期刊
VACCINE
卷 39, 期 29, 页码 3794-3798出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2021.05.060
关键词
Avian Influenza; Highly pathogenic avian influenza; Evolution; Vaccine; H5; 2; 3; 4; 4b; Antigenic; Poultry
资金
- UK Department for the Environment, Food and Rural Affairs (Defra)
- Scottish government [SV3400, SV3006, SE2213]
- Welsh government [SV3400, SV3006, SE2213]
- UK Research and Innovation Global Challenges Research Fund One Health Poultry Hub [BB/S011269/1]
- UK Government's Global Challenges Research Fund
- National Institute of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) program National Institutes of Health (NIH) , Department of Health and Human Services [HHSN266200700007C, HHSN272201400008C]
- Royal Veterinary College Strategic Policy Fellowship - Research England's Strategic Priorities Funding
Since 2003, highly pathogenic H5 subtype avian influenza viruses have been circulating in poultry, causing severe impacts on poultry health and production, with current vaccination options potentially suboptimal.
Since 2003, highly pathogenic avian influenza (HPAI) viruses of the H5 subtype have been maintained in poultry, periodically spilling back into wild migratory birds and spread to other geographic regions, with re-introduction to domestic birds causing severe impacts for poultry health, production and food sustain ability. Successive waves of infection have also resulted in substantial genetic evolution and reassortment, enabling the emergence of multiple clades and subtypes within the H5 2.3.4.4 HPAI viruses. Control of AI is principally through either culling or through vaccination using conventional vaccines. Here, we antigenically and genetically characterise the emerging 2020/21 H5NX clade 2.3.4.4 strains and assess cross-reactivity to putative vaccine strains using chicken antisera. We demonstrate significant antigenic differences between commercially available poultry vaccines and currently circulating viruses suggesting that vaccination options might be suboptimal in the current outbreaks. (c) 2021 Published by Elsevier Ltd.
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