Article
Immunology
Xia Cai, Yang Shi, Yue Dai, Fang Wang, Xuepeng Chen, Xiaojun Li
Summary: Baicalin enhances efferocytosis by promoting macrophage engulfment of apoptotic PMNs, inhibiting reactive oxygen species production, and regulating macrophage polarization, thus promoting resolution of inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Bingqing Zhang, Qiang Li, Qinglin Xu, Baochao Li, Heng Dong, Yongbin Mou
Summary: Inflammatory bowel disease (IBD) is closely related to oxidative stress. Developing a novel method to scavenge reactive oxygen species (ROS) and alleviate colon inflammation is a promising strategy. CeO2@PP possesses excellent antioxidant and anti-inflammatory properties for scavenging ROS and modulating macrophage polarization, which is beneficial for efficient colitis therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bo Zhang, Yang Yang, Jianru Yi, Zhihe Zhao, Rui Ye
Summary: The study found that high glucose could polarize macrophages toward M1 macrophages via overproducing ROS, which may be responsible for aggravated periodontal damage in periodontitis under diabetic condition. Inhibiting M1 macrophages and restoring M2 macrophages by ROS scavenger is potentially a adjunct treatment strategy for diabetic periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Immunology
Yongxin Huang, Qinyuan Xu, Jiang Zhang, Yanze Yin, Yixiao Pan, Yuanyi Zheng, Xiaojun Cai, Qiang Xia, Kang He
Summary: The study suggests that PB scavenger could be a potential therapeutic agent for treating HIRI, providing an alternative treatment for ROS-associated and inflammatory liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Liana V. V. Basova, Whitney Vien, Nikki Bortell, Julia A. A. Najera, Maria Cecilia Garibaldi Marcondes
Summary: Methamphetamine abuse is associated with HIV co-morbidity, exacerbating central nervous system inflammation and HIV-associated neurological disorders, and plays a role in the transcriptional regulation of inflammatory genes induced by the drug.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Yuan Gao, Shihong Liu, Xinchun Zeng, Zhixiong Guo, Da Chen, Sanzhong Li, Zhimin Tian, Yongquan Qu
Summary: Endothelial dysfunction induced by severe oxidative stress damage plays a critical role in the pathogenesis and progression of atherosclerosis. This study demonstrates that gadolinium-doped CeO2 nanozymes effectively scavenge reactive oxygen species (ROS) and show promising antiatherosclerosis performance. The Gd/CeO2 nanozymes reduce vascular lesions and lipid accumulation in macrophages, decrease inflammatory factor levels, and can serve as T1-weighted magnetic resonance imaging contrast agents for plaque localization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Yang Wang, Rongjun Wan, Wang Peng, Xincheng Zhao, Wenxuan Bai, Chengping Hu
Summary: This study found that quercetin (QCT) can alleviate neutrophilic airway inflammation associated with ferroptosis and inhibit M1 macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Yue Sun, Xiaolin Sun, Xue Li, Wen Li, Chunyan Li, Yanmin Zhou, Lin Wang, Biao Dong
Summary: In this study, a composite nanomaterial was designed to achieve simultaneous sterilization and inflammation elimination by combining a photosensitizer and ROS scavenger. This nano-based platform can modulate host immunity by down-regulating pro-inflammatory macrophages and up-regulating anti-inflammatory and regenerative macrophages. Additionally, the local ROS level induced by activated inflammation pathway can be adjusted in a very long time due to the charge conversion effect of CeO2, improving the regenerative potential of inflammatory surrounding tissues in the animal model.
Article
Chemistry, Multidisciplinary
Qingshan Liu, Guangyou Shi, Lu Yang, Wu Li, Wang Yang, Qianqian Wu, Ling Zou, Anwei Zhang, Jiang Cao, Jian He, Xiaochao Yang
Summary: The obstacle of smaller-sized ceria nanoparticles accumulating in the spleen and liver rather than the lung can be overcome by constructing ultrafine ceria nanowires, which have high ROS scavenging activity and promote lung targeted accumulation. Longer nanowires (>100 nm) show higher lung accumulation and can effectively scavenge overproduced ROS, inhibiting edema and inflammation in the lung tissue during the progression of acute lung injury (ALI).
