Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Mengdi Qu, Hao Zhang, Zhaoyuan Chen, Xingfeng Sun, Shuainan Zhu, Ke Nan, Wankun Chen, Changhong Miao
Summary: ?Ferroptosis is a newly discovered type of regulated cell death characterized by iron-dependent lipid peroxidation. It is involved in the pathological development of various diseases and recent studies suggest its potential as a therapeutic target for acute lung injury/acute respiratory distress syndrome.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ser Hon Puah, Barnaby Edward Young, Po Ying Chia, Vui Kian Ho, Jiashen Loh, Roshni Sadashiv Gokhale, Seow Yen Tan, Duu Wen Sewa, Shirin Kalimuddin, Chee Keat Tan, Surinder K. M. S. Pada, Matthew Edward Cove, Louis Yi Ann Chai, Purnima Parthasarathy, Benjamin Choon Heng Ho, Jensen Jiansheng Ng, Li Min Ling, John A. Abisheganaden, Vernon J. M. Lee, Cher Heng Tan, Raymond T. P. Lin, Yee Sin Leo, David C. Lye, Tsin Wen Yeo
Summary: This study aimed to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. The results showed that ventilated patients were older, had more dyspnea, and higher levels of inflammatory markers, but there were no fatalities among COVID-19 patients who required mechanical ventilation in Singapore.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Arne Peine, Ahmed Hallawa, Johannes Bickenbach, Guido Dartmann, Lejla Begic Fazlic, Anke Schmeink, Gerd Ascheid, Christoph Thiemermann, Andreas Schuppert, Ryan Kindle, Leo Celi, Gernot Marx, Lukas Martin
Summary: The VentAI reinforcement learning algorithm provides reproducible high performance by dynamically suggesting an optimized, individualized ventilation strategy for critically ill patients. Compared to standard clinical care by physicians, VentAI significantly increased performance returns and recommended actions more frequently with specific settings for PEEP, FiO(2), and tidal volume. VentAI's preference for lower tidal volumes, certain PEEP levels, and avoiding high FiO(2) values could potentially benefit critically ill patients.
NPJ DIGITAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Camilla Margaroli, Timothy Fram, Nirmal S. Sharma, Siddharth B. Patel, Jennifer Tipper, Sarah W. Robison, Derek W. Russell, Seth D. Fortmann, Mudassir M. Banday, Yixel Soto-Vazquez, Tarek Abdalla, Sawanan Saitornuang, Matthew C. Madison, Sixto M. Leal Jr, Kevin S. Harrod, Nathaniel B. Erdmann, Amit Gaggar
Summary: Neutrophilic inflammation is observed in respiratory viral infections, including COVID-19-related acute respiratory distress syndrome, but its role in disease pathogenesis is unclear. This study phenotyped immune cells in the blood and airway of 52 severe COVID-19 patients and identified two subpopulations of neutrophils. The loss of one neutrophil subset correlated with increased viral burden and decreased survival. Further experiments showed that this subset exhibited an antiviral response, which was dependent on type I interferon signaling. Understanding this neutrophil phenotype could lead to new therapeutic approaches for viral illnesses.
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Biochemistry & Molecular Biology
Li-Chung Chiu, Hsiang-Yu Tang, Chun-Ming Fan, Chi-Jen Lo, Han-Chung Hu, Kuo-Chin Kao, Mei-Ling Cheng
Summary: Acute respiratory distress syndrome (ARDS) is characterized by dysregulated immune-inflammatory responses and high mortality. This study found that the activation of the kynurenine pathway, a metabolic pathway, is associated with mortality in ARDS patients. Plasma kynurenine levels and the kynurenine/tryptophan ratio were higher in non-survivors compared to survivors. Urine metabolic profiling also revealed higher tryptophan degradation in non-survivors. These findings suggest that the kynurenine pathway could serve as a prognostic marker and a target for therapeutic interventions in ARDS.
