Article
Infectious Diseases
Lingling Liu, Kehang Xie, Mengmeng Yin, Xiaoqiu Chen, Binhuan Chen, Jianting Ke, Cheng Wang
Summary: This study aimed to investigate the association between urinary tract infection (UTI) in adults and serum 25-hydroxyvitamin D (25OHD) levels. The study found that UTI patients had lower serum 25OHD levels, especially in women. Women with UTI had significantly lower 25OHD concentrations than those without UTI. No association between serum 25OHD levels and UTI was found in men. The multivariable logistic regression models showed significant associations between UTI and 25OHD, female sex, neutrophilic lymphocyte ratio and C-reactive protein.
Article
Multidisciplinary Sciences
Maham Babar, Maryam Fatima, Ahmad Nawaz, Muhammad Amjad Bashir, Wajahat Ali Khan, Shujaat Ali Khan, A. H. Sneharani, Jawahir Ahmad Mokhtar, Shaymaa Abdalal, Steve Harakeh, Muhammad Essa
Summary: The occurrence of vitamin D deficiency is higher in children with urinary tract infections.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Nutrition & Dietetics
Yan Gan, Siyi You, Junjie Ying, Dezhi Mu
Summary: This systematic review and meta-analysis found that children with urinary tract infection (UTI) have lower serum vitamin D levels compared to healthy controls. Low vitamin D levels are significantly associated with UTI in children, especially when the serum level is less than 20 ng/mL.
Review
Public, Environmental & Occupational Health
Xiaoyan Li, Qing Yu, Feng Qin, Biyu Zhang, Yanming Lu
Summary: This study found that serum vitamin D levels were significantly lower in children with urinary tract infections compared to healthy controls, indicating a significant negative relationship between serum vitamin D levels and the risk of urinary tract infections in children.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Biochemistry & Molecular Biology
Antonela Gverovic Antunica, Ljubo Znaor, Mira Ivankovic, Velibor Puzovic, Irena Markovic, Snjezana Kastelan
Summary: Diabetic retinopathy, the most common eye disease complication of diabetes, is associated with hypovitaminosis D. Vitamin D2 and D3 are the main forms of vitamin D, with sunlight being a major source. Vitamin D plays a crucial role not only in maintaining healthy bones and immune system but also in the development of various diseases, including diabetic retinopathy. Diagnosis of vitamin D deficiency, which is prevalent worldwide, is done through measuring serum concentration of 25-hydroxyvitamin D. Supplementation of vitamin D has been proven effective in treating diabetic retinopathy, but under the recommendation and supervision of a doctor to prevent potential negative side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Meital Elbaz, Amanda Chikly, Ronnie Meilik, Ronen Ben-Ami
Summary: The urinary tract is an uncommon source of Candida bloodstream infection (CBSI), but the frequency of U-CBSI may be increasing. Patients with U-CBSI are typically older with a higher incidence of dementia, and risk factors include bladder catheterization and urologic procedures. U-CBSI tends to occur earlier and have a lower mortality rate compared to CBSI of undetermined origin.
Review
Food Science & Technology
Peng Gao, Weijing Liang, Qian Zhao, Haimei Li, Lijia Guan, Dan Li
Summary: This study evaluated the effects of micronutrient supplementation on urinary tract infection (UTI) in children, and found that vitamin D and vitamin C supplementation can reduce the risk and duration of symptoms of UTI. However, the impact of zinc supplementation on UTI remains unclear. Further research is needed to establish the effects of micronutrients on the treatment outcomes of UTI.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2023)
Article
Medicine, General & Internal
Saba Qadir, Shazia Memon, Muhammad Nadeem Chohan, Yasmeen Memon
Summary: The study showed that children with vitamin D deficiency are more prone to urinary tract infections, with symptoms mainly presenting as fever, vomiting, abdominal pain, and dysuria. The frequency of vitamin D deficiency in children diagnosed with UTI was 45.93%, with moderate deficiency being more common.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Milosz Caban, Urszula Lewandowska
Summary: This article reviews the current knowledge on the link between vitamin D and its receptor and the occurrence of eye disease, as well as the influence of analogues of calcitriol, an active metabolite of vitamin D. It is found that patients with various ocular disorders generally have vitamin D deficiency, and vitamin D may modulate the course of eye diseases and serve as a marker. Supplementation of vitamin D could potentially alleviate some eye disorders, but further randomized trials are recommended to clarify the link and activity between vitamin D and eye disease.
Review
Oncology
Ioanna-Maria Gkotinakou, Ilias Mylonis, Andreas Tsakalof
Summary: Vitamin D functions as a nutrient as well as a hormone, regulating various physiological functions. The relationship between calcitriol and HIF signaling in cancer development and treatment needs further investigation.
Review
Public, Environmental & Occupational Health
N. Salari, Y. Khoshbakht, M. Hemmati, Y. Khodayari, A. A. Khaleghi, F. Jafari, S. Shohaimi, M. Mohammadi
Summary: The global prevalence of urinary tract infections (UTIs) in pregnant women was found to be 23.9% based on a systematic review and meta-analysis. The study also identified that an increase in sample size and study year was associated with a decrease in UTI prevalence in pregnant women.
Article
Nutrition & Dietetics
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Recent studies have suggested that vitamin D supplementation may reduce the severity of infections, but its effect on hospitalization for infection has not been confirmed. This study found that vitamin D supplementation had no effect on the incidence of hospitalization for any infection, but it reduced the number of extended hospitalizations lasting more than 6 days.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Urology & Nephrology
Penghui Yuan, Tao Wang, Hao Li, Ruzhu Lan, Mingchao Li, Jihong Liu
Summary: This study found that vitamin D insufficiency is associated with lower urinary tract symptoms and that vitamin D intake can reduce the risk of these symptoms, especially in non-Asians, females, and patients with urinary incontinence.
