Green synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chemical oxidant-free and mild conditions was developed. This reaction not only shows good functional-group tolerance but also has high scalability. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An atom-economical and efficient method has been developed for synthesizing 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chemical oxidant-free and mild conditions. This reaction not only demonstrates good functional-group tolerance but also exhibits high scalability.