Article
Endocrinology & Metabolism
Martin Schoen, Karin Marcek Malenovska, Michal Nemec, Nikoleta Alchus Laiferova, Igor Straka, Zuzana Kosutzka, Peter Matejicka, Peter Valkovic, Jozef Ukropec, Barbara Ukropcova
Summary: This study investigated the regulation of GDF11 in cerebrospinal fluid (CSF) and blood after exercise. The results showed that running decreased the GDF11 protein content in CSF, indicating its potential role in the exercise-induced cross-talk between periphery and the brain.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Esther Garcia-Esquinas, Rosario Ortola, Antonio Buno, Pablo Olmedo, Fernando Gil, Jose R. Banegas, Beatriz Perez-Gomez, Ana Navas-Acien, Fernando Rodriguez-Artalejo
Summary: This study examined the relationship between blood cadmium levels and serum GDF-15 concentrations in community-dwelling older adults. The results showed a dose-response association between cadmium levels and GDF-15, suggesting that cadmium exposure may be related to enhanced GDF-15 expression.
ENVIRONMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Lu Song, Martin Soderholm, Edith H. Svensson, Yan Borne, Gunnar Engstrom
Summary: Elevated levels of circulating GDF-15 were found to be associated with the incidence of hemorrhagic strokes, independently of other major risk factors. This association has not been previously investigated in the general population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Hiroki Yoshimatsu, Norisuke Kawai, Mari Masuda, Tomofumi Miura, Atsushi Ochiai
Summary: The study found that high serum GDF-15 levels were associated with cachexia symptoms in advanced pancreatic cancer patients, as well as with the activation of signaling pathways involving Akt and JNK in the tumor.
Article
Multidisciplinary Sciences
Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero, Tony Wyss-Coray
Summary: Recent understanding of how the systemic environment impacts lifelong brain development has led to interventions aimed at slowing brain ageing. This study discovered that infusing young cerebrospinal fluid (CSF) into aged brains improves memory function and promotes the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs). The researchers identified serum response factor (SRF) as a mediator of OPC proliferation in response to young CSF, and fibroblast growth factor 17 (Fgf17) as a key target for restoring oligodendrocyte function in the ageing brain.
Article
Genetics & Heredity
Lili Yu, Yajing Zhou, Lijuan Wang, Xuan Zhou, Jing Sun, Jiarui Xiao, Xiaolin Xu, Susanna C. Larsson, Shuai Yuan, Xue Li
Summary: This study used Mendelian randomization analysis to explore the association between GDF-15 levels and gallstone disease. The results suggest that GDF-15 may be a potential therapeutic target for gallstone disease, and the inverse association between GDF-15 levels and diabetic complications validates its therapeutic effects.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Rui Peng, Di Li, Si-Qing Mei, Yan Li
Summary: Elevated levels of GDF-15 were found to be significantly associated with an increased risk of suicidal ideation among patients with depression, with this association partly mediated by low testosterone levels.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Wang-Dong Xu, Qi Huang, Chan Yang, Rong Li, An-Fang Huang
Summary: This study explored the role of growth differentiation factor 15 (GDF-15) in the pathogenesis of systemic lupus erythematosus (SLE). The results showed that serum levels of GDF-15 were increased in SLE patients and associated with disease activity, and GDF-15 gene polymorphisms were related to SLE risk. Animal experiments demonstrated that administration of GDF-15 reduced histological changes and inflammatory cell percentages in lupus mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuhan Zang, Zhengbao Zhu, Yi Xie, Zhen Liu, Jieyun Yin, Pinni Yang, Kaixin Zhang, Xiaoqing Bu, Aili Wang, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Giuliano da Paz Oliveira, Rosilene Motta Elias, Gustavo Bruniera Peres Fernandes, Rosa Moyses, Sergio Tufik, Denis Bernardi Bichuetti, Fernando Morgadinho Santos Coelho
Summary: The study found that patients with narcolepsy have decreased CSF concentration of klotho and increased CSF levels of FGF-23, which may play a role in understanding the pathogenesis of narcolepsy.
Review
Cell Biology
Zahra Hasanpour Segherlou, Masoud Nouri-Vaskeh, Sama Noroozi Guilandehi, Amir Baghbanzadeh, Ramin Zand, Behzad Baradaran, Mohammad Zarei
Summary: GDF-15 plays a complex role in cancer, with both tumor-suppressive and oncogenic effects, and its impact on tumor development is linked to the type and stage of cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Enhao Li, Peihong Chen, Jun Lu, Jiarong Dai, Jufen Yi, Shan Zhang, Hua Jin, Meixiang Guo, Hongtao Wang, Xuemei Yu
Summary: The study aimed to investigate the relationship between serum growth differentiation factor 15 (GDF15) and metabolic abnormalities in Chinese pregnant women. Results showed that serum GDF15 levels were linearly correlated with glucose metabolism indices and triglycerides. As GDF15 levels increased, the risk of metabolic abnormalities also increased, especially in cases with multiple metabolic abnormalities. The findings suggest that serum GDF15 levels could serve as a predictor for metabolic abnormalities during pregnancy.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Boel De Paepe
Summary: This article reviews the role of GDF-15 in various muscle-related diseases and explores its potential as a health biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maria de los Angeles Robinson-Agramonte, Bernadeta Michalski, Belkis Vidal-Martinez, Leyanis Ramos Hernandez, Mabel Whilby Santiesteban, Margaret Fahnestock
Summary: Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) are involved in the pathogenesis and treatment of autism spectrum disorder (ASD), with increased serum levels of IGF-1 and decreased serum levels of proBDNF in ASD subjects, particularly in medicated individuals.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Lilu Ling, Xiao Bi, Lu Yao, Danshu Xie, Wei Ding
Summary: In this study, we found that GDF15 may be associated with malnutrition in patients with ESKD undergoing hemodialysis, and it is likely to be a potential diagnostic biomarker for malnutrition.