期刊
TRENDS IN PARASITOLOGY
卷 37, 期 7, 页码 622-637出版社
CELL PRESS
DOI: 10.1016/j.pt.2021.04.011
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资金
- French Government (Agence Nationale de la Recherche) Investissement d'Avenir programme, Laboratoire d'Excellence (LabEx) 'French Parasitology Alliance for Health Care' [ANR-11-LABX-0024-PARAFRAP]
- European Research Council (ERC) [833309]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [833309]
- European Research Council (ERC) [833309] Funding Source: European Research Council (ERC)
Apicomplexan parasites are unicellular eukaryotes that invade host cells and proliferate within them. Recent progress has been made in uncovering the structural components and proteins involved in rhoptry exocytosis. Revisiting early findings and considering the evolutionary origins of these parasites have contributed to these discoveries.
Apicomplexan parasites are unicellular eukaryotes that invade the cells in which they proliferate. The development of genetic tools in Toxoplasma, and then in Plasmodium, in the 1990s allowed the first description of the molecular machinery used for motility and invasion, revealing a crucial role for two different secretory organelles, micronemes and rhoptries. Rhoptry proteins are injected directly into the host cytoplasm not only to promote invasion but also to manipulate host functions. Nonetheless, the injection machinery has remained mysterious, a major conundrum in the field. Here we review recent progress in uncovering structural components and proteins implicated in rhoptry exocytosis and explain how revisiting early findings and considering the evolutionary origins of Apicomplexa contributed to some of these discoveries.
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