Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yuping Wang, Jin Chen, Yanran Huang, Shengdong Yang, Tao Tan, Nan Wang, Jun Zhang, Caihong Ye, Mengqi Wei, Jinyong Luo, Xiaoji Luo
Summary: Sch B inhibits proliferation, migration, and invasion of osteosarcoma cells and promotes apoptosis. Its mechanisms may be associated with the inhibition of the Wnt/beta-catenin and PI3K/Akt signaling pathways.
Article
Oncology
Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu, Huiyong Shen
Summary: The study demonstrates that CCR9 promotes osteosarcoma lung metastasis by activating the Wnt/beta-catenin signaling pathway, suggesting that CCR9 may be a promising therapeutic target to inhibit lung metastasis and serve as a novel prognostic marker for osteosarcoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Wenping Song, Xuan Wu, Cheng Cheng, Ding Li, Jinhua Chen, Wenzhou Zhang
Summary: This study investigates the impact of ARHGAP9 on lung adenocarcinoma (LUAD) metastasis and sheds light on its molecular mechanism. The findings demonstrate that downregulated ARHGAP9 is correlated with poor prognosis in LUAD patients. ARHGAP9 knockdown enhances LUAD cell proliferation, migration, and invasion while suppressing cell apoptosis and G0G1 cell cycle arrest. RNA sequencing analysis indicates that ARHGAP9 knockdown reduces the expression of DKK2. Silencing ARHGAP9 and overexpressing DKK2 reverses the promoted effects on LUAD cell proliferation, migration, and invasion, and reduces the activity of the Wnt/beta-catenin signaling pathway. Thus, ARHGAP9 knockdown promotes LUAD metastasis by activating the Wnt/beta-catenin signaling pathway through suppressing DKK2, offering a potential strategy for LUAD treatment.
Article
Orthopedics
Fengxiang Pang, Shouchang Ding, Nan Li, Zhipeng Li, Nannan Tian, Chuanjian Shi, Fengwei Zhang, Yongxin Mai, Jinfang Zhang, Junyan Wang
Summary: This study found that gallic acid (GA) suppressed the growth and metastasis of osteosarcoma (OS) cells by modulating the H19-mediated Wnt/β-catenin signaling pathway. These findings suggest that GA may be a promising drug candidate for the treatment of OS.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Pharmacology & Pharmacy
Qiuping Lu, Huakun Huang, Xiaoxuan Wang, Lijuan Luo, Haichao Xia, Lulu Zhang, Jingtao Xu, Yanran Huang, Xiaoji Luo, Jinyong Luo
Summary: In this study, the anti-osteosarcoma (OS) activity of Echinatin (Ecn), a natural active component from licorice, was evaluated and the possible mechanism was explored. It was found that Ecn inhibited the proliferation, migration, and invasion of OS cells, while inducing apoptosis. Ecn also showed synergistic inhibitory effect with cisplatin (DDP) on OS cells. Mechanistically, Ecn inactivated Wnt/β-catenin signaling pathway while activated p38 signaling pathway. These findings provide new insights into the potential therapeutic strategy for OS treatment by combining Ecn with DDP.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Oncology
Jieyu He, Lin Ling, Zhongyue Liu, Xiaolei Ren, Lu Wan, Chao Tu, Zhihong Li
Summary: Osteosarcoma is a common and highly malignant bone tumor, with dysregulated lncRNA expression potentially playing a crucial role in its progression. Particularly, LncRNAs associated with the Wnt signaling pathway may have significant implications for osteosarcoma development and treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Orthopedics
Guo-Dong Han, Jian Dai, Hong-Xia Hui, Jing Zhu
Summary: This study aimed to find potential diagnostic markers associated with immune cell infiltration in osteosarcoma (OS). By comparing gene expression differences between OS patients with and without metastases, 33 significantly downregulated differentially expressed genes (DEGs) were identified. Six critical genes (ALOX5AP, HLA-DOA, HLA-DMA, HLA-DRB4, HCLS1, and LOC647450) were found to be associated with immune infiltration and had high diagnostic value. High expression of ALOX5AP predicted advanced disease stage and overall survival in OS patients. ALOX5AP overexpression inhibited OS development through regulation of the Wnt/beta-catenin signaling pathway, suggesting it as a novel molecular biomarker for enhanced therapy of OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Environmental Sciences
Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song
Summary: The study found that the metabolite PCB29-pQ of polychlorinated biphenyls can induce the metastasis of breast cancer by increasing the expression of cancer stem cell markers and activating the Wnt/beta-catenin pathway, with the overproduction of reactive oxygen species playing a key role in this process.