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Hsin-Lun Lee, Yao Chen Chuang, Jo-Ting Tsai, Yu-Chen Chen, Ping-Hsiu Wu, Leu-Wei Lo, Jeng-Fong Chiou, Yao-An Shen
Summary: Gold nanomaterials have gained attention in biomedical applications due to their biocompatibility and unique properties. In this study, a gold nanodandelion-based system for scavenging reactive oxygen species (ROS) was developed. The system showed excellent antioxidant properties and could mitigate oxidative stress. The size and surface characteristics of the gold nanomaterials influenced their efficiency in scavenging ROS.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Bingbing Bai, Chaoyu Gu, Xiaohui Lu, Xingyu Ge, Junling Yang, Chenfei Wang, Yongchun Gu, Aidong Deng, Yuehua Guo, Xingmei Feng, Zhifeng Gu
Summary: The study developed a novel ROS-responsive drug delivery system using PDA functionalized nanoparticles to deliver MH for treating periodontitis. This system successfully polarized macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype, preventing tooth loss and reducing inflammatory response.
Article
Immunology
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Gross, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi
Summary: This study investigated the signaling cascade necessary for macrophage recruitment and activation after injury, using transparent zebrafish larvae as a model system. The findings suggest that inhibiting intracellular Ca-2+ release impairs macrophage recruitment and activation, while ROS is necessary for macrophage activation independently of calcium. Neutrophils were found not to be essential for macrophage recruitment and activation in this process. Additionally, Src family kinases Lyn and Yrk and NF-kappa B were identified as key regulators of macrophage activation in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Sport Sciences
Tsubasa Mizokami, Katsuhiko Suzuki
Summary: This study investigated the effects of neutrophil depletion on the liver in mice and found that neutrophils play a critical role in regulating liver stress by controlling inflammation.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Environmental Sciences
Soyeon Jeon, Dong-Keun Lee, Jiyoung Jeong, Sung Ik Yang, Ji-Su Kim, Jinsik Kim, Wan-Seob Cho
Summary: This study investigated the toxicity of microplastics on different cell lines and found that microplastics showed significant toxicity to THP-1 macrophages, with toxicity correlated to the generation potential of reactive oxygen species (ROS). Weathering process reduced the ROS generation potential of microplastics, as weathered microplastics had increased affinity to bind serum protein acting as ROS scavenger.
ENVIRONMENTAL POLLUTION
(2021)
Article
Agriculture, Dairy & Animal Science
Kangshu Lan, Chenglong Shen, Jie Li, Shaowei Zhang, Xinrui Lan, Chuanying Pan, Yongsheng Wang
Summary: The ovary is crucial for animal fertility and livestock breeding industry. SEPT7 is a gene related to ovarian development, and it may affect ovarian traits through the regulation of miR-202. A novel indel locus of SEPT7 was found to be associated with ovarian length.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Lixin Liu, Pengyu Li, Yinghe Zhao, Haiyang Song, Teng Liu, Huiqiao Li, Tianyou Zhai
Summary: This study identifies zeolite-like molecules as potential dielectric materials for 2D semiconductors. These molecules exhibit similar properties to SiO2, the commonly used dielectric material in the Si-based semiconductor industry, and can form ideal interfaces with 2D semiconductors while preserving their intrinsic semiconductor properties. Additionally, the molecules with a zeolite-like backbone demonstrate remarkable environmental stability.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Analytical
Shengyuan Luo, Peng Mei, Yiming Zhang, Gert Frolund Pedersen, Shuai Zhang
Summary: A non-resonant metasurface (NRMS) concept is introduced to improve the isolation of dual-polarized and wideband large-scale antenna arrays. The NRMS can achieve stable negative permeability and positive permittivity along the tangential direction, suppressing mutual couplings of the antenna arrays. Simulations and measurements demonstrate that the proposed NRMS successfully enhances the isolations among all ports of a 4x4 antenna array.
