Article
Microbiology
Xuanji Li, Jakob Stokholm, Asker Brejnrod, Gisle Alberg Vestergaard, Jakob Russel, Urvish Trivedi, Jonathan Thorsen, Shashank Gupta, Mathis Hjort Hjelmso, Shiraz A. Shah, Morten Arendt Rasmussen, Hans Bisgaard, Soren Johannes Sorensen
Summary: The study found a clear bimodal distribution of antibiotic resistance genes (ARGs) acquired in early life, driven by the composition of the gut microbiome. Various environmental factors significantly impacted ARG load, with the importance of antibiotics diminishing over time since treatment.
CELL HOST & MICROBE
(2021)
Article
Geriatrics & Gerontology
Shuo Sheng, Xianwei Li, Shuo Zhao, Changqing Zheng, Feng Zhang
Summary: Parkinson's disease (PD), the second most prevalent neurodegenerative disease, has both motor and non-motor symptoms. Levodopa is the primary treatment, but it can cause side effects. Recent studies have shown that certain antibiotics have neuroprotective properties, which could be used as therapies for PD. This study aimed to investigate the influence of levodopa on gut bacterial antibiotic resistance in PD rats.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Microbiology
Cuncheng Liu, Huaiying Yao, Cunwen Wang
Summary: This study demonstrates an effective method for the treatment of antibiotic bacterial residue using black soldier fly larvae, which can degrade oxytetracycline and serve as a bioremediation tool. However, it also reveals the presence of abundant antibiotic resistance genes in the larval gut, highlighting the need for further attention in environmental health risk assessments.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Djamel Drider
Summary: Bacteriocins are interesting natural antimicrobial peptides that can be quickly deployed to combat certain antimicrobial-resistant bacterial infections. In situ production of bacteriocins by commensal bacteria can provide a backup plan and enhance the global resistance plan of gut microbiota.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Microbiology
Bich Vu Thi Ngoc, Hai Ho Bich, Gianluca Galazzo, Dung Vu Tien Viet, Melissa Oomen, Trang Nghiem Nguyen Minh, Hoang Tran Huy, Hindrik Rogier van Doorn, Heiman F. L. Wertheim, John Penders
Summary: This study investigated the microbiota composition in humans, domestic animals, water, and processed food in northern Vietnam with a history of antibiotic use. It found lower microbial diversity in individuals who used antibiotics in the past 4 months, with human fecal microbiota being more diverse than nonhuman samples and sharing some amplicon sequence variants with feces from animals, water, and food. There was also a correlation between certain Enterobacteriaceae ASVs and the presence of extended-spectrum beta-lactamase CTX-M-group-2 encoding genes in feces from humans and animals, suggesting exchange of antimicrobial-resistant strains.
Article
Microbiology
Xianghui Liang, Zhipeng Zhang, Hai Wang, Xingbang Lu, Wen Li, Haoran Lu, Ayan Roy, Xuejuan Shen, David M. Irwin, Yongyi Shen
Summary: Early-day prophylactic antibiotic treatment has adverse effects on the gut microbiome and disease resistance in chickens. Long-term antibiotics treatment slows down chicken growth, while short-term treatment increases growth rate, but not significantly.
