Review
Chemistry, Multidisciplinary
Alessia Pardo, Andrea Butera, Angela Giordano, Simone Gallo, Maurizio Pascadopoli, Andrea Scribante, Massimo Albanese
Summary: The aim of this study was to evaluate the adjunctive effects of photodynamic therapy (aPDT) on nonsurgical mechanical treatment in patients with periodontitis. The results showed that despite the limited number of RCTs and the great heterogeneity between them, it can be concluded that aPDT in association with nonsurgical periodontal treatment improved the clinical parameters at 3 months.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Snehal Dalvi, Stefano Benedicenti, Tudor Salagean, Ioana Roxana Bordea, Reem Hanna
Summary: This systematic review and meta-analysis evaluated the efficacy of antimicrobial photodynamic therapy (aPDT) in periodontitis, finding no additional benefit in reducing probing pocket depth and increasing clinical attachment level. Well-designed randomized controlled trials are needed to determine the effectiveness of aPDT.
Review
Dentistry, Oral Surgery & Medicine
Nasir Zeeshan Bashir, Har-Amrit Singh, Satnam Singh Virdee
Summary: The use of adjunctive ICG-PDT in non-surgical periodontal therapy leads to significant improvements in probing pocket depth and clinical attachment level at 3 and 6 months post-therapy for chronic periodontitis patients. No adverse events were reported. Additional research is needed to explore variables such as different photosensitiser concentrations and parameters associated with the light source.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Microbiology
Leila Gholami, Shiva Shahabi, Marzieh Jazaeri, Mahdi Hadilou, Reza Fekrazad
Summary: With the emergence of resistant bacterial strains and novel microorganisms that pose a global threat to human life, there is an urgent need for new treatment modalities for microbial infections. Antimicrobial photodynamic therapy (aPDT) has shown promise as a non-invasive and effective treatment for oral infectious diseases. Many studies have investigated its efficacy in eliminating bacterial, fungal, and viral infections, with a focus on key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis. Clinical studies have also explored methods of enhancing the efficacy of aPDT through the development of natural, nano-based, and targeted photosensitizers. However, further randomized controlled trials are needed to establish effective clinical protocols and parameters for this treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Tulio Morandin Ferrisse, Luana Mendonca Dias, Analu Barros de Oliveira, Claudia Carolina Jordao, Ewerton Garcia de Oliveira Mima, Ana Claudia Pavarina
Summary: Antimicrobial photodynamic therapy (aPDT) is an effective treatment for oral antisepsis against antibiotic resistant and non-resistant microorganisms. However, more randomized clinical trials are needed to validate the current results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Maarten A. Meire, Juliana D. Bronzato, Rafael A. Bomfim, Brenda P. F. A. Gomes
Summary: This systematic review analyzed the effectiveness of adjunct therapy for apical periodontitis in permanent teeth, but there is currently insufficient evidence to recommend any specific adjunct therapy.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jun-ichiro Hayashi, Kohta Ono, Yuki Iwamura, Yasuyuki Sasaki, Tasuku Ohno, Ryoma Goto, Eisaku Nishida, Genta Yamamoto, Takeshi Kikuchi, Naoya Higuchi, Akio Mitani, Mitsuo Fukuda
Summary: This study introduced a new aPDT method using transgingival Near-infrared (NIR) wavelength and nanoparticles as a photosensitizer in periodontal therapy. The results showed that this method can effectively reduce bacteria count without pain or discomfort.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Oncology
Snehal Dalvi, Stefano Benedicenti, Reem Hanna
Summary: This systematic review evaluated the effectiveness of antimicrobial photodynamic therapy in managing aggressive periodontitis. Out of 11 eligible studies included, there was inconclusive evidence on the ideal photosensitizer dye-wavelength combination and optimal parameters, highlighting the need for standardized and replicable research protocols.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Engineering, Biomedical
Marcella Goetz Moro, Veronica Franco de Carvalho, Bianca A. Godoy-Miranda, Claudio Teruo Kassa, Anna Carolina Ratto Tempestini Horliana, Renato Araujo Prates
Summary: The study evaluated the effect of aPDT as an adjunct to SRP in chronic periodontal patients, showing that the combination of SRP and aPDT promoted significant CAL gain and PPD reduction. Indocyanine green-mediated aPDT and high concentrations of phenothiazine chloride demonstrated favorable clinical improvement.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Marwan El Mobadder, Samir Nammour, Kinga Grzech-Lesniak
Summary: This study evaluated the effectiveness of photodynamic therapy (PDT) using tolonium chloride and a 635 nm diode laser as an adjunct to non-surgical periodontitis treatment. The results showed that PDT significantly contributed to the non-surgical treatment of periodontitis, with reductions in plaque index, bleeding on probing, probing pocket depth, and clinical attachment loss. The combination of SRP and PDT resulted in further improvements compared to SRP alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Noopur P. Gonde, Surekha R. Rathod, Abhay P. Kolte
Summary: This study compared the efficacy of 1% melatonin gel as an adjunct to non-surgical periodontal therapy (NSPT) in the treatment of intrabony defects. The results showed that the use of 1% melatonin gel led to better clinical and radiographic outcomes, with improved intrabony defect fill and bone volume.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Engineering, Biomedical
Yeke Chen, Fang Dai, Tian Deng, Lijie Wang, Yuting Yang, Chenjiang He, Qiangdong Liu, Jianxin Wu, Fanrong Ai, Li Song
Summary: In this study, a multi-functional and sustained release drug delivery system (MB/BG@LG) was developed by encapsulating methylene blue (MB) and bioactive glass (BG) into the lipid gel (LG) precursor by Macrosol technology. MB/BG@LG exhibited excellent adhesion properties, self-assembly properties, and superior drug release control capabilities, which improved the clinical feasibility of its application in complex oral environments.
MATERIALS TODAY BIO
(2023)
Article
Infectious Diseases
Stefanie Anna Peikert, Anil Fischer, Anne Brigitte Kruse, Ali Al-Ahmad, Johan Peter Woelber, Kirstin Vach, Andreas Braun, Petra Ratka-Krueger
Summary: The study found that transgingival visible light and water-filtered infrared-A (VIS + wIRA) did not show additional healing effect in the treatment of periodontitis patients. However, patients reported less pain on the irradiated quadrant after treatment.
Review
Oncology
Yuxin Zhao, Rui Pu, Yinjie Qian, Jue Shi, Misi Si
Summary: The clinical efficacy of adjunctive antimicrobial photodynamic therapy and antibiotics in the treatment of periodontitis and peri-implantitis showed equal evidence, with significant reduction of the red complex in both diseases. However, due to protocol heterogeneity in studies and limited number of trials, the comparative conclusion remains inconclusive. Future long-term clinical trials with standardized protocols are needed to provide a firm conclusion.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Stefano Corbella, Elena Calciolari, Nikolaos Donos, Alice Alberti, Pinar Ercal, Luca Francetti
Summary: This systematic review examines the clinical efficacy of non-surgical periodontal treatment (NSPT) in association with laser therapy (LT) or photodynamic therapy (PDT) in diabetic patients. The results show that PDT significantly improves periodontal pocket depth changes at 6 months, while LT significantly improves pocket depth and clinical attachment loss changes at 3 months. However, caution should be exercised in interpreting these results due to small effect sizes and statistical heterogeneity, and further well-designed randomized controlled trials are needed to support the routine use of PDT or LT in adjunct to NSPT.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tarik Ocon Braga Polo, Gustavo Antonio Correa Momesso, William Phillip Pereira Silva, Anderson Maikon de Souza Santos, Joao Matheus Fonseca-Santos, Nilson Cristino da Cruz, Valentim A. R. Barao, Valdir Gouveia Garcia, Leticia Helena Theodoro, Leonardo P. Faverani
Summary: The study found that both PEO and PBM are effective strategies for bone repair in fractures, but their combination does not provide additional advantages.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Henrique Hadad, Ana Flavia Piquera Santos, Lais Kawamata de Jesus, Pier Paolo Poli, Ronaldo Cello Mariano, Leticia Helena Theodoro, Carlo Maiorana, Francisley Avila Souza
Summary: The study demonstrated that PBM therapy significantly reduced pain and edema after the extraction of retained third molars, suggesting it as a potential adjuvant therapy following surgical procedures.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
Marina Modolo Claudio, Marta Aparecida Alberton Nuernberg, Joao Victor Soares Rodrigues, Licia Clara Garcia Belizario, Julia Arruda Batista, Cristiane Duque, Valdir Gouveia Garcia, Leticia Helena Theodoro
Summary: This study showed that multiple sessions of aPDT as an adjuvant therapy during non-surgical treatment can provide additional clinical benefits, reducing the number of residual pockets and PD means in deep pockets of patients with periodontitis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Vivian Cristina Noronha Novaes, Edilson Ervolino, Giovani Lopes Fernandes, Clara Possarle Cunha, Leticia Helena Theodoro, Valdir Gouveia Garcia, Juliano Milanezi de Almeida
Summary: Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of inflammation and compromised tissue repair by reducing cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Dentistry, Oral Surgery & Medicine
Valdir Gouveia Garcia, Daniela Maria Janjacomo Miessi, Tiago Esgalha da Rocha, Natalia Amanda Gomes, Marta Aparecida Alberton Nuernberg, Janderson de Medeiros Cardoso, Edilson Ervolino, Leticia Helena Theodoro
Summary: The study evaluated the effects of probiotic Lactobacillus reuteri as an adjunct to the treatment of experimental periodontitis. The results showed that the use of Lactobacillus reuteri reduced inflammation and enhanced periodontal tissue repair.