Review
Microbiology
Linhua Xu, Bowen Jiang, Yao Cheng, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng, Shun Chen
Summary: Goose astrovirus (GAstV) was initially identified in 2005, but its pathogenicity in goslings was not recognized until 2016. Since then, it has caused significant mortality, with up to 50% of goslings dying from the disease in China. By December 2022, the virus had spread widely across goose farms in several provinces. The infection primarily affects goslings that are under 3 weeks old, leading to the accumulation of urate in various organs. Understanding the immune response and infection mechanism of GAstV can aid in better studying and preventing the severe disease in goslings.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Xin Zhang, Zheng Xu, Xiangpeng Dai, Xiaoling Zhang, Xueju Wang
Summary: The mutation of crucial genes is important in tumor initiation and development. Non-synonymous mutations in tumor cell genomes produce neoantigens that activate the immune system and show promising therapeutic effects in various cancers. Antigen-loaded dendritic cell vaccines are more effective in inducing immune responses. This review summarizes the recent research on neoantigens, neoantigen-based vaccines, and dendritic cell-based vaccines in pancreatic cancers, highlighting the combination of neoantigens and dendritic cell-based vaccines. This work provides evidence and novel insights for the development of personalized neoantigen-based dendritic cell vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fan Yang, Dan Wang, Xuehua Zhang, Haoqin Fan, Yu Zheng, Zhenghui Xiao, Zhi Chen, Yunbin Xiao, Qiming Liu
Summary: HUPRA syndrome is a rare mitochondrial disease characterized by hyperuricemia, pulmonary hypertension, renal failure, and alkalosis. Variants in the SARS2 gene are believed to cause this syndrome, resulting in impaired mitochondrial protein biosynthesis. This study identified novel compound heterozygous variants of SARS2 and provided further understanding of HUPRA syndrome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jinhong Mei, Yu Liu, Yiyun Sheng, Ying Liu, Limin Chen, Hailong Wang, Minzhang Cheng, Zhenyu Zhai, Linlin Xu
Summary: The study reveals that activating transcription factor 1 (ATF1) plays a critical role in the progression of lung adenocarcinoma by transcriptionally enhancing zinc finger protein 143 (ZNF143) expression, leading to increased proliferation and migration of lung adenocarcinoma cells. High expressions of ATF1 and ZNF143 are associated with poor disease-free survival in lung adenocarcinoma patients. This study provides a potential therapeutic candidate for the treatment of lung adenocarcinoma.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Materials Science, Textiles
Rui Yang, Xinmei Li
Summary: The purpose of this study was to create a porous micro-surface with a rough tertiary structure and develop a long-term sustained-release antibacterial hydrophobic membrane for moist, multi-extreme environments. The membrane exhibited super-hydrophobicity with a contact angle increasing from 30.8 degrees to 156 degrees in aqueous solution at pH 11. Incorporating nanoparticles into the spray layer enhanced membrane surface area and improved the slow-release effect of PVA-coated silver nanoparticles. The antibacterial properties of the composite membrane were optimized when the silver nanoparticles were embedded in the PVA fiber layer, resulting in a 3.1 cm antibacterial circle and sustained-release durability.
FIBERS AND POLYMERS
(2023)
Article
Engineering, Electrical & Electronic
Jiajia Chen, Jiacheng Xu, Zhi Gong, Jiani Gu, Xiao Yu, Chengji Jin, Yue Peng, Yan Liu, Bing Chen, Ran Cheng, Genquan Han
Summary: We have demonstrated experimentally for the first time that ferroelectricity can be controlled by injecting or extracting oxygen vacancies (V-o) reversibly from the interfacial layer (IL) to Hf0.5Zr0.5O2 (HZO). The IL, located between the TiN electrode and HZO thin film, acts as a crucial reservoir for Vo. By adjusting the electrical pre-stress time to modulate the concentration and distribution of V(o), HZO exhibits switchable multiferroelectricity. Additionally, the simulated results using a phase-field polarization switching model accurately reproduce the experimental multiferroelectricity, strongly supporting the mechanism of controlling multiferroelectricity through reversible modulation of V-o migration from IL into HZO.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Industrial
Shuang Huang, Lidong Xu, Ming Lou, Hui Chen, Ke Zhang, Yongbing Li
Summary: An innovative 3D multi-phase numerical model was developed to study the pore formation mechanism in laser-MIG hybrid welding process. The model considered droplet transfer, metallic vapor, and molten pool dynamics, and successfully simulated the entire process of bubble generation, movement, merger, and shrinkage. The study revealed that counterclockwise and clockwise eddies occur in the upper and lower molten pool zones respectively, and a trap zone with near-zero flow velocity appears between them. The clockwise eddy in the lower zone tends to cause keyhole collapse and form bubbles, while the lower flow velocity of the clockwise eddy at high welding speed reduces pore formation.
