期刊
TRENDS IN IMMUNOLOGY
卷 42, 期 7, 页码 554-574出版社
CELL PRESS
DOI: 10.1016/j.it.2021.05.005
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资金
- National Institute of Allergy and Infectious Diseases [R01AI080615, AI116620, P01AI138949]
The article explores the abilities of ticks in parasitizing hosts, carrying pathogens, and modulating immunity through saliva. It also discusses the development of tick resistance in some hosts and the potential for new preventive strategies against tick-borne infections.
Ticks have an unparalleled ability to parasitize diverse land vertebrates. Their natural persistence and vector competence are supported by the evolution of sophisticated hematophagy and remarkable host immune-evasion activities. We analyze the immunomodulatory roles of tick saliva which facilitates their acquisition of a blood meal from natural hosts and allows pathogen transmission. We also discuss the contrasting immunological events of tick-host associations in non-reservoir or incidental hosts, in which the development of acquired tick resistance can deter tick attachment. A critical appraisal of the intricate immunobiology of tick-host associations can plant new seeds of innovative research and contribute to the development of novel preventive strategies against ticks and tick-transmitted infections.
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