Review
Orthopedics
M. Hall, M. van der Esch, R. S. Hinman, G. Peat, A. de Zwart, J. G. Quicke, J. Runhaar, J. Knoop, M. van der Leeden, M. de Rooij, I. Meulenbelt, T. Vliet Vlieland, W. F. Lems, M. A. Holden, N. E. Foster, K. L. Bennell
Summary: Hip and knee osteoarthritis have distinct characteristics in terms of prevalence, pathophysiology, clinical presentation, and treatment. Researchers should focus on the specificity of hip OA to develop more effective treatments.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas, Lidiane L. Florencio, Ana I. de-la-Llave-Rincon, Ricardo Ortega-Santiago, Margarita Cigaran-Mendez, Stella Fuensalida-Novo, Gustavo Plaza-Manzano, Lars Arendt-Nielsen, Juan A. Valera-Calero, Marcos J. Navarro-Santana
Summary: This study synthesized current evidence on prognostic factors for predicting postoperative pain after knee or hip replacement. The findings suggest that various preoperative factors, including race, opioid use, preoperative function, neuropathic pain symptoms, and anxiety, are associated with postoperative chronic pain. Additionally, certain comorbidities, such as heart disease and lung disease, are not associated with postoperative chronic pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Cecilie Henkel, Unnur Styrkarsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gyda Bjornsdottir, Karina Banasik, Soren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar Rene Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Dbds Genomic Consortium, Thorgeir E. Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kari Stefansson, Anders Troelsen
Summary: This study aimed to investigate the differences in genetic associations between knee and hip osteoarthritis based on joint replacement status. The results showed that genetic correlations varied between patients with knee and hip osteoarthritis, and joint replacement status influenced the genetic associations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Priyanka Ballal, Christine Peloquin, Cindy Germaine Boer, Tuhina Neogi
Summary: This study suggests that warfarin use is associated with a higher risk of knee and hip replacements compared to DOAC use. Furthermore, longer duration of warfarin use is linked to an increased risk of joint replacement.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rehabilitation
Regina Bendrik, Lena Kallings, Kristina Broms, Wanlop Kunanusornchai, Margareta Emtner
Summary: The study aimed to compare the effectiveness of physical activity on prescription with a one-hour advice session in increasing physical activity levels. Despite a significant reduction in pain after walking in the prescription group, there were no significant differences between the two groups in other measures, indicating that individually tailored physical activity prescriptions did not significantly improve physical activity levels more than simple advice.
CLINICAL REHABILITATION
(2021)
Article
Rehabilitation
Melissa A. Boswell, Kris M. Evans, Sean R. Zion, Danielle Z. Boles, Jennifer L. Hicks, Scott L. Delp, Alia J. Crum
Summary: This study compared the mindset about physical activity between individuals with and without knee osteoarthritis (KOA) and found that mindset is associated with future physical activity levels and the individual's management strategy.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Neurosciences
Jessica Lohnes, Nathan Urquhart, Ivan Wong, William Stanish, Derek Rutherford
Summary: This study aimed to determine whether specific gait outcomes previously linked to symptomatic medial compartment knee OA are unique to knee OA. The results showed that there were no differences in knee joint kinematics and moments between the knee OA and asymptomatic groups, but the knee adduction moments were greater in the knee OA group compared to the hip OA group. The knee OA group also exhibited a higher activation ratio of the lateral to medial hamstrings compared to the hip OA and asymptomatic groups. This suggests that medial and lateral hamstring muscle activation levels may provide utility as a knee OA gait biomarker.
