Article
Biochemistry & Molecular Biology
Caren Sourij, Faisal Aziz, Sarah Krappinger, Andreas Praschk, Thomas Metzner, Harald Kojzar, Andreas Zirlik, Tatjana Stojakovic, Dieter Paetzold, Dirk von Lewinski, Robert Zweiker, Hubert Scharnagl, Harald Sourij
Summary: This study investigated changes in Lp(a) levels after an acute myocardial infarction. The results showed that Lp(a) levels were the lowest during the acute myocardial infarction and started to increase significantly immediately thereafter, with the highest levels at the post-discharge follow-up.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hector Merenciano-Gonzalez, Victor Marcos-Garces, Jose Gavara, Ana Pedro-Tudela, Maria P. Lopez-Lereu, Jose Monmeneu, Nerea Perez, Cesar Rios-Navarro, Elena de Dios, Ana Gabaldon-Perez, Cristina Albiach, Paolo Racugno, Clara Bonanad, Joaquim Canoves, Francisco J. Chorro, Vicente Bodi
Summary: Residual ST-segment elevation after ST-segment elevation myocardial infarction (STEMI) predicts worse long-term clinical and cardiac magnetic resonance (CMR)-derived structural outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Elin Chorell, Tommy Olsson, Jan-Hakan Jansson, Patrik Wennberg
Summary: The study identified altered lysophospholipids ratios that could predict future risk for STEMI and NSTEMI differently. Patients with STEMI had higher levels of proteins associated with atherosclerosis severity and plaque development, while patients with NSTEMI had higher levels of proteins associated with inflammation and macrophage activation. The markers for STEMI risk were related to unstable plaque development, while NSTEMI was characterized by increased inflammation.
Article
Cardiac & Cardiovascular Systems
Juan Carlos C. Montoy, Yu-Chu Shen, Ralph G. Brindis, Harlan M. Krumholz, Renee Y. Hsia
Summary: The study found that regionalization programs for ST-segment-elevation myocardial infarction did not have a statistically significant impact on the treatment and outcomes of patients with NSTEMIs. Over the study period, there were slight increases in early angiography rates and decreases in mortality rates, but these changes were not directly related to regionalization policies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Chemistry, Analytical
Tero Koivisto, Olli Lahdenoja, Tero Hurnanen, Tuija Vasankari, Samuli Jaakkola, Tuomas Kiviniemi, K. E. Juhani Airaksinen
Summary: This study investigates changes in mechanocardiographic (MCG) signals in patients with ST elevation myocardial infarction (STEMI) and finds that mechanical signals recorded on the chest with accelerometers and gyroscopes can be used to differentiate STEMI patients from stable patients. This study provides a novel approach for early screening of STEMI.
Article
Medicine, General & Internal
Zahra Solati, Arun Surendran, Andrea Edel, Marynia Roznik, David Allen, Amir Ravandi
Summary: The study investigated the roles of OxPCs in myocardial ischemia/reperfusion injury. Results showed that fragmented OxPCs significantly increased during the ischemic period in STEMI patients compared to controls, while non-fragmented OxPCs had reductions. Plasma levels of certain OxPCs were correlated with peak CK levels. These findings suggest a potential therapeutic target for myocardial salvage in patients undergoing reperfusion therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Jeffrey L. Anderson, Stacey Knight, Heidi T. May, Viet T. Le, Jawad Almajed, Tami L. Bair, Kirk U. Knowlton, Joseph B. Muhlestein
Summary: Studies conducted outside the United States have shown that SMuRF-less STEMI patients are common and have a poorer prognosis. This study aimed to determine the proportion and outcomes of SMuRF-less STEMI patients in a large US healthcare population. The results showed that 26.2% of the STEMI patients included in the study did not have SMuRF. Short-term outcomes did not differ significantly between SMuRF-less and SMuRF patients, but long-term outcomes were more favorable for SMuRF-less patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yuzhou Xue, Jian Shen, Weifeng Hong, Wei Zhou, Zhenxian Xiang, Yuansong Zhu, Chuiguo Huang, Suxin Luo
