Article
Rheumatology
Rebecca Heijke, Mathilda Bjork, Ingrid Thyberg, Alf Kastbom, Laura McDonald, Christopher Sjowall
Summary: The study investigated the relationship between patient-reported outcome measure (PROM) scores and organ damage in patients with recent-onset systemic lupus erythematosus (SLE) and early rheumatoid arthritis (RA). The results showed that RA patients had worse PROMs than SLE patients, which improved by month 6 after diagnosis, while SLE patients' PROMs remained stable. The incidence of organ damage in SLE was 13.6 per 100 patient-years.
CLINICAL RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jennifer L. Rogers, Amanda M. Eudy, David Pisetsky, Lisa G. Criscione-Schreiber, Kai Sun, Jayanth Doss, Megan E. B. Clowse
Summary: The study aimed to characterize the clinical manifestations of different SLE subtypes and determine the correlation between patient- and physician-reported measures. Patients with fibromyalgia (FM) reported higher symptom scores, leading to discordance between patient and physician reports regardless of SLE disease activity.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Amanda M. Eudy, Bryce B. Reeve, Theresa Coles, Li Lin, Jennifer L. Rogers, David S. Pisetsky, Lisa G. Criscione-Schreiber, Jayanth Doss, Rebecca Sadun, Kai Sun, Megan E. B. Clowse
Summary: This study explored the use of existing patient-reported outcome (PRO) measures to classify Type 1 and Type 2 systemic lupus erythematosus (SLE) activity. The findings suggest that Type 2 SLE activity can be identified by patient-reported data, but the accuracy in predicting Type 1 activity is lower.
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Resit Yildirim, Tatiana Oliveira, David Alan Isenberg
Summary: In recent years, there have been efforts to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases by using treat-to-target strategy and early intervention strategies with immunosuppressive agents. However, infectious complications due to medication side effects remain a major concern. Vaccination programmes and vaccine immunity play a crucial role in patients with SLE in terms of morbidity and mortality. Although research on vaccines' efficacy and immune response in immunosuppressed patients has increased, there is still a lack of data investigating these parameters for those receiving biological agents, leading to a lack of consensus on a vaccination policy for patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Article
Rheumatology
Kathryn Connelly, Vera Golder, Rangi Kandane-Rathnayake, Eric F. Morand
Summary: SLE remains a disease with high unmet clinical need, and the execution of clinical trials to determine the efficacy of new therapies is challenging due to substantial patient heterogeneity. The current clinician-reported outcome measures of treatment response have notable drawbacks, and there is a research goal to define the optimal clinical trial outcome measure for SLE.
LANCET RHEUMATOLOGY
(2021)
Letter
Dermatology
Mattias Henning, Kristina Ibler, Isabella Loft, Poul Jennum, Maria Didriksen, Henrik Ullum, Christian Erikstrup, Kaspar Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sorensen, Khoa Dinh, Lise Wegner Thorner, Gregor B. Jemec, Ole Pedersen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Rheumatology
Cecilie Henkel, Unnur Styrkarsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gyda Bjornsdottir, Karina Banasik, Soren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar Rene Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Dbds Genomic Consortium, Thorgeir E. Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kari Stefansson, Anders Troelsen
Summary: This study aimed to investigate the differences in genetic associations between knee and hip osteoarthritis based on joint replacement status. The results showed that genetic correlations varied between patients with knee and hip osteoarthritis, and joint replacement status influenced the genetic associations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Hematology
Thorsten Brodersen, Klaus Rostgaard, Cathrine Juel Lau, Knud Juel, Christian Erikstrup, Kasper Rene Nielsen, Sisse Rye Ostrowski, Kjell Titlestad, Susanne G. Saekmose, Ole B. Pedersen, Henrik Hjalgrim
Summary: This study found that blood donors were more likely to participate in health surveys, indicating the presence of the healthy donor effect. Furthermore, blood donation was associated with better self-reported health and healthier lifestyles.