JOURNAL OF UROLOGY
(2021)
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Article
Immunology
Pilar Flores-Espinosa, Andrea Olmos-Ortiz, Martha Granados-Cepeda, Braulio Quesada-Reyna, Rodrigo Vega-Sanchez, Pilar Velazquez, Veronica Zaga-Clavellina
Summary: Prolactin plays a role in regulating the secretion of MMPs and TIMPs in human fetal membranes after LPS challenge, potentially maintaining the structural balance of the membranes.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Diana Trujillo-Benitez, Myrna Luna-Gutierrez, Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Clara Santos-Cuevas, Gerardo Bravo-Villegas, Enrique Morales-Avila, Pedro Cruz-Nova, Lorenza Diaz-Nieto, Janice Garcia-Quiroz, Erika Azorin-Vega, Antonio Rosato, Laura Melendez-Alafort
Summary: This research focused on designing, synthesizing, and preclinically evaluating a new FAP inhibitor radiopharmaceutical for SPECT imaging. The results showed high radiotracer stability, specific recognition for FAP, high tumor uptake, and fast kidney elimination.
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Rocio Garcia-Becerra, Alejandro Zentella-Dehesa, Fernando Larrea, Lorenza Diaz
Summary: The study found that in triple-negative breast cancer cell lines, calcitriol and curcumin partially inhibited the endothelial cell-induced process of vasculogenic mimicry (VM). Calcitriol promoted morphological changes in the cells, while curcumin reduced the 3D structure of VM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lorenza Diaz, Samantha V. Bernadez-Vallejo, Rafael Vargas-Castro, Euclides Avila, Karla A. Gomez-Ceja, Rocio Garcia-Becerra, Mariana Segovia-Mendoza, Heriberto Prado-Garcia, Galia Lara-Sotelo, Javier Camacho, Fernando Larrea, Janice Garcia-Quiroz
Summary: Cervical cancer, mainly caused by HPV infection, is the fourth most common cancer among women worldwide. This study found that alpha-mangostin (AM) inhibits cell proliferation, induces cell cycle arrest and cell death in different cervical cancer cell lines. AM also decreases the expression of HPV oncogenes (E6, E7) and KCNH1 gene, and inhibits tumor growth in mice. These findings suggest that AM could be a potential adjuvant for the treatment and prevention of cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rodrigo Jimenez-Escutia, Donovan Vargas-Alcantar, Pilar Flores-Espinosa, Addy Cecilia Helguera-Repetto, Oscar Villavicencio-Carrisoza, Ismael Mancilla-Herrera, Claudine Irles, Yessica Dorin Torres-Ramos, Maria Yolotzin Valdespino-Vazquez, Pilar Velazquez-Sanchez, Rodrigo Zamora-Escudero, Marcela Islas-Lopez, Caridad Carranco-Salinas, Lorenza Diaz, Veronica Zaga-Clavellina, Andrea Olmos-Ortiz
Summary: Placentas from gestational diabetes mellitus (GDM) patients undergo significant metabolic and immunologic adaptations due to hyperglycemia, resulting in an increased risk for infections. Insulin and metformin have anti-inflammatory effects and strengthen placental barrier defenses to reduce bacterial infections in a hyperglycemic environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Euclides Avila, Bryan Javier Noriega-Mejia, Jocelyn Gonzalez-Macias, Ulises Cortes-Hernandez, Janice Garcia-Quiroz, Rocio Garcia-Becerra, Lorenza Diaz
Summary: Vitamin D and the vitamin D endocrine system play a crucial role in regulating calcium homeostasis and have antitumoral effects in various human cancers, including cervical cancer. Studies have shown an inverse relationship between cervical neoplasia and vitamin D levels. This review supports the idea that the vitamin D endocrine system has a preventive role in cervical cancer, particularly in the early stages, by suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and potentially clearing HPV-dependent lesions. However, vitamin D seems to have little effectiveness in advanced cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Pilar Flores-Espinosa, Isabel Mendez, Claudine Irles, Andrea Olmos-Ortiz, Cecilia Helguera-Repetto, Ismael Mancilla-Herrera, Daniel Ortuno-Sahagun, Vincent Goffin, Veronica Zaga-Clavellina
Summary: The close interaction between fetal and maternal cells during pregnancy requires various immune-endocrine mechanisms to provide a tolerant environment for the fetus and protect it against infections. Prolactin (PRL), a hormone synthesized by the maternal decidua, is transported through the amnion-chorion and accumulates in the amniotic cavity, creating a hyperprolactinemic environment for the fetus. PRL has multiple immunomodulatory functions, but its precise role at the maternal-fetal interface is still not fully understood. This review summarizes the current knowledge on the immunological effects of PRL and its biological significance for the immune privilege of the maternal-fetal interface.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Maria J. Ibarra-Sanchez, Jose Esparza-Lopez, Rocio Garcia-Becerra, Fernando Larrea, Lorenza Diaz
Summary: This study investigates the role of endothelial cells in vasculogenic mimicry (VM) in triple-negative breast cancer (TNBC) and the involvement of the FGFR/PI3K/Akt pathway. Results show that endothelial cells play a predominant role in inducing VM, and the FGFR/PI3K/Akt pathway is implicated in this process. Targeting this pathway may hold promise for treating and preventing VM in TNBC tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
