xavier, Larissa Rezende Vieira, Raquel Logullo, Gloria Regina Cardoso Braz, Lucas Tirloni, Jose Marcos C. Ribeiro, Jan A. Veenstra, Itabajara da Silva Vaz
Summary: This study investigates the synganglion, the central nervous system of ticks, and identifies numerous neuropeptides that play crucial roles in tick physiology. These neuropeptides have the potential to be targeted for drug development.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Endocrinology & Metabolism
Jan A. Veenstra
Summary: Among the nine genes related to insulin and insulin-like growth factor in the American cockroach, seven are expressed in the central nervous system. The cells in the pars intercerebralis show significant expression of five of these genes. Antisera testing confirms that these cells are neuroendocrine and project to the corpora cardiaca. In contrast to fruit flies, multiple cell types in cockroaches express different genes, indicating a more complex regulation by insulin and IGF-related peptides in cockroaches.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jan A. A. Veenstra
Summary: Termites live in colonies, with different members having specific roles. In higher termites, the queen is fed only saliva from workers and can live for many years and lay thousands of eggs daily. While the composition of honeybee royal jelly is known, the composition of worker termite saliva in higher termites is largely unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jan A. Veenstra
Summary: In some insect species, the same genome can result in different final forms, a phenomenon called polyphenism. The role of insulin-like peptides (ilps) in growth, reproduction, and polyphenism regulation in termites is largely unknown. This study identified several ilps in termites and proposed hypotheses regarding their functions.
Article
Cell Biology
Yingge Li, Xiaoya Zhou, Chen Cheng, Guangming Ding, Peng Zhao, Kai Tan, Lixia Chen, Norbert Perrimon, Jan A. Veenstra, Luoying Zhang, Wei Song
Summary: Severe sleep deprivation is associated with systemic energy wasting, and in this study, it was found that the gut-peptide hormone AstA plays an essential role in mediating this energy wasting. AstA promotes the release of the adipokinetic hormone Akh, which mobilizes systemic energy reserves. This regulation of energy metabolism by AstA was observed in both flies and mice, and the molecular mechanisms involved were also elucidated.
Article
Biochemistry & Molecular Biology
Francesca Sara Colizzi, Jan A. Veenstra, Gustavo L. Rezende, Charlotte Helfrich-Foerster, David Martinez-Torres
Summary: In this study, a PDF-coding gene that has undergone significant changes in an otherwise highly conserved insect was identified in the aphid species Acyrthosiphon pisum. The results suggest that PDF may play a critical role in aphid seasonal timing.
Article
Biochemical Research Methods
Huanchao Zeng, Yiru Qin, Erxia Du, Qiulan Wei, Ying Li, Danyan Huang, Guirong Wang, Jan A. Veenstra, Sheng Li, Na Li
Summary: Through an integrated approach of genomics and peptidomics, this study identified 35 conserved neuropeptides and a potential novel neuropeptide in the American cockroach. The research provides a comprehensive neuropeptidome and detailed spatiotemporal distribution patterns, laying a solid foundation for future functional studies of neuropeptides in this insect species.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)