Summary: Numerous studies have shown the association between lipid expression and increased cardiovascular risk in STEMI patients. Machine learning algorithms were used to classify patients into different lipid expression phenogroups, with phenogroup 1 showing the highest cardiovascular risk and poorest prognosis. This analysis highlighted the importance of Lp(a) concentration and HDL-C levels in predicting adverse clinical outcomes in STEMI patients.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Quanmei Ma, Yue Ma, Xiaonan Wang, Shanshan Li, Tongtong Yu, Weili Duan, Jiake Wu, Zongyu Wen, Yundi Jiao, Zhaoqing Sun, Yang Hou
Summary: This study established and validated a non-contrast T1 map-based radiomic nomogram for predicting major adverse cardiac events (MACEs) in acute STEMI patients undergoing PCI. The radiomic signature showed good prognostic ability in both training and test sets, while the nomogram combining radiomic scores and cardiac troponin I demonstrated good discrimination ability for predicting MACEs.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tuncay Kiris, Eyup Avci, Tuba Ekin, Didar Elif Akgun, Mucahit Tiryaki, Arafat Yidirim, Kutluhan Hazir, Bektas Murat, Mehtap Yeni, Rojhad Altindag, Sefa Gul, Baran Arik, Tuncay Guzel, Selda Murat, Ahmet Oz, Mustafa Karabacak, Zihni Aktas, Tarik Yildirim, Baris Kilicaslan, Asim Oktay Ergene
Summary: During the COVID-19 outbreak in Turkey, there was a significant decrease in ST-segment elevation myocardial infarction hospitalization rates and a delay in symptom onset to first medical contact. COVID-19 positive STEMI patients showed higher thrombus grade and mortality rates compared to COVID-19 negative patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Medicine, General & Internal
You Zhang, Shan Wang, Datun Qi, Xianpei Wang, Muwei Li, Zhongyu Zhu, Qianqian Cheng, Dayi Hu, Chuanyu Gao
Summary: This study assessed the changes in care processes and outcomes for ST elevation myocardial infarction (STEMI) patients in Henan province, central China, from 2011 to 2018. The results showed an increase in the use of guideline-recommended treatments and a decrease in in-hospital mortality. However, gaps still exist between clinical practice and guideline recommendations.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Weiyao Chen, Xin Tan, Xiaoyu Du, Qin Li, Meng Yuan, Hui Ni, Yuan Wang, Jie Du
Summary: This study developed a machine-learning model to predict long-term major adverse cardiovascular events (MACEs) in STEMI patients after revascularization. The model, called iPROMPT score, showed good predictive value and performance across different subgroups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biology
Daniela Maria Tanase, Evelina Maria Gosav, Anca Ouatu, Minerva Codruta Badescu, Nicoleta Dima, Ana Roxana Ganceanu-Rusu, Diana Popescu, Mariana Floria, Elena Rezus, Ciprian Rezus
Summary: Despite advancements in diagnosis and treatment, coronary artery disease (CAD) and especially ST-elevation myocardial infarction (STEMI) remain major causes of morbidity and mortality worldwide. Early and accurate diagnosis of cardiac dysfunction is crucial for improving prognosis and outcomes in STEMI patients. Recently, microRNAs (miRNAs) have gained attention as potential biomarkers for myocardial infarction (MI) and acute coronary syndromes (ACS), due to their involvement in heart development, various cardiac processes, and as indicators of cardiac damage. This review discusses the current knowledge on cardiac miRNAs and their functions, with a focus on their potential use as novel circulating diagnostic and prognostic biomarkers in STEMI.
Article
Cardiac & Cardiovascular Systems
A. Xin, Kangshuo Li, Lijing L. Yan, Chanchal Chandramouli, Rundong Hu, Xurui Jin, Ping Li, Mulei Chen, Geng Qian, Yundai Chen
Summary: The study aims to predict infarct size of STEMI patients using machine learning methods. After feature selection, five ML algorithms were used to predict infarct size and evaluate the risk of adverse remodeling based on actual and ML-predicted infarct size. The results showed that ML methods outperformed linear regression in predicting infarct size, and both actual and ML-predicted infarct size were associated with adverse remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Basel Humos, Ziyad Mahfoud, Soha Dargham, Jassim Al Suwaidi, Hani Jneid, Charbel Abi Khalil
Summary: Hypoglycemia is a rare event in patients with ST-elevation myocardial infarction (STEMI), but it increases the risk of mortality, arrhythmias, and other comorbidities regardless of diabetes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
R. E. Raja Shariff, K. S. Ibrahim, R. N. Khir, J. R. Ismail, A. W. Undok
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Raja Ezman Raja Shariff, Khairul Shafiq Ibrahim, Sazzli Kasim
Summary: In this case, a 49-year-old male patient presented with prosthetic valve endocarditis requiring radical debridement and major reconstruction surgery due to high risk for mortality and post-operative complications.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2022)
Article
Medicine, General & Internal
Raja Ezman Faridz Raja Shariff, Hafisyatul Aiza Zainal Abidin, Sazzli Kasim
Summary: This case report highlights an uncommon case of infective endocarditis with bicuspid aortic valve presenting initially with abdominal pain, leading to splenic infarcts and delaying prompt diagnosis. It emphasizes the importance of thorough review in diagnosing infective endocarditis as it can manifest in various clinical forms.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2022)
Article
Medicine, General & Internal
Raja Ezman Faridz Raja Shariff, Sazzli Kasim
Summary: Bioprosthetic valve thrombosis (BVT) is rare and can present with signs of heart failure, shock, or embolism. Managing BVT in patients with concurrent intracerebral haemorrhage poses challenges and underscores the importance of multidisciplinary teamwork and patient involvement in decision making.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Kasim, S. Malek, M. F. Aziz, K. S. Ibrahim
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Chia Fong Lau, Sorayya Malek, Roshan Gunalan, W. H. Chee, A. Saw, Firdaus Aziz
Summary: Machine learning algorithms were used to analyze and predict the healing time of upper limb fractures in children. The study collected pediatric orthopaedic data and applied random forest and support vector regression algorithms for prediction, identifying age, bone part, fracture angulation, and distance as important factors influencing fracture healing.
Article
Multidisciplinary Sciences
Hui Cham, Sorayya Malek, Pozi Milow, Cheen Song
Summary: Data visualisation is important for communicating biodiversity data effectively, as images are easier to understand than numerical values. Citizen Science has helped collect biodiversity data, while Google Earth offers a platform for monitoring biodiversity sites. This study aims to create an online module that combines biodiversity data and visualisation components.
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Kasim, S. Malek, K. S. Ibrahim, D. S. Kumar
EUROPEAN HEART JOURNAL
(2023)
Article
Ecology
Mohd Raznan Ramli, Sorayya Malek, Pozi Milow
Summary: The high diversity of plant species in Malaysian homegardens contributes to the provision of various goods and services, benefiting the environment and promoting ecological sustainability. This paper explores the diversity and vertical structure of useful plant species in Malaysian homegardens, and investigates the impact of homegarden size and socio-economic variables on plant diversity using Self Organizing Map. The results show that plant diversity is influenced by homegarden size and socio-economic factors.
Article
Health Care Sciences & Services
Sazzli Shahlan Kasim, Nurulain Ibrahim, Sorayya Malek, Khairul Shafiq Ibrahim, Muhammad Firdaus Aziz, Cheen Song, Yook Chin Chia, Anis Safura Ramli, Kazuaki Negishi, Nafiza Mat Nasir
Summary: This study validated and compared the performance of four cardiovascular disease risk prediction models in an Asian population. The FRS and RPCE models showed good discrimination but poor calibration in predicting CVD risk. SCORE2 and RPCE outperformed their previous versions, SCORE and PCE, respectively.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Medicine, General & Internal
Raja Ezman Raja Shariff, Hafisyatul Aiza Zainal Abidin, Rizmy Najme Khir, Sazzli Kasim
Summary: This case report highlights a 19-year-old male patient with myocarditis complicated by myocardial infarction with non-obstructive coronary arteries. Despite normal findings on coronary angiogram, cardiac magnetic resonance imaging played a crucial role in providing evidence of underlying ischemia, leading to the diagnosis of myocardial infarction with non-obstructive coronary arteries. This underscores the importance of employing multi-modality imaging in guiding management for this condition.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2022)