Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

(2020) Benjamin R. Bellenie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural analysis of the PATZ1 BTB domain homodimer

(2020) Sofia Piepoli et al.   Acta Crystallographica Section D-Structural Biology

Structural basis for dimerization quality control

(2020) Elijah L. Mena et al.   NATURE

Small-molecule-induced polymerization triggers degradation of BCL6

(2020) Mikołaj Słabicki et al.   NATURE

Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models

(2019) Julie Ross et al.   CANCER RESEARCH

Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

(2018) Huimin Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dimerization quality control ensures neuronal development and survival

(2018) Elijah L. Mena et al.   SCIENCE

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

An Open-Source, Cross-Platform Resource for Nonlinear Least-Squares Curve Fitting

(2018) Andreas Möglich   JOURNAL OF CHEMICAL EDUCATION

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

(2017) William McCoull et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

(2017) Yusuke Kamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

20 years of the SMART protein domain annotation resource

(2017) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

(2017) Nina Kerres et al.   Cell Reports

A conformational switch regulates the ubiquitin ligase HUWE1

(2017) Bodo Sander et al.   eLife

P13, the EMBL macromolecular crystallography beamline at the low-emittance PETRA III ring for high- and low-energy phasing with variable beam focusing

(2017) Michele Cianci et al.   JOURNAL OF SYNCHROTRON RADIATION

Broad-complex, tramtrack, and bric-à-brac (BTB) proteins: Critical regulators of development

(2016) Edwin Chaharbakhshi et al.   GENESIS

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

(2016) Mariano G. Cardenas et al.   JOURNAL OF CLINICAL INVESTIGATION

Nac1 interacts with the POZ-domain transcription factor, Miz1

(2014) Mark A. Stead et al.   BIOSCIENCE REPORTS

Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress

(2014) Bu-Nam Jeon et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain

(2014) Sian E. Evans et al.   PLoS One

Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1

(2014) Mark Alexander Stead et al.   Acta Crystallographica Section F-Structural Biology Communications

Miz1 is required to maintain autophagic flux

(2013) Elmar Wolf et al.   Nature Communications

High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis

(2012) Sandro Keller et al.   ANALYTICAL CHEMISTRY

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

(2012) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding

(2011) K M Lee et al.   ONCOGENE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

(2010) Leandro C. Cerchietti et al.   CANCER CELL

Transcription Factor Miz-1 Is Required to Regulate Interleukin-7 Receptor Signaling at Early Commitment Stages of B Cell Differentiation

(2010) Christian Kosan et al.   IMMUNITY

Insights into Strand Exchange in BTB Domain Dimers from the Crystal Structures of FAZF and Miz1

(2010) Peter J. Stogios et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

(2008) L. C. Cerchietti et al.   BLOOD

Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation

(2008) Axel Weber et al.   EMBO JOURNAL

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

(2008) Alexandru F. Ghetu et al.   MOLECULAR CELL