Article
Orthopedics
Mastour Saeed Alshahrani, Ravi Shankar Reddy, Faisal Asiri, Jaya Shanker Tedla, Adel Alshahrani, Praveen Kumar Kandakurti, Venkata Nagaraj Kakaraparthi
Summary: This study found a negative correlation between quadriceps endurance and knee joint position sense (JPS) in individuals with knee osteoarthritis (KOA). Compared to asymptomatic individuals, KOA individuals had lower quadriceps endurance and larger knee joint position errors.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
K. Pihl, E. M. Roos, R. S. Taylor, D. T. Gronne, S. T. Skou
Summary: The study found that comorbidities do not affect the health outcomes of individuals with knee and hip osteoarthritis following an exercise and education program, suggesting that exercise remains a viable treatment option for OA patients, regardless of comorbidities.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
E. M. Roos, D. T. Gronne, J. B. Thorlund, S. T. Skou
Summary: This study compared the baseline characteristics and treatment outcomes of patients with symptomatic knee or hip osteoarthritis participating in patient education and exercise therapy. The results showed clinically relevant improvements in both knee and hip patients at 3 and 12 months after treatment. Therefore, patients with knee and hip osteoarthritis should be prioritized for treatment with patient education and supervised exercise therapy.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Sport Sciences
Rana S. Hinman, Michelle Hall, Sarah Comensoli, Kim L. Bennell
Summary: This update Position Statement provides the most recent evidence and guidance for health practitioners managing people with hip/knee osteoarthritis, emphasizing the importance of exercise in reducing joint pain, increasing physical function, and improving quality of life. Exercise dosage should be guided by the principles of the American College of Sports Medicine, and practitioners should actively monitor and promote adherence to exercise for optimal therapeutic benefits.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Health Care Sciences & Services
Johanna Theresia Biebl, Marzena Rykala, Maximilian Strobel, Pawandeep Kaur Bollinger, Bernhard Ulm, Eduard Kraft, Stephan Huber, Andreas Lorenz
Summary: The study showed that Motion Coach is noninferior to physiotherapist evaluations for osteoarthritis patients, with no significant differences in interrater agreement among age, gender, or BMI subgroups. Results confirmed Motion Coach's ability to detect user form during exercise and provide valid feedback to users with musculoskeletal disorders.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Orthopedics
M. A. Holden, B. Metcalf, B. J. Lawford, R. S. Hinman, M. Boyd, K. Button, N. J. Collins, E. Cottrell, Y. Henrotin, J. B. Larsen, H. Master, S. T. Skou, L. M. Thoma, R. Rydz, E. Wellsandt, D. K. White, K. Bennell
Summary: This study developed evidence-informed recommendations for the delivery of best practice therapeutic exercise for people with knee and/or hip osteoarthritis. The final recommendations comprised 54 specific proposition statements across 11 broad domains.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
M. S. Johansson, A. Pottegard, J. Sondergaard, M. Englund, D. T. Gronne, S. T. Skou, E. M. Roos, J. B. Thorlund
Summary: The study investigated the impact of supervised exercise therapy and patient education on opioid use in knee or hip osteoarthritis patients. It found a 10% decrease in opioid use after the intervention, indicating the potential benefit of these interventions in reducing opioid consumption among chronic users.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Sport Sciences
Qianlin Weng, Siew-Li Goh, Jing Wu, Monica S. M. Persson, Jie Wei, Aliya Sarmanova, Xiaoxiao Li, Michelle Hall, Michael Doherty, Ting Jiang, Chao Zeng, Guanghua Lei, Weiya Zhang
Summary: Exercise has similar effects on pain and function to that of oral NSAIDs and paracetamol. Given its excellent safety profile, exercise should be given more prominence in clinical care, especially in older people with comorbidity or at higher risk of adverse events related to NSAIDs and paracetamol.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Rehabilitation
Julie Ronne Pedersen, Soren T. Skou, Ewa M. Roos, Najia Shakoor, Jonas Bloch Thorlund
Summary: This study investigated the effects of a neuromuscular exercise therapy and patient education intervention on knee joint loading in patients with knee osteoarthritis. The results showed that there was no significant change in the medial-to-lateral tibial bone mineral density ratio after the 8-week intervention. However, participants experienced significant improvements in pain, symptoms, physical function, knee-related quality of life, chair stand ability, and walking speed.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Review
Orthopedics