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2023)
Article
Physics, Multidisciplinary
Yong Chen, Meiyong Huang, Huanlin Liu, Kaixin Shao, Jinliang Zhang
Summary: This article proposes a novel framework called the Domain-Gap Aware Framework for real-world low-light image enhancement (LLIE), which addresses the domain bias issue between synthetic and real-world LL domains. The proposed method has been proven to be effective and has high generalization capacity through numerous experiments. This analysis is expected to promote the development of low-light domain research in different fields.
FRONTIERS IN PHYSICS
(2023)
Article
Multidisciplinary Sciences
Huijuan Zhong, Shu Cheng, Xi Zhang, Bing Xu, Jiayi Chen, Xufeng Jiang, Jie Xiong, Yu Hu, Guohui Cui, Juying Wei, Wenbin Qian, Xiaobing Huang, Ming Hou, Feng Yan, Xin Wang, Yongping Song, Jianda Hu, Yuanhua Liu, Xuejun Ma, Fei Li, Chongyang Wu, Junmin Chen, Li Yu, Ou Bai, Jingyan Xu, Zunmin Zhu, Li Liu, Xin Zhou, Li Huang, Yin Tong, Ting Niu, Depei Wu, Hao Zhang, Chaofu Wang, Binshen Ouyang, Hongmei Yi, Qi Song, Gang Cai, Biao Li, Jia Liu, Zhifeng Li, Rong Xiao, Luqun Wang, Yujie Jiang, Yanyan Liu, Xiaoyun Zheng, Pengpeng Xu, Hengye Huang, Li Wang, Saijuan Chen, Weili Zhao
Summary: Reduced-intensity, non-intravenous ESA with sandwiched radiotherapy has been shown to be effective for early-stage nasal NKTCL, with a high overall response rate and low toxicity.
Article
Mechanics
Xingchen Luo, Jinliang Zhang, Fengwei Yang, Fei He, Yimin Xia
Summary: This study investigates the mechanisms of rock breaking using a disc cutter with front-mounted water jet precutting kerf. The effects of water jet kerf depth (H) and cutter spacing (S) on rock-breaking performance are studied through rock-cutting tests and numerical simulations. It is found that increasing H can reduce the vertical force and rolling force of the disc cutter, but it does not improve the internal crack expansion capacity of the rock. The optimal combination of S=80 mm and H=9 mm can promote main crack expansion and improve rock-cutting efficiency. Microscopic observation reveals that the fracture mechanism for the major crack is tensile type.
ENGINEERING FRACTURE MECHANICS
(2023)
Article
Physiology
Xinwei Wang, Jiulong Song, Peng Xia, Qiang Lin, Anliang Chen, Kai Cheng, Fane Kong, Yi Shi, Xueping Li
Summary: High-intensity interval training (HIIT) is a physical therapy that can alleviate osteoarthritis (OA)-associated hyperalgesia. Cacna2d1, a subunit protein of calcium channel, plays a crucial role in nerve cell activity. However, the effect of HIIT on OA hyperalgesia and the involvement of Cacna2d1 remains unclear. In this study, OA rat models were established using monosodium iodoacetate (MIA) injection, and different groups were compared. Pain threshold, cartilage analysis, Cacna2d1 expression, and pain neurotransmitters were measured. The results demonstrated that HIIT could attenuate OA-associated hyperalgesia, possibly through the down-regulation of Cacna2d1 expression.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2023)
Review
Chemistry, Inorganic & Nuclear
Yefei Jiang, Zhi-yong Zeng, Tongxia Jin, Zhiyong Peng, Lin Xu
Summary: Molecular necklaces (MNs) have attracted attention for their delicate structures and potential applications. However, complex synthetic routes have hindered further development. To overcome this challenge, coordination interactions have been employed to synthesize MNs. This review summarizes the progress in coordination-based MNs, focusing on design strategies and potential applications.
DALTON TRANSACTIONS
(2023)
