期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 22, 期 4, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2021.10513
关键词
erythropoietin; dental pulp cells; angiogenesis; proliferation; pulp regeneration
资金
- National Natural Science Foundation of China [81870750, 81700957]
- Natural Science Foundation of Guangdong Province [2016A030310197]
- Fundamental Research Funds for the Central Universities [12ykpy65]
Erythropoietin (EPO) promotes proliferation and angiogenesis of dental pulp cells (DPCs) by stimulating the secretion of angiogenic cytokines, suggesting a potential role in dental pulp repair and regeneration.
Erythropoietin (EPO) is a 34-kDa glycoprotein that possesses the potential for angiogenesis, as well as anti-inflammatory and anti-apoptotic properties. The present study aimed to examine the effect of EPO on the angiogenesis of dental pulp cells (DPCs) and to explore the underlying mechanisms of these effects. It was demonstrated that EPO not only promoted DPCs proliferation but also induced angiogenesis of DPCs in a paracrine fashion. EPO enhanced the angiogenic capacity by stimulating DPCs to secrete a series of angiogenic cytokines. ELISA confirmed that high concentrations of EPO increased the production of MMP-3 and angiopoietin-1 but decreased the secretion of IL-6. Furthermore, EPO activated the ERK1/2 and p38 signaling pathways in DPCs, while inhibition of these pathways diminished the angiogenesis capacity of DPCs. The present study suggested that EPO may have an important role in the repair and regeneration of dental pulp.
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