Article
Multidisciplinary Sciences
Alice Risely, Kerstin Wilhelm, Tim Clutton-Brock, Marta B. Manser, Simone Sommer
Summary: This study of gut bacterial dynamics in wild meerkats over a 20-year period finds that diurnal oscillations in bacterial load and composition eclipse seasonal and lifetime dynamics, with a peak in Clostridium abundance at dawn, associated with temperature-constrained foraging schedules.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Isaac Raplee, Lacey Walker, Lei Xu, Anil Surathu, Ashok Chockalingam, Sharron Stewart, Xiaomei Han, Rodney Rouse, Zhihua Li
Summary: The study aimed to confirm gut microbiota shifts in an animal model of antibiotic treatment and found that antibiotic therapy reduced detectable species of bacteria and increased opportunistic pathogens in the gut microbiota. Furthermore, antibiotic treatment selected for antibiotic-resistant gene enriched subpopulations for many of these pathogens.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Multidisciplinary Sciences
Zoe A. Hansen, Wonhee Cha, Brian Nohomovich, Duane W. Newton, Paul Lephart, Hossein Salimnia, Walid Khalife, Ashley Shade, James T. Rudrik, Shannon D. Manning
Summary: The study reveals that Campylobacter infection is associated with altered resistome composition and increased ARG diversity, raising concerns about the role of infection in the spread of resistance determinants.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Matthew R. Volpe, Jose A. Velilla, Martin Daniel-Ivad, Jenny J. Yao, Alessia Stornetta, Peter W. Villalta, Hsin-Che Huang, Daniel A. Bachovchin, Silvia Balbo, Rachelle Gaudet, Emily P. Balskus
Summary: In this study, small molecule boronic acid inhibitors were developed to inhibit the biosynthesis of the human gut bacterial genotoxin colibactin. These inhibitors effectively block the genotoxic effects of colibactin on eukaryotic cells by engaging with the peptidase ClbP. The availability of these inhibitors allows for precise control over colibactin production, enabling further study of its contributions to colorectal cancer.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Upasana Gupta, Priyankar Dey
Summary: This review comprehensively discusses the impact of gut microbiota modulation on opportunistic bacterial infections. It covers mechanisms such as colonization resistance, nutrient and metabolite-associated factors, mucosal immune response, and commensal-pathogen reciprocal interactions. The review highlights the importance of altered intestinal immuno-metabolic and metabolomic homeostasis in the promotion or prevention of infections, and suggests gut microbiota-centered strategies, like probiotics and fecal microbiota transplantation, as potential interventions to attenuate opportunistic bacterial infections.
Article
Microbiology
Tianshu Feng, Mian Gul Hilal, Yijie Wang, Rui Zhou, Qiaoling Yu, Jiapeng Qu, Huan Li
Summary: Gut microbiomes play significant roles in human health and are affected by various factors. The impact of exercise on gut microbiomes is not well studied, and there are differences in gut microbiomes between Chinese and Pakistani participants. Overall microbial diversity and structure differed between the two nationalities, as did the distribution of antibiotic resistance genes (ARGs) among certain bacterial species.
Review
Microbiology
Mikhail Syromyatnikov, Ekaterina Nesterova, Maria Gladkikh, Yuliya Smirnova, Mariya Gryaznova, Vasily Popov
Summary: High-throughput sequencing has enabled extensive studies on the human gut microbiota. This review analyzes the connection between the gut microbiome and the nationality and religion of individuals. The findings suggest that the gut microbiome composition varies among different ethnic groups and religions, potentially influenced by food preferences. The review also discusses the influence of various pathologies on the bacterial composition of the gut.
Article
Microbiology
Anees A. Sindi, Sarah M. Alsayed, Ibrahim Abushoshah, Diyaa H. Bokhary, Nisreen R. Tashkandy
Summary: This study compares the gut microbiota profiles of CRE-positive and CRE-negative stool samples, finding that CRE-positive samples have lower diversity and are dominated by a few taxonomic clusters such as Enterococcus, Sphingomonas, and Staphylococcus. The most abundant taxon in CRE-positive samples is Pseudomonas, indicating resistance to various antimicrobial drugs and reduced microbial diversity.
Article
Microbiology
Evgenii Olekhnovich, Artem B. Ivanov, Vladimir Ulyantsev, Elena N. Ilina
Summary: Fecal microbiota transplantation (FMT) is used to treat intestinal diseases, but its therapeutic mechanism and donor bacteria colonization in the recipient's intestine remain unclear. Metagenomic analysis of FMT experiments can provide insights into the relationship between the host and gut microbiota. The enrichment of successful gut microbes with antibiotic resistance genes may play a key role in the colonization and redistribution of recipient gut microbiota during FMT.
Article
Biochemistry & Molecular Biology
Andrew G. Briscoe, Sarah Nichols, Hanna Hartikainen, Hazel Knipe, Rachel Foster, Andy J. Green, Beth Okamura, David Bass
Summary: Examination of bird faecal material has revealed the distribution patterns of a wide range of organisms, with particular focus on plant seeds and freshwater organisms. High-throughput sequencing methods now offer detailed insights into faecal contents, aiding in the understanding of parasite and pathogen transport. The study highlights the significant levels of bird-mediated dispersal of parasites and hidden biodiversity revealed through novel sequencing techniques.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Plant Sciences
Bia A. Almeida, Balazs A. Lukacs, Adam Lovas-Kiss, Chevonne Reynolds, Andy J. Green
Summary: Endozoochory by waterfowl is important for a broad range of angiosperms, most of which lack a fleshy fruit. This dispersal function contributes to the formation and maintenance of plant communities and may allow range shifts for plant species under global change. However, our current understanding of what seed or plant traits are important for this dispersal mechanism, and how they relate to variation in waterbird traits, is extremely limited.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Gema L. Batanero, Andy J. Green, Juan A. Amat, Marion Vittecoq, Curtis A. Suttle, Isabel Reche
Summary: Coastal wetlands are valuable aquatic ecosystems with high productivity that provide important services, but are at risk of salinization due to predicted rise of sea level and freshwater extractions. Salinization may shift microbial activity from heterotrophic bacterial-dominated processes towards archaeal-dominated processes, influenced by factors like nitrogen concentration, salinity, and virus abundance. More research is needed to accurately predict future scenarios in coastal wetlands.
Article
Biodiversity Conservation
Marco Milardi, Andy J. Green, Marco Mancini, Paolo Trotti, Mikko Kiljunen, Jyrki Torniainen, Giuseppe Castaldelli
Summary: This study investigated the predation impacts of wels catfish on birds and the population trends of waterbirds. The results showed that wels catfish preyed on birds and had an impact on the reproductive success of waterbirds in the protected area. However, the magnitude of the impact varied in different years.
Letter
Ecology
Carlos Camacho, Juan J. Negro, Johan Elmberg, Anthony D. Fox, Szabolcs Nagy, Deborah J. Pain, Andy J. Green
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Biodiversity Conservation
Yanjie Xu, Andy J. Green, Taej Mundkur, Ward Hagemeijer, Haitham Mossad, Herbert H. T. Prins, Willem F. de Boer
Summary: Existing international frameworks and policies for bird conservation focus more on individual sites rather than the network and connectivity between sites. We propose a three-step quantitative approach to protect bird movement connectivity from a network perspective. This approach can serve as a tool for comprehensive and dynamic monitoring of site network robustness.
Article
Environmental Sciences
Meritxell Gros, Josep Mas-Pla, Alexandre Sanchez-Melsio, Mira Celic, Marc Castano, Sara Rodriguez-Mozaz, Carles M. Borrego, Jose Luis Balcazar, Mira Petrovic
Summary: This study investigates the occurrence, transport, and risks associated with antibiotic residues, antibiotic resistance genes, and antibiotic resistant Escherichia coli in natural springs in an agroecosystem environment. The results show that tetracycline and sulfonamide residues are the most commonly found, and genes conferring resistance to sulfonamides and tetracyclines are present in most springs. Antibiotic resistant E. coli is also detected, but with poor correlations to the concentrations of antibiotic residues and genes. The occurrence of antibiotics, genes, and bacteria is influenced by seasonal variations, hydrological factors, and reactive transport processes. The risk assessment suggests a low risk for both groundwater environment and human health when spring water is used for direct consumption.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Infectious Diseases
Miguel Rabelo-Ruiz, Juan Manuel Peralta-Sanchez, Antonio Manuel Martin-Platero, Ana J. Ruiz, Maria del Mar Agraso, Laura Bermudez, Juan Jose Ariza, Alberto Banos, Eva Valdivia, Manuel Martinez-Bueno
Summary: The global demand for fish products is increasing due to population growth, and aquaculture plays a vital role in meeting this demand. However, misuse of antibiotics in the industry has led to the spread of antimicrobial resistance among pathogenic bacteria. This study analyzed the effects of Allium-derived PTSO on the growth and performance of European seabass juveniles. The results showed a decrease in potentially pathogenic Vibrio and an increase in body weight in fish fed with Allium-derived PTSO, although it also caused changes in the diversity and composition of microbial communities.
