Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
K. Laxmi Swetha, Kavya Sree Maravajjala, Swati Sharma, Rajdeep Chowdhury, Aniruddha Roy
Summary: A pH-responsive carrier was developed for efficient drug delivery to the tumor, showing enhanced efficacy and uniform distribution. Cell uptake and tumor spheroid models demonstrated good intracellular penetration and deep tumor penetration capabilities of these nanoparticles.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan, Hengfeng Yuan
Summary: This study designed a nanocarrier that can regulate the delivery of therapeutic agents into chondrocytes using ROS responsiveness, and confirmed the exact biological mechanisms of this strategy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biophysics
Kaijun Gou, Wei Xin, Jinying Lv, Zihao Ma, Juqin Yang, Lin Zhao, Ying Cheng, Xuchun Chen, Rui Zeng, Heran Li
Summary: The study aimed to develop a nano-drug delivery system that can respond to stimuli intelligently in the tumor microenvironment (TME). A pH-responsive chitosan-modified chiral mesoporous silica nanoparticles (CS-CMSN) was successfully prepared and studied for its physicochemical properties, drug release performance, potential anti-tumor effect, and biological safety. The results showed that CS-CMSN had good encapsulation ability for doxorubicin (DOX) and controllable pH-responsive drug release properties. In vitro cell experiments demonstrated that DOX@CS-CMSN was highly taken up by 4T1 cells, enhanced toxicity to 4T1 tumor cells, and promoted cell apoptosis. CS-CMSN also exhibited good biosafety in vitro and in vivo. Overall, the delivery of DOX by CS-CMSN nanocarriers holds promise for tumor-targeted therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Applied
Eunhye Yang, Ho-Sup Jung, Pahn-Shick Chang
Summary: In this study, a stimulus-responsive polymer complex called capsosomes containing trilaurin-based solid lipid nanoparticles (SLNs) known as CSLNs was prepared for the oral delivery of hydrophilic molecules. The capsosomes showed improved stability and prolonged retention time under small intestinal conditions and bypassed the gastrointestinal tract. These findings demonstrate the potential application of pH-sensitive capsosomes for the oral delivery of food nutraceuticals.
FOOD HYDROCOLLOIDS
(2022)
Article
Materials Science, Biomaterials
Yefei Yu, Jifeng Chen, Shuang Liu, Du Cheng
Summary: A novel ROS-responsive organosilica nanocarrier was successfully synthesized for drug delivery, which exhibited enhanced tumor transport capability through targeting peptide modification. The nanocarrier significantly increased tumor sensitivity to metformin when combined with fasting therapy by down-regulating pro-survival proteins, suggesting its potential as a promising platform for combinatorial therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Multidisciplinary
Shan Mohanan, Xinwei Guan, Mingtao Liang, Ajay Karakoti, Ajayan Vinu
Summary: The design of novel drug delivery systems is crucial in disease treatments, and mesoporous silica nanoparticles (MSNs) have shown great promise due to their stability, tunable morphologies/sizes, and loading capability. Functionalization of MSNs with drugs, imaging, and targeting agents is enabled by the presence of surface silanol groups, making them versatile and popular among researchers. Stimuli-responsive silanol conjugates have emerged as an effective way to deliver therapeutic drugs precisely and on-demand, and it is important to understand the role of surface silanols in MSN as a drug delivery platform. This review provides an analytical understanding of surface silanols, their chemistry, identification methods, and their correlation with properties and performance.
Article
Engineering, Environmental
Yingjian Ma, Yinmin Wang, Rui Zhao, Zhijie Wang, Shuang Li, Meng Yu, Sen Pang, Xinyu Guo, Yong Xu, Xuemin Wu
Summary: Using advanced functional materials and technologies to construct new, efficient, and controlled-release pesticide formulations can effectively improve the target utilization of pesticides and reduce their impact on nontarget organisms and the surrounding environment. The study presents a strategy for preparing pH-responsive nanodrug delivery systems that can release pesticides rapidly in acidic environments. The results show that the nanodrug delivery system has longer-lasting fungicidal activity and lower impact on non-target organisms and the environment. Moreover, it can provide trace elements required by plants to promote crop growth without disturbing normal growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Polymer Science
Khalid M. Alotaibi, Abdurrahman A. Almethen, Abeer M. Beagan, Latifah H. Alfhaid, Maqusood Ahamed, Ahmed M. El-Toni, Abdullah M. Alswieleh
Summary: A new pH-responsive nanosystem based on mesoporous silica nanoparticles (MSNs) was developed for cancer therapy, featuring a gatekeeper PDEAEMA and further modification to encapsulate the anti-cancer drug doxorubicin (DOX). The fabricated nanoplatform exhibited significant drug release and cytotoxicity in acidic media, suggesting its potential as a nanocarrier for anti-cancer drugs.
Article
Biochemistry & Molecular Biology
Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian
Summary: Stimulus-responsive nanomaterials have shown promise in controllable drug delivery systems for cancer therapy. In this study, iron (III) carboxylate metal-organic framework nanoparticles coated with glycyr- rhetinic acid-chitosan conjugate were successfully fabricated as a pH-responsive and target-selective system for delivering doxorubicin to hepatocellular carcinoma cells. The nanocarriers exhibited uniform size, high drug loading efficiency, and pH-dependent controlled drug release. In vitro experiments demonstrated their excellent inhibitory effects on cancer cells and targeted delivery ability. The results suggest that these nanoparticles have potential applications in cancer therapy as a pH-responsive controlled drug delivery system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ghada A. Mahmoud, Hussein E. Ali, Rasha R. Radwan
Summary: A polymeric pH-sensitive nanocarrier was synthesized to deliver pyrogallol, and its anti-tumor activity against colon cancer in rats was investigated. The results showed that pyrogallol-loaded polymeric nanogel significantly reduced tumor incidence and volume. It activated apoptotic pathway and attenuated cell cycle progression. It also exhibited anti-proliferative activity and reduced pro-inflammatory cytokines. The histopathological examination confirmed the results. This formulation could be considered as a promising agent in the treatment of colon cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Joaquin Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cusco, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: Encapsulation of mitochondria-targeted coumarin photosensitizers within nanocapsules improves their photoactivity and reduces cytotoxicity, making them promising agents for nano-photodynamic therapy.
Article
Biochemistry & Molecular Biology
Rosemeyre Cordeiro, Ana Carvalho, Luisa Duraes, Henrique Faneca
Summary: Mesoporous silica nanoparticles show promise as drug delivery systems with high drug loading capacity and biocompatibility. By conjugating with targeting moieties, these particles can overcome limitations of free drugs and improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Kwan-Jip Kim, Gijeong Kim, Jin-Ho Bae, Ji-Joon Song, Hak-Sung Kim
Summary: This study develops a virus-like particle (VLP) that shows pH-responsive assembly and disassembly for targeted drug delivery through the computational design of bacteriophage P22 coat proteins. The cryo-EM structure of the designed VLP is determined, demonstrating the underlying mechanism of pH responsiveness. The utility of the VLP is exemplified by delivering a tumor-targeting cytotoxic protein in a pH-dependent manner.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).