标题
The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-09-13
DOI
10.1038/s41467-021-25478-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
- (2021) Allison J. Greaney et al. Cell Host & Microbe
- Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein
- (2021) Houriiyah Tegally et al. NATURE
- Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
- (2021) Pengfei Wang et al. NATURE
- Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications
- (2021) Jasdeep Singh et al. Viruses-Basel
- Antibody evasion by the P.1 strain of SARS-CoV-2
- (2021) Wanwisa Dejnirattisai et al. CELL
- Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide
- (2021) Eileen Socher et al. Biomedicines
- SARS‐CoV‐2 B.1.617 Indian variants: Are electrostatic potential changes responsible for a higher transmission rate?
- (2021) Stefano Pascarella et al. JOURNAL OF MEDICAL VIROLOGY
- V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
- (2021) Junxian Ou et al. JOURNAL OF VIROLOGY
- COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence
- (2021) Felipe Gomes Naveca et al. NATURE MEDICINE
- Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
- (2021) Jamie Lopez Bernal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
- (2020) Haibo Zhang et al. INTENSIVE CARE MEDICINE
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
- (2020) Xiaolong Tian et al. Emerging Microbes & Infections
- Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
- (2020) Canrong Wu et al. Acta Pharmaceutica Sinica B
- Potential Therapeutic Targets and Promising Drugs for Combating SARS‐CoV‐2
- (2020) Hong Zhou et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
- (2020) Qihui Wang et al. CELL
- Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
- (2020) Alba Grifoni et al. CELL
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies
- (2020) Chunyan Yi et al. Cellular & Molecular Immunology
- Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atoms Simulations
- (2020) Angelo Spinello et al. Journal of Physical Chemistry Letters
- Comparing the Binding Interactions in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV
- (2020) Muhamed Amin et al. Journal of Physical Chemistry Letters
- Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
- (2020) Jun Lan et al. NATURE
- Site-specific glycan analysis of the SARS-CoV-2 spike
- (2020) Yasunori Watanabe et al. SCIENCE
- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
- (2020) Meng Yuan et al. SCIENCE
- SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions
- (2020) Mohammed Uddin et al. Viruses-Basel
- Enhanced Binding of SARS-CoV-2 Spike Protein to Receptor by Distal Polybasic Cleavage Sites
- (2020) Baofu Qiao et al. ACS Nano
- Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
- (2020) Tyler N. Starr et al. CELL
- Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
- (2020) Jiandong Huo et al. Cell Host & Microbe
- Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroids
- (2020) Amene Saghazadeh et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike
- (2020) Susmita Roy et al. Journal of Physical Chemistry Letters
- SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
- (2020) Giovanni Salvatori et al. Journal of Translational Medicine
- A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
- (2020) Jingyun Yang et al. NATURE
- Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
- (2020) Lihong Liu et al. NATURE
- Controlling the SARS-CoV-2 spike glycoprotein conformation
- (2020) Rory Henderson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions
- (2020) Yingjie Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
- (2020) Xiangyang Chi et al. SCIENCE
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
- (2020) Ching-Lin Hsieh et al. SCIENCE
- Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Complex
- (2020) Erik Laurini et al. ACS Nano
- COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials
- (2020) Rohan Chakraborty et al. BIOCHEMICAL PHARMACOLOGY
- Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
- (2020) Leonid Yurkovetskiy et al. CELL
- Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes
- (2020) Calvin S. Carter et al. Cell Metabolism
- Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
- (2020) Donald J. Benton et al. NATURE
- Spike mutation D614G alters SARS-CoV-2 fitness
- (2020) Jessica A. Plante et al. NATURE
- Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein
- (2020) Christine Toelzer et al. SCIENCE
- A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
- (2020) Angkana T. Huang et al. Nature Communications
- Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms
- (2020) Amanat Ali et al. Scientific Reports
- Is Cross-Reactive Immunity Triggering COVID-19 Immunopathogenesis?
- (2020) Alberto Beretta et al. Frontiers in Immunology
- Computational Insights into the Conformational Accessibility and Binding Strength of SARS-CoV-2 Spike Protein to Human Angiotensin-Converting Enzyme 2
- (2020) Cheng Peng et al. Journal of Physical Chemistry Letters
- Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
- (2020) Saptarshi Basu et al. PHYSICS OF FLUIDS
- Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells
- (2020) Scientific Reports
- Covid-19: New coronavirus variant is identified in UK
- (2020) Jacqui Wise BMJ-British Medical Journal
- Effects of an Electric Field on the Conformational Transition of the Protein: A Molecular Dynamics Simulation Study
- (2019) Zhouting Jiang et al. Polymers
- Nanosecond pulsed electric signals can affect electrostatic environment of proteins below the threshold of conformational effects: The case study of SOD1 with a molecular simulation study
- (2019) Elena della Valle et al. PLoS One
- Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
- (2018) Wenfei Song et al. PLoS Pathogens
- Efficient Construction of Free Energy Profiles of Breathing Metal–Organic Frameworks Using Advanced Molecular Dynamics Simulations
- (2017) Ruben Demuynck et al. Journal of Chemical Theory and Computation
- Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion
- (2017) Alexandra C. Walls et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Electric-field-stimulated protein mechanics
- (2016) Doeke R. Hekstra et al. NATURE
- Effect of Strong Electric Field on the Conformational Integrity of Insulin
- (2014) Xianwei Wang et al. JOURNAL OF PHYSICAL CHEMISTRY A
- Biomolecular structure manipulation using tailored electromagnetic radiation: a proof of concept on a simplified model of the active site of bacterial DNA topoisomerase
- (2014) Daungruthai Jarukanont et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- pyDockWEB: a web server for rigid-body protein–protein docking using electrostatics and desolvation scoring
- (2013) Brian Jiménez-García et al. BIOINFORMATICS
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- Polarizable Force Field for Peptides and Proteins Based on the Classical Drude Oscillator
- (2013) Pedro E. M. Lopes et al. Journal of Chemical Theory and Computation
- Effect of High Exogenous Electric Pulses on Protein Conformation: Myoglobin as a Case Study
- (2013) Paolo Marracino et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Electric field induced changes in protein conformation
- (2013) Innocent Bekard et al. Soft Matter
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein
- (2012) Sandrine Belouzard et al. Viruses-Basel
- MDAnalysis: A toolkit for the analysis of molecular dynamics simulations
- (2011) Naveen Michaud-Agrawal et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Electric Field-Driven Disruption of a Native β-Sheet Protein Conformation and Generation of a Helix-Structure
- (2010) Pedro Ojeda-May et al. BIOPHYSICAL JOURNAL
- Simulating Monovalent and Divalent Ions in Aqueous Solution Using a Drude Polarizable Force Field
- (2010) Haibo Yu et al. Journal of Chemical Theory and Computation
- Predicting protein flexibility through the prediction of local structures
- (2010) Aurélie Bornot et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- CHARMM: The biomolecular simulation program
- (2009) B. R. Brooks et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Electrical breakdown of water in microgaps
- (2008) Karl Schoenbach et al. PLASMA SOURCES SCIENCE & TECHNOLOGY
- P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation
- (2007) Berk Hess Journal of Chemical Theory and Computation
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started