Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting

E3 ligase Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

(2018) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon

(2018) Lang Yoo et al.   Cell Death & Disease

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

(2018) Claire Dickson et al.   eLife

ISG15 in cancer: Beyond ubiquitin-like protein

(2018) Hye Gyeong Han et al.   CANCER LETTERS

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin

(2016) Eunju Im et al.   Open Biology

Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon

(2015) Daichao Xu et al.   Autophagy

TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity

(2015) Stian Foss et al.   IMMUNOLOGICAL REVIEWS

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

(2015) Adam J. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response

(2015) Anshuman Das et al.   VIROLOGY

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

(2015) Ruth E. Watkinson et al.   PLoS Pathogens

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

New Function of Type I IFN: Induction of Autophagy

(2014) Hana Schmeisser et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis

(2014) Jung Mi Park et al.   MOLECULAR CELL

Type I interferons induce autophagy in certain human cancer cell lines

(2013) Hana Schmeisser et al.   Autophagy

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells

(2012) Shan Zhu et al.   Autophagy

IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function

(2012) Malene Ambjørn et al.   Autophagy

AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization

(2012) F. Hauler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ro52-mediated Monoubiquitination of IKK  Down-regulates NF- B Signalling

(2009) K. Wada et al.   JOURNAL OF BIOCHEMISTRY

The Sequestosome 1/p62 Attenuates Cytokine Gene Expression in Activated Macrophages by Inhibiting IFN Regulatory Factor 8 and TNF Receptor-Associated Factor 6/NF- B Activity

(2009) J. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

(2008) A. H. Keeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA