Article
Biology
Xiaopang Ren, Wanjiao Hao, Jin Liu, Ye Li, Bing Wang, Xinhui Zu, Hulling Xue
Summary: TRPV2 and MMP-2 play important roles in ovarian cancer, and their expressions are closely associated with the occurrence and development of ovarian cancer. The study found significantly increased expressions of TRPV2 and MMP-2 in ovarian cancer tissues, and their expressions were closely related to tumor stage, differentiation, and lymph node metastasis.
Article
Cell Biology
Chia-Lung Tsai, Shih-Ming Jung, Lang-Ming Chi, Chi-Neu Tsai, Chiao-Yun Lin, Angel Chao, Yun-Shien Lee
Summary: This study demonstrated that GSK3β forms a complex with ETS1 and promotes the stability of ETS1 and induces the transcriptional activation of MMP-9 and cell migration through phosphorylation at threonine 265 and serine 269. The GSK3β/ETS1/MMP-9 axis may regulate the biological aggressiveness of ovarian cancer and serve as a prognostic factor in patients with this malignancy.
Article
Multidisciplinary Sciences
Parash Prasad, Sib Sankar Roy
Summary: This study demonstrates that glutamine deprivation reduces migration and invasion properties of ovarian cancer cells by regulating ETS1 and inducing EMT. ETS1 expression and nuclear localization upon glutamine starvation are controlled in a cell type-specific manner.
Article
Oncology
Magdalena Chrabanska, Magdalena Rynkiewicz, Pawel Kiczmer, Bogna Drozdzowska
Summary: CD44, MMP-2, and MMP-9 are potential molecular prognostic markers in renal cell carcinoma (RCC). The expression of CD44, MMP-2, and MMP-9 in association with the histopathological subtype of RCC affects the survival of patients with renal cancer. CD44 expression and the histopathological subtype of clear-cell RCC are independent risk factors for patient death.
Review
Cell Biology
Elizabeth T. Evans, Ben Horst, Rebecca C. Arend, Karthikeyan Mythreye
Summary: Activins and inhibins are members of the TGF8 family of growth factors, with diverse effects in various physiological and pathological processes. They play important roles in angiogenesis, immunity, and potentially tumorigenesis. This review focuses on the biological role, signaling mechanisms, and implications of activins and inhibins in ovarian cancers.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Oncology
Krzysztof Ksiazek
Summary: This review discusses various aspects of cellular senescence associated with intraperitoneal ovarian cancer metastasis, including mechanisms of senescence in normal peritoneal mesothelial cells, the role of senescent mesothelium in ovarian cancer progression, the effect of drugs commonly used as first-line therapy in ovarian cancer patients on senescence of normal cells, mechanisms of spontaneous senescence in ovarian cancer cells, and other pharmacologic strategies to induce senescence in ovarian malignancies.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Cristina Mitric, Lina Salman, Lusine Abrahamyan, Soyoun Rachel Kim, Petros Pechlivanoglou, Kelvin K. W. Chan, Lilian T. Gien, Sarah E. Ferguson
Summary: The study investigates the prevalence of mismatch repair protein deficiency (MMRd), microsatellite instability (MSI), and Lynch syndrome (LS) in epithelial ovarian cancer (EOC) and their diagnostic accuracy. It also examines the prevalence of MMRd, MSI-high, and LS in synchronous ovarian endometrial cancer and in histological subtypes.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
Amit Atwal, Tristan Snowsill, Marcus Cabrera Dandy, Thomas Krum, Claire Newton, Dafydd Gareth Evans, Emma J. Crosbie, Neil A. J. Ryan
Summary: Ovarian cancer has low survival rates and is often diagnosed late. Checkpoint inhibitors have shown potential as a treatment for ovarian cancer, but their use is limited by the lack of data on the prevalence of mismatch repair deficiency. This study conducted a systematic review and meta-analysis to estimate the prevalence of mismatch repair deficiency in ovarian cancer. The results showed that a significant minority of ovarian cancer cases display mismatch repair deficiency and could potentially benefit from checkpoint inhibition therapy. However, further high-quality studies are needed to explore the use of multimodal testing and the efficacy of checkpoint inhibitors in mismatch repair deficient ovarian cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Elliot Lopez, Sahil Kamboj, Changchong Chen, Zixu Wang, Sabrina Kellouche, Johanne Leroy-Dudal, Franck Carreiras, Ambroise Lambert, Carole Aime
Summary: Ovarian cancer is a serious disease with a low survival rate, mainly due to late diagnosis and metastasis. Understanding the pathophysiology and developing relevant in vitro models are crucial for effective drug screening. Recent advances in 3D cell culture and microfluidics provide innovative models to bridge the gap between pathophysiology and clinical research.
