Article
Food Science & Technology
Rayetta G. Henderson, Brian T. Welsh, John M. Rogers, Susan J. Borghoff, Kristen R. Trexler, Marcel O. Bonn-Miller, Timothy W. Lefever
Summary: A study was conducted on rats to determine the potential reproductive or developmental toxicity of cannabidiol (CBD). High doses of CBD caused mortality, moribundity, decreased body weight and food consumption in the adult rats, indicating severe maternal toxicity. No adverse effects were observed on reproductive performance or organs, but hypertrophy/hyperplasia in the thyroid gland, changes in thyroid hormone concentrations, litter loss, and dystocia were observed. Lower mean pup weights were also observed in high-dose group. Based on this study, the No Observed Adverse Effect Levels (NOAELs) for CBD were determined.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lingling Qian, Chen Chen, Liguo Guo, Junping Deng, Xiangling Zhang, Jiexiang Zheng, Genmei Wang, Xiaofei Zhang
Summary: In this study, the developmental and reproductive effects of BPA analogs (BPS, BPF, BPAF) on D. magna were evaluated. The results showed that BPF and BPAF exhibited similar or stronger toxicity compared to BPA. Additionally, exposure to BPs led to behavioral changes and activation of the antioxidant defense system in D. magna. These findings contribute to a better understanding of the toxicity of BPA analogs and provide empirical evidence for finding safe alternatives to BPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxia Wang, Weidong Hao
Summary: Plant growth regulators (PGRs) are widely used pesticides with relatively low toxicity compared to other pesticides. However, excessive use can lead to overexposure. Exposure to PGRs can have toxic effects on various organs in the body, such as the testes, ovaries, liver, kidneys, and brain. Some PGRs are also considered potential endocrine disruptors. Evidence suggests that prenatal and postnatal exposure to PGRs can result in developmental and reproductive toxicity in animals and humans. PGRs can interfere with sex hormone synthesis and secretion, disrupt the reproductive system's structure and function, and harm the growth and development of offspring. This review summarizes the available data on reproductive and developmental toxicity of PGRs in mammals. Comprehensive epidemiological studies are needed in the future to understand the underlying molecular mechanisms of reproductive and developmental toxicity caused by a mixture of PGRs.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Peiyuan Ma, Priyadarshini Mirmira, Chibueze Amanchukwu
Summary: Novel fluoroether compounds with reversed building block connectivity show high ionic conductivity and oxidative stability, with potential for various applications. Raman and other spectroscopic techniques reveal that the solvation of lithium ions is controlled by fluoroether molecular structure, and the oxidative stability correlates with the free solvent fraction. These electrolytes have the ability to be cycled repeatedly with lithium metal and other battery chemistries, indicating a promising development in next-generation battery technologies.
ACS CENTRAL SCIENCE
(2021)
Article
Environmental Sciences
Sofie Svanholm, Moa Safholm, Nanna Brande-Lavridsen, Erika Larsson, Cecilia Berg
Summary: The study utilized the model frog Xenopus tropicalis to investigate the effects of propiconazole exposure on endocrine perturbations and subsequent adverse effects. It was found that propiconazole increased brain aromatase activity and accelerated metamorphosis in tadpoles, indicating a stimulatory effect on the thyroid system. However, at puberty, hepatic and reproductive effects were evident, suggesting persistent disruption of metabolism and male reproductive function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biology
Iuliia Taskaeva, Anna Kasatova, Dmitry Surodin, Nataliya Bgatova, Sergey Taskaev
Summary: Boron neutron capture therapy (BNCT) is a promising treatment method for malignant melanoma, but the lack of selectivity in B-10 accumulation in tumor cells is a major issue. This study aimed to determine the concentrations of lithium in various tissues and analyze its potential toxicity after administration of lithium carbonate. The accumulation efficiency of lithium in the tumor was found to be the highest at a dose of 400 mg/kg.
Article
Environmental Sciences
Elizabeth DiBona, Carol Haley, Simon Geist, Frauke Seemann
Summary: Microplastic pollution is a potential threat to environmental and human health. This study reveals that microplastics are present in all ecosystems and can contaminate food and water sources. Exposure to polyethylene fibers during the development stage of Japanese medaka fish results in delayed hatching and adverse effects at the molecular and organismal levels. These findings suggest a potential risk of polyethylene fiber exposure for wild fish during reproductive development.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Hojun Lee, Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: This study demonstrates the toxic effects of molinate on zebrafish larvae, including reduced viability and successful hatching, and the induction of apoptosis, inflammation, and endoplasmic reticulum stress response. Additionally, molinate exposure leads to abnormal cardiovascular, neuronal, and liver development in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Anatomy & Morphology
Ghazal Ghajari, Mohammad Nabiuni, Elaheh Amini
Summary: The experiment demonstrated that Ganoderma lucidum extract can prevent lithium carbonate-induced testicular toxicity and related lesions by inhibiting oxidative stress and repairing damages, thus protecting the health of the male reproductive system.
Review
Environmental Sciences
Junchao Ma, Zeming Wang, Chao Qin, Tingting Wang, Xiaojie Hu, Wanting Ling
Summary: The widespread use of consumer products containing benzophenone-type ultraviolet filters has led to their presence in the human body and environment. Increasing evidence shows that these filters are endocrine disruptors, raising concerns about their carcinogenicity and effects on reproduction and development. Due to the varied types of benzophenone-type filters and limited toxicity studies, there is a need for a systematic review to expand knowledge on their health risks and identify safer alternatives.
Article
Engineering, Chemical
Mohammad Mahdi A. Shirazi, Aamer Ali, Cejna Anna Quist-Jensen
Summary: In this study, membrane crystallization was used to recover lithium carbonate crystals from synthetic brine solutions. The effects of operating conditions and salt additives on crystallization were investigated. The results showed that feed temperature and the presence of NaCl and KCl had significant impacts on crystal size.
Review
Toxicology
Lindsey Garnick, Christopher Bates, Andrey Massarsky, Pamela Spencer, Priyanka Sura, Andrew D. Monnot, Andrew Maier
Summary: 2-amino-2-methyl-1-propanol (AMP) is commonly used in personal care products as a pH stabilizer. Animal studies suggest that exposure to AMP can lead to post-implantation loss, but only at maternally toxic doses. Our assessment indicates that dermal exposure to AMP from personal care products is unlikely to result in toxicologically significant systemic concentrations, therefore developmental and reproductive toxicity (DART) is not anticipated.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Food Science & Technology
Susan M. Barlow, Claire Terry, Sean Gehen, Marco Corvaro
Summary: This paper presents the results of a rat two-generation study on triclopyr acid and provides a review of all available reproductive and developmental toxicity data from rat studies. The study found that developmental toxicity was only observed at the highest dose, which was likely due to maternal toxicity. Triclopyr was not found to be specifically toxic to reproduction or selectively toxic to the embryo, fetus, or neonate in the rat.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Reproductive Biology
Jeffry Shearer, Gary Wolfe, Mansoora Khaliq, Brian Kaufman, Aruna Sampath, Kelly L. Warfield, Urban Ramstedt, Anthony Treston
Summary: UV-4 is a host-targeted antiviral agent with broad-spectrum activity and low potential for drug resistance mutations. Animal studies showed adverse effects on reproduction and development, including decreased fertility and abnormal embryonic development. These effects are similar to those seen with structurally related drugs, suggesting that UV-4 may have similar adverse outcomes in humans.
REPRODUCTIVE TOXICOLOGY
(2022)