S. R. W. Wijn, G. Hannink, H. Osteras, M. A. Risberg, E. M. Roos, K. B. Hare, V. A. van de Graaf, R. W. Poolman, H. -W. Ahn, J. -K. Seon, M. Englund, M. M. Rovers
Summary: The objective of this study was to identify subgroups of patients with MRI-confirmed degenerative meniscus tears who may benefit from APM compared to non-surgical or sham treatment. The results showed a small improvement in knee pain for the APM group compared to the non-surgical or sham group at 24 months follow-up. However, there were no significant differences in overall knee function and health-related quality of life between the two groups. No relevant subgroup of patients who benefitted from APM was identified.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Halit Selcuk, Ewa M. M. Roos, Dorte T. T. Gronne, Jonas B. B. Thorlund, Zuebeyir Sari, Soren T. Skou
Summary: This study investigated the influence of self-reported knee instability on changes in knee pain and gait speed following patient education and supervised exercise therapy. The results showed that patients with self-reported instability benefited more from the therapy in terms of pain improvement.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Dermatology
Thomas Vedste Aagaard, Kajsa Lindberg, Stig Brorson, Ulla Riis Madsen, Soren T. Skou
Summary: Exercise therapy is effective in treating patients with diabetic foot ulcers (DFUs), and this study describes the development of a 12-week exercise therapy program for DFU patients. The program consists of aerobic and resistance training exercises and was developed with input from healthcare professionals and patients. The preliminary feasibility of the program was assessed, and although recruitment rates were low, patients found the intervention relevant and expressed a desire for further guidance and a more convenient location for the intervention. However, further studies are needed to assess the feasibility of the program.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Orthopedics
James J. J. Young, Alice Kongsted, Rikke Kruger Jensen, Ewa M. M. Roos, Carlo Ammendolia, Soren T. Skou, Dorte T. T. Gronne, Jan Hartvigsen
Summary: This study aimed to explore characteristics associated with comorbid symptoms of lumbar spinal stenosis (LSS) in people with knee or hip osteoarthritis (OA). The results showed that comorbid LSS symptoms were common in these patients and were associated with specific characteristics, which can be used to guide clinical decision-making.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Bryan Yijia Tan, Zack Zhong Sheng Goh, Chien Joo Lim, Michelle Jessica Pereira, Su-Yin Yang, Kelvin Guoping Tan, Alvin Chin Kwong Tan, Phyllis Liang, J. Haxby Abbott, Andrew M. M. Briggs, David J. J. Hunter, Soren T. T. Skou, Julian Thumboo, Josip Car
Summary: This study aims to explore the psychosocial factors that influence short-term and long-term clinical outcomes, productivity, and healthcare utilization in patients with knee OA. The study will collect baseline characteristics of patients and use regression, mediation, and structural equation modeling for analysis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Sport Sciences
Camma Damsted, Jonas Bloch Thorlund, Per Hoelmich, Martin Lind, Claus Varnum, Martin Dalgaard Villumsen, Mogens Strange Hansen, Soren T. Skou
Summary: This study aims to compare the effects of early surgery and exercise and education on mechanical symptoms in patients aged 18-40 with a meniscal tear and self-reported mechanical knee symptoms. The results suggest that early surgery is more effective for relieving self-reported mechanical knee symptoms compared to exercise and education, but it does not improve pain, function, and quality of life.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Rehabilitation
Julie Ronne Pedersen, Dilara Merve Sari, Carsten Bogh Juhl, Jonas Bloch Thorlund, Soren T. Skou, Ewa M. Roos, Alessio Bricca
Summary: This study assessed the effect of exercise therapy for knee osteoarthritis (OA) by comparing different comparator interventions and found that the variability in comparator interventions significantly affects the effectiveness of exercise therapy, which should be routinely assessed in systematic reviews.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Review
Psychology, Clinical
Madalina Jaeger, Graziella Zangger, Alessio Bricca, Mette Dideriksen, Susan M. Smith, Julie Midtgaard, Rod S. Taylor, Soren T. Skou
Summary: The increasing number of people living with multimorbidity due to ageing populations and improved survival has raised concerns about polypharmacy, treatment burden, competing priorities, and poor coordination of care. Self-management programs are commonly included in interventions to address these issues, but there is currently a lack of overview on interventions supporting self-management in patients with multimorbidity.