Article
Oncology
Robert L. Hollis, Ian Croy, Michael Churchman, Clare Bartos, Tzyvia Rye, Charlie Gourley, C. Simon Herrington
Summary: Ovarian carcinosarcoma is a rare and highly aggressive type of ovarian cancer that requires new treatment strategies urgently. Histological subclassification does not identify patient subgroups with distinct survival.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Analytical
D. Vieira, J. Barralet, E. J. Harvey, G. Merle
Summary: This study presents a new approach to enhance the electrochemical interaction of MMP-14 with the electrode surface using a specific commercial molecule called NSC-405020. By grafting NSC-405020 onto carbon nanotubes, MMP-14 can be detected and quantified with a wide linear detection range and low detection limit.
Article
Oncology
Barbara Alves, Joana Peixoto, Sofia Macedo, Jorge Pinheiro, Bruno Carvalho, Paula Soares, Jorge Lima, Raquel T. Lima
Summary: This study evaluated the expression of MMP-2, MMP-9, YKL40, and VEGFA in a series of glioblastoma (GB) and their impact on patient outcome. High levels of VEGFA expression were significantly associated with improved progression-free survival after bevacizumab treatment, thus having potential as a tissue biomarker for predicting patients' response to bevacizumab. To a lesser extent, YKL40 also provided significant information regarding the extent of bevacizumab treatment. This study highlights the importance of studying secretome-associated proteins as GB biomarkers and identifies VEGFA as a promising marker for predicting response to bevacizumab.
Review
Biochemistry & Molecular Biology
Ghofraan Abdulsalam Atallah, Nirmala Chandralega Kampan, Kah Teik Chew, Norfilza Mohd Mokhtar, Reena Rahayu Md Zin, Mohamad Nasir bin Shafiee, Nor Haslinda binti Abd. Aziz
Summary: Ovarian cancer is a deadly reproductive tumor affecting women worldwide. Chemoresistance and the need for biomarkers to predict platinum resistance in order to improve survival and quality of life are important factors in the treatment of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Shirley Mei, David Chelmow, Kimberly Gecsi, Joel Barkley, Emily Barrows, Rebecca Brooks, Kathryn Huber-Keener, Myrlene Jeudy, Julia Sage O'Hara, William Burke
Summary: Health disparity, which refers to preventable differences in disease burden and health opportunities among socially disadvantaged populations, is prevalent in ovarian cancer outcomes. Factors such as race, ethnicity, insurance, socioeconomic status, and geographic location contribute to disparities in survival, treatment, and stage at diagnosis. Limited evidence suggests that adherence to treatment guidelines can help mitigate these disparities.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Oncology
Ze Wu, Qiongqiong Jia, Boqun Liu, Lanlan Fang, Peter C. K. Leung, Jung-Chien Cheng
Summary: This study reveals that upregulation of NPFFR2 is associated with poor overall survival in epithelial ovarian cancer (EOC). NPFF and NPFFR2 are expressed in human EOC cells, with higher levels in SKOV3 cells compared to CaOV3 and OVCAR3 cells. NPFF treatment stimulates cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway. Blocking ERK1/2 signaling abolishes the NPFF-induced MMP-9 expression and cell invasion.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Oncology
Belle H. de Rooij, Nicole P. M. Ezendam, Kim A. H. Nicolaije, M. Caroline Vos, Johanna M. A. Pijnenborg, Dorry Boll, Roy F. P. M. Kruitwagen, Lonneke V. van de Poll-Franse
JOURNAL OF CANCER SURVIVORSHIP
(2017)
Article
Oncology
Roelien van de Vrie, Hannah S. van Meurs, Marianne J. Rutten, Christiana A. Naaktgeboren, Brent C. Opmeer, Katja N. Gaarenstroom, Toon van Gorp, Henk G. Ter Brugge, Ward Hofhuis, Henk W. R. Schreuder, Henriette J. G. Arts, Petra L. M. Zusterzeel, Johanna M. A. Pijnenborg, Maarten van Haaften, Mirjam J. A. Engelen, Erik A. Boss, M. Caroline Vos, Kees G. Gerestein, Eltjo M. J. Schutter, Gemma G. Kenter, Patrick M. M. Bossuyt, Ben Willem Mol, Marrije R. Buist
GYNECOLOGIC ONCOLOGY
(2017)
Article
Oncology
Marlou E. C. L. van Broekhoven, Belle H. de Rooij, Johanna M. A. Pijnenborg, M. Caroline Vos, Dorry Boll, Roy F. P. M. Kruitwagen, Lonneke V. van de Poll-Franse, Nicole P. M. Ezendam