Article
Immunology
Maarten van Wijhe, Kamille Fogh, Steen Ethelberg, Kasper Karmark Iversen, Henrik Nielsen, Lars Ostergaard, Berit Andersen, Henning Bundgaard, Charlotte S. Jorgensen, Bibi F. Ss Scharff, Svend Ellermann-Eriksen, Isik S. Johansen, Anders Fomsgaard, Tyra Grove Krause, Lothar Wiese, Thea K. Fischer, Kare Molbak, Thomas Benfield, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Anders Koch, Christian Erikstrup, Anne-Marie Vangsted, Anna Irene Vedel Sorensen, Henrik Ullum, Robert Leo Skov, Lone Simonsen, Susanne Dam Nielsen
Summary: This study assessed the burden of long COVID among nonhospitalized adults with PCR-confirmed SARS-CoV-2 infection. The results showed that 25 out of 100 cases reported at least one long-COVID symptom. Infected individuals had worse general health, higher odds of various symptoms, particularly loss of taste and smell, and significantly reduced physical and mental health. Female sex and severity of infection were identified as major risk factors for long COVID.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cardiac & Cardiovascular Systems
Hildur M. Aegisdottir, Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Olafur A. Stefansson, Bjarni Gunnarsson, Vinicius Tragante, Gudmar Thorleifsson, Lilja Stefansdottir, Thorgeir E. Thorgeirsson, Egil Ferkingstad, Patrick Sulem, Gudmundur Norddahl, Gudrun Rutsdottir, Karina Banasik, Alex Hoerby Christensen, Christina Mikkelsen, Ole Birger Pedersen, Soren Brunak, Mie Topholm Bruun, Christian Erikstrup, Rikke Louise Jacobsen, Kaspar Rene Nielsen, Erik Sorensen, Michael L. Frigge, Kristjan E. Hjorleifsson, Erna Ivarsdottir, Anna Helgadottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Asmundur Oddsson, Hannes P. Eggertsson, Gisli H. Halldorsson, David A. Jones, Jeffrey L. Anderson, Kirk U. Knowlton, Lincoln D. Nadauld, D. B. D. S. Genomic Consortium DBDS Genomic Consortium, Magnus Haraldsson, Gudmundur Thorgeirsson, Henning Bundgaard, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Sisse R. Ostrowsk, Hilma Holm, Kari Stefansson
Summary: This study investigates the genetics of syncope and provides insight into its pathophysiology and prognostic implications. The results show that syncope has a distinct genetic architecture involving neural regulatory processes and a complex relationship with heart rate and blood pressure regulation. There is also a shared genetic background with poor cardiovascular health. Thorough assessment is important for individuals presenting with syncope.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Mona Ameri Chalmer, Lisette J. A. Kogelman, Ida Callesen, Charlotte Gronvold Christensen, Tanya Ramdal Techlo, Peter L. Moller, Olafur B. Davidsson, Isa A. Olofsson, Michael Schwinn, Susan Mikkelsen, Khoa Manh Dinh, Kaspar Nielsen, Mie Topholm, Christian Erikstrup, Sisse Rye Ostrowski, Ole Birger Pedersen, Henrik Hjalgrim, Karina Banasik, Kristoffer S. Burgdorf, Mette Nyegaard, Jes Olesen, Thomas Folkmann Hansen
Summary: Understanding sex differences in migraine is crucial for improving clinical care. This study provides data on sex differences in migraine presentation from a large European population cohort, showing that females have a higher prevalence and more severe disease burden compared to males.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Article
Medicine, General & Internal
Mona Ameri Chalmer, Lisette J. A. Kogelman, Henrik Ullum, Erik Sorensen, Maria Didriksen, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Kaspar R. Nielsen, Mie Topholm Bruun, Karina Banasik, Soren Brunak, Christian Erikstrup, Ole Birger Pedersen, Sisse Rye Ostrowski, Jes Olesen, Thomas Folkmann Hansen
Summary: Better recognition and extensive research into menstrual migraine are needed, along with a revision of the diagnostic criteria. Increased understanding of menstrual migraine is crucial for improving clinical care, diagnosis, and therapy.