HEALTH PSYCHOLOGY REVIEW
(2023)
Article
Endocrinology & Metabolism
Sofie Rath Mortensen, Soren T. Skou, Jan Christian Brond, Mathias Ried-Larsen, Therese Lockenwitz Petersen, Lars Bo Jorgensen, Randi Jepsen, Lars Hermann Tang, Neda Esmailzadeh Bruun-Rasmussen, Anders Grontved
Summary: This study objectively measured physical activity patterns in individuals with diabetes and prediabetes compared to those without, and found that individuals with diabetes and prediabetes had shorter daily activity time and lower adherence to recommended levels of physical activity.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Orthopedics
Peter Larsen, Michael S. Rathleff, Ewa M. Roos, Rasmus Elsoe
Summary: This study aimed to establish population-based reference values for the HOOS and its short-form HOOS-12. The results showed that older patients and those with a BMI over 40 had worse HOOS and HOOS-12 scores, which may be clinically important in evaluating treatment outcomes.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Stan R. W. Wijn, Gerjon Hannink, Jonas B. Thorlund, Raine Sihvonen, Martin Englund, Maroeska M. Rovers
Summary: This study compared patients undergoing arthroscopic partial meniscectomy (APM) in randomized controlled trials (RCTs) and prospective cohort studies. Although there were minimal differences in knee pain, overall knee function, and quality of life between the two groups, differences in age and disease severity were observed.
Article
Orthopedics
Lucy S. Gates, Lindsey Cherry, Dorte T. Gronne, Ewa M. Roos, Soren T. Skou
Summary: This study aimed to determine the prevalence of foot pain in knee or hip OA patients participating in the GLA:D(R) program in Denmark, and to investigate the association between foot pain and baseline clinical characteristics. The study found that 12% of participants reported foot pain, and worse knee or hip pain and greater number of painful joints were associated with foot pain.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Rheumatology
Jaimie D. Steinmetz, Garland T. Culbreth, Lydia M. Haile, Quinn Rafferty, Justin Lo, Kai Glenn Fukutaki, Jessica A. Cruz, Amanda E. Smith, Stein Emil Vollset, Peter M. Brooks, Marita Cross, Anthony Woolf, Hailey Hagins, Mohsen Abbasi-Kangevari, Aidin Abedi, Ilana N. Ackerman, Hubert Amu, Benny Antony, Jalal Arabloo, Aleksandr Y. Aravkin, Ayele Mamo Argaw, Anton A. Artamonov, Tahira Ashraf, Amadou Barrow, Lindsay M. Bearne, Isabela M. Bensenor, Alemshet Yirga Berhie, Nikha Bhardwaj, Pankaj Bhardwaj, Vijayalakshmi S. Bhojaraja, Ali Bijani, Paul Svitil Briant, Andrew M. Briggs, Nadeem Shafique Butt, Jaykaran Charan, Vijay Kumar Chattu, Flavia M. Cicuttini, Kaleb Coberly, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Katie de Luca, Edgar Denova-Gutierrez, Samath Dhamminda Dharmaratne, Meghnath Dhimal, Mostafa Dianatinasab, Karsten E. Dreinhoefer, Muhammed Elhadi, Umar Farooque, Hamid Reza Farpour, Irina Filip, Florian Fischer, Marisa Freitas, Balasankar Ganesan, Belete Negese Belete Gemeda, Tamiru Getachew, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Tiffany