期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 166, 期 -, 页码 119-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2021.06.002
关键词
Membrane potential; Resonance; Dendritic integration; Subcellular distribution; Neurotransmitter release; Plasticity
资金
- National Institutes of Health (CRCNS program) [NIH R01 MH115832]
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their current I-h are widely distributed and have diverse functions in the central nervous system. The functions of HCN channels involve maintaining membrane potential and slow channel dynamics, playing roles in resonance, synaptic integration, transmitter release, plasticity, and other processes.
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels and the current they carry, I-h, are widely and diversely distributed in the central nervous system (CNS). The distribution of the four subunits of HCN channels is variable within the CNS, within brain regions, and often within subcellular compartments. The precise function of I-h can depend heavily on what other channels are co-expressed. In this review, we give an overview of HCN channel structure, distribution, and modulation by cyclic adenosine monophosphate (cAMP). We then discuss HCN channel and I-h functions, where we have parsed the roles into two main effects: a steady effect on maintaining the resting membrane potential at relatively depolarized values, and slow channel dynamics. Within this framework, we discuss I-h involvement in resonance, synaptic integration, transmitter release, plasticity, and point out a special case, where the effects of I-h on the membrane potential and its slow channel dynamics have dual roles in thalamic neurons. (C) 2021 Elsevier Ltd. All rights reserved.
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