The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition

PRRX1 deficiency induces mesenchymal‐epithelial transition through PITX2/miR‐200‐dependent SLUG/CTNNB1 regulation in hepatocellular carcinoma

(2021) Weibo Chen et al.   CANCER SCIENCE

Tumor suppressive microRNA‐485‐5p targets PRRX1 in human skin melanoma cells, regulating epithelial‐mesenchymal transition and apoptosis

(2021) Xiaolin Wu et al.   CELL BIOLOGY INTERNATIONAL

microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development

(2020) Keita Funada et al.   Scientific Reports

PRRX1 isoform PRRX1A regulates the stemness phenotype and epithelial-mesenchymal transition (EMT) of cancer stem-like cells (CSCs) derived from non-small cell lung cancer (NSCLC)

(2020) Lei Sun et al.   Translational Lung Cancer Research

PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p

(2019) Jian Jiang et al.   NEOPLASIA

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells

(2019) Benoît Marchand et al.   ONCOGENE

PRRX1‐induced epithelial‐to‐mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis

(2019) Ya‐ping Jiang et al.   CELL PROLIFERATION

Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1

(2019) Yujun Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A gene regulatory network to control EMT programs in development and disease

(2019) Hassan Fazilaty et al.   Nature Communications

HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma

(2018) Wei Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

(2018) Lei Shi et al.   ONCOGENE

Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma

(2017) Mingming Fan et al.   ONCOLOGY REPORTS

Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells

(2017) Yamu Li et al.   Journal of Molecular Cell Biology

LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1

(2017) Bei Wang et al.   PLoS One

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization

(2016) Shigetsugu Takano et al.   GENES & DEVELOPMENT

Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer

(2016) Zhi-Dong Lv et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer

(2016) Zhi-Dong Lv et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters

(2016) Vlasta Němcová-Fürstová et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Roles of the Epithelial-Mesenchymal Transition Marker PRRX1 and miR-146b-5p in Papillary Thyroid Carcinoma Progression

(2014) Heather Hardin et al.   AMERICAN JOURNAL OF PATHOLOGY

PRRX1 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer

(2014) Jinbao Guo et al.   MEDICAL ONCOLOGY

Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells

(2014) MAI SUGIYAMA et al.   ONCOLOGY REPORTS

MiR-124 Radiosensitizes Human Colorectal Cancer Cells by Targeting PRRX1

(2014) Yuqin Zhang et al.   PLoS One

Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

(2013) Y Takahashi et al.   BRITISH JOURNAL OF CANCER

The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

(2013) M. Reichert et al.   GENES & DEVELOPMENT

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients

(2010) Macchia   ONCOLOGY REPORTS

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL