期刊
PLACENTA
卷 112, 期 -, 页码 62-65出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2021.06.013
关键词
Cytomegalovirus; Congenital infection; Pregnancy; Antivirals; Placenta
资金
- Australian National Health and Medical Research Council [APP1127717]
- Thrasher Research Fund Early Career Award [RG181876]
- Australia-Germany Joint Research Cooperation Scheme [2017-18/RG162050, 2020-21/RG192195]
- DAAD-Go8
- Wilhelm Sander-Stiftung [2018.121.1/MM-SBT]
- Interdisciplinary Center for Clinical Research (IZKF) of the Faculty of Medicine of FAU [A88/MM-HS]
Congenital infection by human cytomegalovirus is a major cause of fetal malformation in developed countries. The miRNA miR-517a-3p from the chromosome 19 miRNA cluster has been shown to inhibit HCMV replication, offering potential for antiviral therapeutic strategies during pregnancy.
Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes containing miRNA from the chromosome 19 miRNA cluster (C19MC) which confer viral resistance to recipient cells. We show the highly expressed C19MC miRNA miR-517a-3p inhibits HCMV replication and viral protein expression in both fibroblast and trophoblast cell cultures (71.6% and 50.4% inhibition of HCMV DNA at 7 days post infection respectively; p < 0.05). This naturally occurring molecule has potential for opening-up antiviral therapeutic strategies for pregnancy.
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