GYNECOLOGIC ONCOLOGY
(2017)
Article
Health Care Sciences & Services
Marline G. Harmsen, Miranda P. Steenbeek, Nicoline Hoogerbrugge, Helena C. van Doorn, Katja N. Gaarenstroom, M. Caroline Vos, Leon F. A. G. Massuger, Joanne A. de Hullu, Rosella P. . M. G. Hermens
HEALTH EXPECTATIONS
(2018)
Article
Oncology
Marianne J. Rutten, Hannah S. van Meurs, Roelien van de Vrie, Katja N. Gaarenstroom, Christiana A. Naaktgeboren, Toon van Gorp, Henk G. Ter Brugge, Ward Hofhuis, Henk W. R. Schreuder, Henriette J. G. Arts, Petra L. M. Zusterzeel, Johanna M. A. Pijnenborg, Maarten van Haaften, Guus Fons, Mirjam J. A. Engelen, Erik A. Boss, M. Caroline Vos, Kees G. Gerestein, Eltjo M. J. Schutter, Brent C. Opmeer, Anje M. Spijkerboer, Patrick M. M. Bossuyt, Ben Willem Mol, Gemma G. Kenter, Marrije R. Buist
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Belle H. de Rooij, Habibe Ikiz, Dorry Boll, Johanna M. A. Pijnenborg, Brenda M. Pijlman, Roy F. P. M. Kruitwagen, Lonneke V. van de Poll-Franse, M. Caroline Vos, Nicole P. M. Ezendam
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Article
Geriatrics & Gerontology
L. A. M. Van Lieshout, B. Pijlman, M. C. Vos, M. J. M. de Groot, S. Houterman, S. F. P. J. Coppus, M. G. Harmsen, I. Vandenput, J. M. J. Piek
Article
Oncology
Mark J. A. Rietveld, Olga Husson, M. C. (Caroline) Vos, Lonneke V. van de Poll-Franse, P. B. ( Nelleke) Ottevanger, Nicole P. M. Ezendam
Article
Health Care Sciences & Services
Belle H. de Rooij, Nicole P. M. Ezendam, Kim A. H. Nicolaije, Paul Lodder, M. Caroline Vos, Johanna M. A. Pijnenborg, Dorry Boll, Roy F. P. M. Kruitwagen, Lonneke V. van de Poll-Franse
QUALITY OF LIFE RESEARCH
(2018)
Article
Medicine, Research & Experimental
Nicole P. M. Ezendam, Belle H. de Rooij, Roy F. P. M. Kruitwagen, Carien L. Creutzberg, Ingrid van Loon, Dorry Boll, M. Caroline Vos, Lonneke V. van de Poll-Franse
Article
Oncology
Mies C. H. J. van Eenbergen, Ruben D. Vromans, Dorry Boll, Paul J. M. Kul, Caroline M. Vos, Emiel J. Krahmer, Floortje Mols, Lonneke van de Poll-Franse
Article
Oncology
Marike S. Lombaers, Karlijn M. C. Cornel, Nicole C. M. Visser, Johan Bulten, Heidi V. N. Kuesters-Vandevelde, Frederic Amant, Dorry Boll, Peter Bronsert, Eva Colas, Peggy M. A. J. Geomini, Antonio Gil-Moreno, Dennis van Hamont, Jutta Huvila, Camilla A. Krakstad, Arjan A. Kraayenbrink, Martin Koskas, Gemma Mancebo, Xavier Matias-Guiu, Huy M. Ngo, Brenda M. Pijlman, Maria Caroline Vos, Vit Weinberger, Marc P. L. M. W. Snijders, Sebastiaan W. S. van Koeverden, Ingfrid S. Haldorsen, Casper Reijnen, Johanna M. A. Pijnenborg
Summary: Patients with high-grade uterine cancer have a higher risk of cancer spreading to the lymph nodes compared to patients with low-grade uterine cancer. CA125, a marker detectable in blood, is associated with increased tumor spread. This study aimed to assess the predictive value of CA125 for uterine cancer spread and survival and the additional value of CT scan in high-grade uterine cancer. The findings showed that elevated CA125 was associated with advanced stage, lymph node metastasis, and a worse prognosis in high-grade uterine cancer.
Article
Primary Health Care
Natasja S. Delfstra, Annemarie A. Uijen, M. Caroline Vos, Reinier Akkermans, Antoine L. Lagro-Janssen, Doreth A. M. Teunissen
Summary: This study aims to identify factors associated with bacterial vaginosis (BV) recurrence and describe the characteristics and interventions of these patients by general practitioners (GPs). Patients with recent antibiotic prescriptions, a history of sexually transmitted infections and/or Candidiasis, and remote consultations were more likely to have recurrent BV. Microbiological tests were frequently performed in recurrent BV patients, and oral metronidazole was the most common prescription for both groups.
Article
Oncology
Casper Reijnen, Nicole C. M. Visser, Jenneke C. Kasius, Dorry Boll, Peggy M. Geomini, Huy Ngo, Dennis van Hamont, Brenda M. Pijiman, Maria Caroline Vos, Johan Bulten, Marc P. L. M. Snijders, Leon F. A. G. Massuger, Johanna M. A. Pijnenborg
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