Article
Medicine, General & Internal
Hannes Helgason, Thjodbjorg Eiriksdottir, Magnus O. Ulfarsson, Abhishek Choudhary, Sigrun H. Lund, Erna V. Ivarsdottir, Grimur Hjorleifsson Eldjarn, Gudmundur Einarsson, Egil Ferkingstad, Kristjan H. S. Moore, Narimon Honarpour, Thomas Liu, Huei Wang, Thomas Hucko, Marc S. Sabatine, David A. Morrow, Robert P. Giugliano, Sisse Rye Ostrowski, Ole Birger Pedersen, Henning Bundgaard, Christian Erikstrup, David O. Arnar, Gudmundur Thorgeirsson, Gisli Masson, Olafur Th. Magnusson, Jona Saemundsdottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Anna Helgadottir, Patrick Sulem, Unnur Thorsteinsdottir, Hilma Holm, Daniel Gudbjartsson, Kari Stefansson
Summary: This study aimed to develop protein risk scores for ASCVD risk prediction and compare them with clinical risk factors and polygenic risk scores. The results showed that the protein risk scores were significantly associated with ASCVD events and provided a modest improvement when added to the clinical risk factor model.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Eva A. M. Baerends, Astrid K. Hvidt, Joanne Reekie, Ole S. Sogaard, Nina B. Staerke, Dorthe Raben, Henrik Nielsen, Kristine T. Petersen, Maria R. Juhl, Isik S. Johansen, Susan O. Lindvig, Lone W. Madsen, Lothar Wiese, Lene S. Knudsen, Mette B. Iversen, Thomas Benfield, Kasper K. Iversen, Sidsel D. Andersen, Anna K. Juhl, Lisa L. Dietz, Signe R. Andreasen, Thea K. Fischer, Christian Erikstrup, Palle Valentiner-Branth, Jens Lundgren, Lars Ostergaard, Martin Tolstrup
Summary: SARS-CoV-2 Omicron is rapidly spreading globally, even in regions with high vaccination coverage. A study found that high levels of vaccine-induced antibodies provide partial protection against Omicron breakthrough infections. This is important knowledge to further understand the threshold for protection against new variants and to determine the necessity and timing of booster vaccination.
Letter
Gastroenterology & Hepatology
Simon Mark Dahl Baunwall, Sara Ellegaard Andreasen, Mette Mejlby Hansen, Jens Kelsen, Katrine Lundby Hoyer, Nina Ragard, Lotte Lindgreen Eriksen, Sidsel Stoy, Tone Rubak, Else Marie Skjode Damsgaard, Susan Mikkelsen, Christian Erikstrup, Jens Frederik Dahlerup, Christian Lodberg Hvas
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Dermatology
Pernille Lindso Andersen, Bente Villumsen, Ditte Marie Lindhardt Saunte, Kristoffer Solvsten Burgdorf, Maria Didriksen, Sisse Rye Ostrowski, Lise Wegner Thorner, Christian Erikstrup, Khoa Manh Dinh, Kaspar Rene Nielsen, Thorsten Brodersen, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Ole Birger Pedersen, Gregor Borut Jemec
Summary: This study explores the possible association between HS and ADHD, and finds a positive correlation between ADHD and HS. This result has significant implications for the research on psychiatric comorbidity of HS.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Pernille Lindso Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjorup Saekmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
Summary: This study found two protective HLA alleles, DQB1*06:04 and DRB1*13:02, that can reduce the risk of onychomycosis.
SKIN APPENDAGE DISORDERS
(2023)
Article
Dermatology
P. Lindso Andersen, G. B. Jemec, C. Erikstrup, M. Didriksen, K. M. Dinh, S. Mikkelsen, E. Sorensen, K. R. Nielsen, M. T. Bruun, H. Hjalgrim, T. F. Hansen, S. G. Saekmose, S. R. Ostrowski, D. M. L. Saunte, O. B. Pedersen
Summary: This study investigated the association between HLA alleles and MRSD, identifying five novel associations and confirming one previous association.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)