Review
Medicine, General & Internal
Chiara Robba, Denise Battaglini, Lorenzo Ball, Alberto Valbusa, Italo Porto, Roberta Della Bona, Giovanni La Malfa, Nicolo Patroniti, Iole Brunetti, Maurizio Loconte, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Claudia Lucia M. Silva, Patricia R. M. Rocco, Paolo Pelosi
Summary: In critically ill patients with ARDS-related COVID-19, there is a high incidence of thromboembolic and hemorrhagic events due to impaired balance in platelet function and coagulation and fibrinolysis regulatory mechanisms. The pathophysiology involves tissue factor pathway activation after an inflammatory trigger, leading to massive infiltration of activated platelets, along with a variety of clinical presentations. Tailored treatment focusing on bleeding and thrombosis risk estimation is recommended, with advanced laboratory tests being useful for diagnosis and management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Nadir Yehya, Hossein Fazelinia, Gladys G. Lawrence, Lynn A. Spruce, Mark Mai, G. Scott Worthen, Jason D. Christie
Summary: This study found that plasma nucleosomes are associated with the severity of acute respiratory distress syndrome (ARDS) in children, as well as with nonpulmonary organ failures. Nucleosomes were also linked to higher mortality rates and fewer ventilator-free days in the pediatric ARDS patients. Proteomic analysis further showed elevated levels of core nucleosome histones in septic children with ARDS.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Alexander C. Reisinger, Tobias Niedrist, Florian Posch, Stefan Hatzl, Gerald Hackl, Juergen Prattes, Gernot Schilcher, Anna-Maria Meissl, Reinhard B. Raggam, Markus Herrmann, Philipp Eller
Summary: Soluble urokinase plasminogen activator receptor (suPAR) levels at ICU admission are associated with ICU and 28-day mortality, as well as SOFA score, coagulation and inflammation markers, and AKI-3 occurrence. suPAR may offer additional value for risk stratification, especially in ICU patients with moderate organ dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Mohamed Shawky Elfarargy, Ghada M. Al-Ashmawy, Sally Abu-Risha, Haidy Khattab
Summary: Zinc supplementation shows significant improvement in clinical and laboratory indicators for neonatal RDS, leading to reduced hospitalization duration and decreased need for mechanical ventilation.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Ophthalmology
Timothy J. Patterson, Peter Currie, Michael Williams, Claire Shevlin
Summary: The purpose of this study was to investigate ocular injuries in critical care patients in prone versus supine positions during the COVID-19 pandemic. The results showed no significant difference in the rate of reported ocular injury between the two groups, but further studies are needed for confirmation.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, Research & Experimental
Qianqian Li, Rui Li, Hanlin Yin, Suli Wang, Bei Liu, Jun Li, Mi Zhou, Qingran Yan, Liangjing Lu
Summary: This study evaluated the potential of IRAK4 inhibitors as a treatment for ARDS-cytokine release syndrome (CRS). The results showed that BAY-1834845 effectively prevented lung injury and improved existing ARDS when combined with dexamethasone. Compared to other drugs, BAY-1834845 reduced inflammatory cell infiltration and neutrophil count. Interestingly, BAY-1834845 preserved the signatures of naive lymphocytes and stromal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Review
Anesthesiology
Tobias Schlesinger, Stephanie Weibel, Peter Kranke
Summary: Purpose of this review is to address postoperative/postdischarge nausea and vomiting (PONV/PDNV) issues in perioperative care, especially in outpatient surgery. The evidence on prophylaxis and treatment of PONV is increasing, but implementation is still poor. Progress has been made in endorsing a liberal, universal PONV management, but specific evidence for preventing and treating PDNV is still limited.
CURRENT OPINION IN ANESTHESIOLOGY
(2023)
Review
Anesthesiology
Tobias Schlesinger, Patrick Meybohm, Peter Kranke
Summary: Postoperative/postdischarge nausea and vomiting (PONV/PDNV) are still important issues in perioperative care. In ambulatory surgery, PONV can hinder discharge or lead to readmission. The evidence for managing PONV is good but implementation is lacking, and a universal, multimodal approach for PONV prophylaxis is recommended. Evidence on PDNV is insufficient, and its management is primarily based on PONV prophylaxis and therapy.
