期刊
SMALL
卷 17, 期 38, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202101356
关键词
cancer recurrence prevention; cryogel; hemostasis; sonodynamic anticancer; ZIF-8
类别
资金
- National Natural Science Foundation of China [51973172, 51673155]
- Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
- State Key Laboratory for Mechanical Behavior of Materials
- World-Class Universities (Disciplines) and Characteristic Development Guidance Funds for the Central Universities
- Opening Project of the Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2019LHM-KFKT008]
A biomaterials approach using ZIF-8 nanoparticle-enhanced multinetwork cryogels for rapid hemostasis and prevention of tumor recurrence during tumor resection is proposed in this study. The cryogels showed good hemostatic effect and significant cancer cell killing ability under ultrasound, reducing the risk of tumor recurrence post-surgery in a hepatocellular carcinoma model.
The inevitable bleeding during tumor resection greatly increases the risk of tumor recurrence caused by metastasis of cancer cells with blood, and hemostasis and prevention of post-operation tumor recurrence is still a challenge. However, a biomaterials approach for rapid hemostasis during tumor resection and simultaneous prevention of tumor recurrence is rarely reported. Here, zeolitic imidazolate framework (ZIF-8) nanoparticle-enhanced multinetwork cryogels are proposed which provide an integrated treatment regimen for rapid hemostasis through intraoperative blood trigger shape recovery and enhanced coagulation, and prevention of postoperative cancer recurrence via sonodynamic anticancer in a hepatocellular carcinoma model. A series of antibacterial shape memory multifunctional cryogels are synthesized based on glycidyl methacrylate-functionalized quaternized chitosan (QCSG), dopamine-modified hyaluronic acid (HA-DA), and hematoporphyrin monomethyl ether (HMME)-loaded dopamine-modified ZIF-8 (ZDH). Blood loss in different bleeding models confirms good hemostasis of ZIF-8 loading cryogels. Besides, in vitro tests confirm that QCSG/HA-DA/ZDH (QH/ZDH) cryogels significantly killed cancer cells by generating reactive oxygen species under ultrasound. Finally, significantly reduced tumor recurrence after the resection of ectopic hepatocellular carcinoma further confirms the good effect of QH/ZDH cryogels in preventing recurrence by a coordinated strategy of intraoperative hemostasis and postoperative sonodynamic therapy by pH-responsive HMME release, showing great potential in clinical application.
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