Article
Marine & Freshwater Biology
Raquel Jimenez-Melero, Dayana Jarma, Juan Diego Gilbert, Jose Manuel Ramirez-Pardo, Francisco Guerrero
Summary: Mediterranean endorheic wetlands in the context of frequent and unpredictable disturbances exhibit strong effects of local meteorological events on the structure of zooplankton communities. This study assesses the combined role of temperature and salinity in determining the community structure emerging from the egg bank, finding that both factors interact non-linearly and modify the magnitude of their effects.
Article
Limnology
Juan Garcia-de-Lomas, Marc Ventura, Carlos M. Garcia, Jenny Caner, Francisco A. Jimenez-Cantizano, Miguel Alonso, Francisco Hortas
Summary: This article reports the first record of Linderiella jebalae on the Iberian Peninsula, possibly dispersed across the Strait of Gibraltar. The species was found in two temporary ponds in Cadiz, southern Spain, 102 km away from its original location in the Moroccan Atlas Mountain range. Genetic analysis suggests recent dispersal from Morocco to Spain, potentially facilitated by bird migrations. This finding increases the diversity of anostraceans in the Iberian Peninsula to 16 species.
Article
Environmental Sciences
Albert Perlas, Kateri Bertran, Francesc Xavier Abad, Carles M. Borrego, Miquel Nofrarias, Rosa Valle, Lola Pailler-Garcia, Antonio Ramis, Marti Cortey, Vicenc Acuna, Natalia Majo
Summary: This study used artificial streams to simulate natural waterfowl habitats and investigated the persistence of avian influenza viruses. The results showed that temperature and sediments had a significant effect on viral decay in water samples, while temperature had no significant effect in sediment samples. This more realistic experimental approach provides a better assessment of the environmental persistence of avian influenza viruses.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Juan Manuel Peralta-Sanchez, Alban Ansotegui, Francisco Hortas, Stella Redon, Victor Martin-Velez, Andy J. Green, Maria J. Navarro-Ramos, Adam Lovas-Kiss, Marta I. Sanchez
Summary: Recent field data suggests that migratory gulls can disperse dry fruited rice field weeds through their digestive system, providing a long-distance dispersal mechanism. In a feeding experiment, seeds of five common rice field weeds were fed to captive lesser black-backed gulls and their seed survival and germination were analyzed. The results showed high seed survival after gut passage, with varying effects on germination depending on the weed species and seed size. The study highlights the importance of non-classical endozoochory for effective weed management.
Article
Engineering, Environmental
Anna Segues Codina, Natalia Sergienko, Carles M. Borrego, Jelena Radjenovic
Summary: In this study, low-cost reduced graphene oxide sponges functionalized with manganese oxide were used as electrodes for the disinfection of Escherichia coli in water. The functionalization with amino-doped manganese oxide strengthened the bond with the graphene coating and improved the electrochemical stability of the sponge. The results showed significant removal of E. coli, and the experiments demonstrated the irreparable damage to the bacterial cells and the key role of storage temperature in further inactivation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Ecology
Pal Toth, Andy J. Green, David M. Wilkinson, Kane Brides, Adam Lovas-Kiss
Summary: Ducks and geese serve as dispersal vectors for plants, with mallards dispersing more plant species compared to geese. Plant communities and traits dispersed also differ between urban and natural habitats.
ECOLOGY AND EVOLUTION
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
