Stem cell therapy in the heart: Biomaterials as a key route

Cardiovascular diseases are one of the main concerns, nowadays causing a high rate of mortality in the world. The majority of conventional treatment protects the heart from failure progression. As a novel therapeutic way, Regenerative medicine in the heart includes cellular and noncellular approaches. Despite the irrefutable privileges of noncellular aspects such as administration of exosomes, utilizing of miRNAs, and growth factors, they cannot reverse necrotic or ischemic myocardium, hence recruiting of stem cells to help regenerative therapy in the heart seems indispensable. Stem cell lineages are varied and divided into two main groups namely pluripotent and adult stem cells. Not only has each of which own regenerative capacity, benefits, and drawbacks, but their turnover also close correlates with the target organ and/or tissue as well as the stage and level of failure. In addition to inefficient tissue integration due to the defects in delivering methods and poor retention of transplanted cells, the complexity of the heart and its movement also make more rigorous the repair process. Hence, utilizing biomaterials can make a key route to tackle such obstacles. In this review, we evaluate some natural products which can help stem cells in regenerative medicine of the cardiovascular system.

Automated summary

Cardiovascular diseases are currently a major concern worldwide, causing a high rate of mortality. Conventional treatments mainly focus on protecting the heart from failure progression, while regenerative medicine in the heart includes both cellular and noncellular approaches. Noncellular approaches have benefits like exosome administration and utilizing miRNAs, but they are unable to reverse necrotic or ischemic myocardium, highlighting the importance of recruiting stem cells for regenerative therapy.