CURRENT OPINION IN ANESTHESIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Eerde H. Weening, Ali A. Al-Mubarak, Kevin Damman, Adriaan A. Voors, Dirk J. van Veldhuisen, Hiddo J. L. Heerspink, Lutz Schomburg, Peter van Der Meer, Nils Bomer
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Oliver J. Liakopoulos, Elmar W. Kuhn, Martin Hellmich, Markus Schloemicher, Justus Strauch, Wilko Reents, Anno Diegeler, Matthias Thielmann, Daniel Wendt, Jochen Boergermann, Jan F. Gummert, Christian Stoppe, Andreas Goetzenich, Sven Martens, Hermann Reichenspurner, Jens Wippermann, Hannes Reuter, Yeong-Hoon Choi, Thorsten Wahlers
Summary: This study aimed to analyze the effects of high-dose statin therapy before surgical revascularization. The results showed that additional statin loading before surgery did not reduce the rate of major adverse cardiac and cerebrovascular events (MACCE) occurring within 30 days.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Nawwar Al-Attar, Jullien Gaer, Vincenzo Giordano, Emma Harris, Alan Kirk, Mahmoud Loubani, Patrick Meybohm, Rana Sayeed, Ulrich Stock, Jennifer Travers, Becky Whiteman
Summary: The COVID-19 pandemic has had a significant impact on surgical specialties and the UK National Health Service. Surgeons in the UK have faced challenges in treating high-risk, urgent patients who cannot wait for prehabilitation. The pandemic has also affected blood transfusion due to uncertain demand patterns, reduced donations, and loss of staff. In response to these challenges, an expert Task Force reviewed the impact of bleeding in cardiothoracic surgery and proposed best practice recommendations in the UK, focusing on the use of haemostats.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Nutrition & Dietetics
Christian Stoppe, Ellen Dresen, Sebastian Wendt, Gunnar Elke, Jayshil J. Patel, Liam McKeever, Michael Chourdakis, Bernard McDonald, Patrick Meybohm, Matthias Lindner, Rakesh C. Arora, Ben O'Brien, Vera von Dossow, Sergey Efremov, Vladimir Lomivorotov, Charlene Compher, Jill Yaung, Taryne Imai, Michael Nurok, Andrea Ho, Christian von Loeffelholz, Foong Pui Hing, Xuran Jiang, Daren K. Heyland
Summary: A study was conducted to describe the current nutrition practices in critically ill cardiac surgery patients worldwide. The study found that patients had significant delays in starting enteral nutrition and received low levels of energy and protein. There was also tremendous variability in site performance. However, achieving optimal nutrition performance is feasible.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Jayshil J. Patel, Todd W. Rice, Manpreet S. Mundi, Christian Stoppe, Stephen A. McClave
Summary: The NUTRIREA-2 and NUTRIREA-3 trials compared nutrition routes and doses in critically ill patients with circulatory shock. The results of both trials support a paradigm shift towards less-is-more in the early acute phase of critical illness. This review outlines the results of the trials, introduces the concept of identifying the optimal nutrition dose based on illness severity/risk and nutrition dose, and highlights the unintended consequences of providing full-dose nutrition to sicker critically ill patients during the early acute phase.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Ellen Dresen, Quirin Notz, Johannes Menger, Anna L. Homayr, Matthias Lindner, David I. Radke, Christian Stoppe, Gunnar Elke
Summary: Medical nutrition therapy (MNT) is crucial for critically ill patients in the ICU. The optimal timing, dosing, and composition of energy and nutrient supply, as well as the role of micronutrients, are still debated topics due to heterogeneity in research findings. Implementing personalized MNT strategies in clinical practice poses challenges. This review aims to summarize recent evidence and provide guidance for evidence-based approaches to nutrient supply in the ICU.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Maria Schwarz, Caroline E. Meyer, Alina Loeser, Kristina Lossow, Julian Hackler, Christiane Ott, Susanne Jaeger, Isabelle Mohr, Ella A. Eklund, Angana A. H. Patel, Nadia Gul, Samantha Alvarez, Ilayda Altinonder, Clotilde Wiel, Maria Maares, Hajo Haase, Anetta Haertlova, Tilman Grune, Matthias B. Schulze, Tanja Schwerdtle, Uta Merle, Hans Zischka, Volkan I. Sayin, Lutz Schomburg, Anna P. Kipp
Summary: Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P and its transport from the liver, while copper levels affect the release and transport of selenoprotein P, potentially impacting selenium transport to peripheral organs.