SAUDI DENTAL JOURNAL
(2022)
Letter
Surgery
Mirela C. Silva, Tiburtino J. d. L. Neto, Mateus D. Pavelski, Stefany Barbosa, Anderson M. S. Santos, Daniela A. Brandini, Valdir G. Garcia, Leticia H. Theodoro, Leonardo P. Faverani
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Arles Naisa Amaral Silva, Ingra Gagno Nicchio, Barbara Roque da Silva, Mauricio Gandini Giani Martelli, Marco A. Rimachi Hidalgo, Rafael Nepomuceno, Leticia H. Theodoro, Joni A. Cirelli, Silvana R. P. Orrico, Thamiris Cirelli, Silvana P. Barros, Raquel M. Scarel-Caminaga
Summary: This study found that AGER rs184003, RBMS1 rs7593730, and VEGFA rs9472138, which are considered genetic markers for T2DM, are associated with periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Joao Victor S. Rodrigues, Maria Clara F. Poli, Pedro H. Petrilli, Rita Cassia M. Dornelles, Karina H. Turcio, Leticia H. Theodoro
Summary: The aim of this systematic review was to find clearer evidence on the relationship between food selectivity or food neophobia (FN) and autism spectrum disorder (ASD) in children. The results showed that children with ASD are more selective than those with neurotypical development (NTD), but only half of the studies found higher levels of FN in the ASD group. This highlights the need for studies comparing FN between siblings with ASD and those with NTD in the same family nucleus, and atypical oral sensitivity seems to be the sensory characteristic most related to eating disorders.
Article
Oncology
Edilson Ervolino, Mariane Bocalon Olivo, Luan Felipe Toro, Jessica de Oliveira Alvarenga Freire, Vinicius Franzao Ganzaroli, Isabella Zacarin Guiati, Marta Aparecida Alberton Nuernberg, Joao Paulo Soares Franciscon, Luciano Tavares Angelo Cintra, Valdir Gouveia Garcia, Mark Wainwright, Leticia Helena Theodoro
Summary: This study evaluated the effectiveness of antimicrobial photodynamic therapy (aPDT) mediated by butyl toluidine blue (BuTB) in preventing the occurrence of medication-related osteonecrosis of the jaws (MRONJ)-like lesions after tooth extraction in rats. The findings showed that aPDT mediated by BuTB can effectively prevent the occurrence of MRONJ-like lesions in this animal model.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Thamiris Cirelli, Ingra G. Nicchio, Diego G. Bussaneli, Barbara R. Silva, Rafael Nepomuceno, Silvana R. P. Orrico, Joni A. Cirelli, Leticia H. Theodoro, Silvana P. Barros, Raquel M. Scarel-Caminaga
Summary: SNPs and haplotypes of the PPARG gene were found to be associated with susceptibility to develop periodontitis and type 2 diabetes mellitus. The study also evaluated the gene-phenotype association and found associations with obesity, lipid, glycemic, and periodontal characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Tarik Ocon Braga Polo, Joao Matheus Fonseca-Santos, Gustavo Antonio Correa Momesso, William Phillip Pereira da Silva, Stefany Barbosa, Anderson Maikon de Souza Santos, Mirela Caroline Silva, Valdir Gouveia Garcia, Leticia Helena Theodoro, Leonardo P. Faverani
Summary: This study evaluated the effects of infrared laser (IRL) on bone repair in rats with ovariectomies. The results showed that IRL increased bone turnover and promoted new bone formation, especially in rats with low bone mineral density. These findings suggest that IRL could be used intraoperatively to optimize bone repair.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Laryssa de Castro Oliveira, Vitoria Marega Marchetti, Fernanda de Souza e Silva Ramos, Alberto Carlos Botazzo Delbem, Marina Trevelin Souza, Bernhard Ganss, Leticia Helena Theodoro, Ticiane Cestari Fagundes
Summary: This study investigates the effect of in-office desensitizing materials on dentin permeability and tubule occlusion. The results show that SBU and AMTN solution are more effective in reducing dentin permeability by occluding dentin tubules.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Public, Environmental & Occupational Health
Paulo Sedlaceck, Wilson Roberto Poi, Marina Fuzette Amaral, Lithiene Ribeiro Castilho, Sonia Regina Panzarini, Celia Tomiko Matida Hamata Saito, Daniela Atili Brandini
Summary: The study evaluated the educational effect of notebook covers illustrated with figures and informative texts on tooth avulsion and replantation in sixth-grade primary school pupils. The use of these notebook covers led to a significant increase in knowledge among schoolchildren about tooth avulsion, first aid, and replantation, as shown by improvements in understanding dental trauma, correct procedures for avulsion, storing the avulsed tooth in milk, dental anatomy knowledge, and ideal time for tooth replantation.
HEALTH EDUCATION & BEHAVIOR
(2022)
Review
Dentistry, Oral Surgery & Medicine
Leticia Helena Theodoro, Rosemary Adriana Chierici Marcantonio, Mark Wainwright, Valdir Gouveia Garcia
Summary: This paper reviews the use of lasers in periodontal treatment, indicating that diode lasers have additional clinical benefits in non-surgical periodontal therapy, while Er:YAG lasers are the most suitable type of laser. Different types of lasers can be used for tissue vaporization in periodontal surgery, and photobiomodulation therapy also has a positive effect on promoting tissue repair.
BRAZILIAN ORAL RESEARCH
(2021)