Article
Oncology
Shuo Yang, Ping Zhou, Lelei Zhang, Xiangpeng Xie, Yuanyi Zhang, Kaida Bo, Jing Xue, Wei Zhang, Faxue Liao, Pengfei Xu, Yong Hu, Ruyu Yan, Dan Liu, Jun Chang, Kecheng Zhou
Summary: Recent studies have shown that VAMP8 is significantly downregulated in osteosarcoma cells and tissues, and low levels of VAMP8 are associated with poor prognosis in osteosarcoma patients. VAMP8 inhibits the migration and invasion of osteosarcoma cells by promoting the degradation of DDX5 and suppressing WNT/beta-catenin signaling and epithelial-mesenchymal transition (EMT). In addition, VAMP8 also promotes autophagy flux. These findings provide new insights into the biological nature driving osteosarcoma metastasis and highlight the modulation of VAMP8 as a potential therapeutic strategy for targeting osteosarcoma metastasis.
CANCER BIOLOGY & THERAPY
(2023)
Article
Orthopedics
Feng-Wei Zhang, Li-Yang Peng, Chuan-Jian Shi, Jian-Chi Li, Feng-Xiang Pang, Wei-Ming Fu, Xiao-Hua Pan, Jin-Fang Zhang
Summary: Osteosarcoma is a common bone tumor in adolescents with unsatisfactory clinical management. Baicalein (BA) was found to have anti-tumor properties in osteosarcoma and the mechanism may involve the upregulation of lncRNA-Neighboring Enhancer of FOXA2 (lncRNA-NEF) and inactivation of Wnt/beta-catenin signaling.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Songou Zhang, Lei He, Jinxiang Shang, Long Chen, Yifan Xu, Xiaozhen Chen, Xinyu Li, Qingchuan Jiao, Songtao Jin, Xujun Hu, Wenqing Liang
Summary: Carvacrol can suppress proliferation, migration, invasion, and promote apoptosis in osteosarcoma cells by regulating the Wnt/beta-catenin signaling pathway.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Yan Hu, Hanshuo Mu, Ying Yang
Summary: PHF8, as a histone demethylase, is upregulated in NSCLC and has a negative correlation with overall survival of patients. Overexpression of PHF8 promotes NSCLC cell proliferation, migration, and invasion through activating the Wnt/beta-catenin signaling pathway. Mechanistically, PHF8 occupies the promoter of Wnt1, leading to transcriptional activation of the Wnt1 gene, thus influencing EMT of NSCLC cells.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Medicine, General & Internal
Lijiao Peng, Qianzheng Liu, Tingrui Wu, Peng Li, Yixia Cai, Xinjian Wei, Yuming Zeng, Junhong Ye, Peicong Chen, Jing Huang, Hao Lin
Summary: In this study, a novel circRNA, hsa_circ_0087302, was identified in osteosarcoma. It was found to be expressed at low levels in osteosarcoma cells, and its overexpression inhibited proliferation, migration, and invasion in these cells. Furthermore, hsa_circ_0087302 was shown to affect the expression of proteins related to the Wnt/beta-catenin signaling pathway. These findings suggest that hsa_circ_0087302 may provide a new direction for the diagnosis and treatment of osteosarcoma.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.