K. Gill, Mahaveer Golechha, Davide Golinelli, Bhawna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Nima Hafezi-Nejad, Rabih Halwani, Samer Hamidi, Asif Hanif, Netanja Harlianto, Josep Maria Haro, Jan Hartvigsen, Simon Hay, Jeffrey J. Hebert, Golnaz Heidari, Mohammad-Salar Hosseini, Mehdi Hosseinzadeh, Alexander Kevin Hsiao, Irena M. Ilic, Milena Ilic, Louis Jacob, Ranil Jayawardena, Ravi Prakash Jha, Jost B. Jonas, Nitin Joseph, Himal Kandel, Ibraheem M. Karaye, Md Jobair Khan, Yun Jin Kim, Ali-Asghar Kolahi, Oleksii Korzh, Rajasekaran Koteeswaran, Vijay Krishnamoorthy, G. Anil Kumar, Narinder Kumar, Sang-woong Lee, Stephen S. Lim, Stany W. Lobo, Giancarlo Lucchetti, Mohammad-Reza Malekpour, Ahmad Azam Malik, Luiz Garcia Garcia Mandarano-Filho, Santi Martini, Alexios-Fotios A. Mentis, Mohamed Kamal Mesregah, Tomislav Mestrovic, Erkin M. Mirrakhimov, Awoke Misganaw, Reza Mohammadpourhodki, Ali H. Mokdad, Sara Momtazmanesh, Shane Douglas Morrison, Christopher J. L. Murray, Hasan Nassereldine, Henok Biresaw Netsere, Sandhya Neupane Kandel, Mayowa Owolabi, Songhomitra Panda-Jonas, Anamika Pandey, Shrikant Pawar, Paolo Pedersini, Jeevan Pereira, Amir Radfar, Mohammad-Mahdi Rashidi, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Seyed-Mansoor Rayegani, Daniela Ribeiro, Leonardo Roever, Basema Saddik, Amirhossein Sahebkar, Sana Salehi, Lidia Sanchez Riera, Francesco Sanmarchi, Milena M. Santric-Milicevic, Saeed Shahabi, Masood Ali Shaikh, Elaheh Shaker, Mohammed Shannawaz, Rajendra Sharma, Saurab Sharma, Jeevan K. Shetty, Rahman Shiri, Parnian Shobeiri, Diego Augusto Santos Silva, Ambrish Singh, Jasvinder A. Singh, Surjit Singh, Soren Skou, Helen Slater, Mohammad Sadegh Soltani-Zangbar, Antonina Starodubova, Arash Tehrani-Banihashemi, Sahel Valadan Tahbaz, Pascual R. Valdez, Bay Vo, Linh Gia Vu, Linh Gia, Yuan-Pang Wang, Seyed Hossein Yahyazadeh Jabbari, Naohiro Yonemoto, Ismaeel Yunusa, Lyn M. March, Kanyin Liane Ong, Theo Vos, Jacek A. Kopec
Summary: Osteoarthritis, the most common form of arthritis in adults, has a significant impact on functional ability and quality of life. This study estimated the burden of osteoarthritis across different regions and projected an increase in cases by 2050. The findings highlight the need for preventive measures to reduce the burden of osteoarthritis.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Melker S. Johansson, Anton Pottegard, Jens Sondergaard, Martin Englund, Dorte T. Gronne, Soren T. Skou, Ewa M. Roos, Jonas B. Thorlund
Summary: The aim of this study was to investigate the utilization patterns of prescribed analgesics before, during, and after an exercise therapy and patient education program among patients with knee or hip osteoarthritis. The study found that the majority of patients had an increase in analgesic use in the year before the intervention, but a decrease during and after the intervention. A small proportion of patients accounted for more than half of the total analgesic dispensed during the study period.
RHEUMATOLOGY INTERNATIONAL
(2023)