NATURE COMMUNICATIONS
(2023)
Article
Anesthesiology
Ida Doehler, Daniel Roeder, Tobias Schlesinger, Christian Alexander Nassen, Christoph-Thomas Germer, Armin Wiegering, Johan Friso Lock
Summary: This study suggests that an individual risk-adjusted bridging regimen may reduce postoperative bleeding events while still protecting against thromboembolic events.
BMC ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
David Henckert, Amos Malorgio, Giovanna Schweiger, Florian J. Raimann, Florian Piekarski, Kai Zacharowski, Sebastian Hottenrott, Patrick Meybohm, David W. Tscholl, Donat R. Spahn, Tadzio R. Roche
Summary: Artificial intelligence (AI) is predicted to have a significant impact on perioperative medicine, but little is known about anesthesiologists' knowledge and perceptions of AI in this context. To address this, we conducted face-to-face interviews with 21 anesthesiologists and surveyed 70 anesthesiologists to assess their views on AI. The interviews revealed good knowledge of AI basics but limited awareness of its potential applications in anesthesia. The survey confirmed a generally positive attitude towards AI among the anesthesiologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Anna Dera-Szymanowska, Dorota Filipowicz, Natalia Misan, Krzysztof Szymanowski, Thilo Samson Chillon, Sabrina Asaad, Qian Sun, Ewelina Szczepanek-Parulska, Lutz Schomburg, Marek Ruchala
Summary: This study aims to compare iron and calcium levels in singleton and twin pregnancies, and found no significant differences between the two. Prenatal iron supplementation was shown to effectively increase iron levels.
Article
Multidisciplinary Sciences
Maria Maares, Alessia Haupt, Christoph Schuessler, Marcel Kulike-Koczula, Julian Hackler, Claudia Keil, Isabelle Mohr, Lutz Schomburg, Roderich D. Suessmuth, Hans Zischka, Uta Merle, Hajo Haase
Summary: This study introduces a fluorometric high throughput assay using the novel Cu2+ binding fluoresceine-peptide sensor FP4 to determine labile Cu2+ in human and rat serum. The labile Cu2+ concentration in human serum was found to be 0.14±0.05 pM, showing no correlation with age or other serum trace elements. The analysis of patients with Wilson's disease showed a significant decrease in labile Cu2+ following copper chelation therapy, suggesting its potential as a specific marker for disease status and treatment progress monitoring.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Amos Malorgio, David Henckert, Giovanna Schweiger, Julia Braun, Kai Zacharowski, Florian J. Raimann, Florian Piekarski, Patrick Meybohm, Sebastian Hottenrott, Corinna Froehlich, Donat R. Spahn, Christoph B. Noethiger, David W. Tscholl, Tadzio R. Roche
Summary: This study aimed to integrate machine learning models for vital sign predictions into the Philips Visual-Patient-avatar for easy use by human caregivers. The visualizations of prediction were validated and showed a high accuracy of identification for conditions, although the accuracy decreased when considering urgencies. User feedback from standardized interviews and an online survey indicated that the prediction visualizations were fun to use but identifying the urgencies was challenging.
Article
Medicine, General & Internal
Greta Gasciauskaite, Justyna Lunkiewicz, Giovanna Schweiger, Alexandra D. Budowski, David Henckert, Tadzio R. Roche, Lisa Bergauer, Patrick Meybohm, Sebastian Hottenrott, Kai Zacharowski, Florian Juergen Raimann, Eva Rivas, Manuel Lopez-Baamonde, Michael Thomas Ganter, Tanja Schmidt, Christoph B. Noethiger, David W. Tscholl, Samira Akbas
Summary: Blood gas analysis is crucial in modern medicine, and the interpretation of its results can be complex. Visual Blood, a novel visualization technique, offers a user-centered solution to reduce the cognitive load associated with interpreting blood gas analysis. An international, multicenter study found that anesthesiologists found Visual Blood to be an intuitive and easy-to-learn method, although adjustments are needed to reduce visual overload.