Rational Development of Stable PYY3–36 Peptide Y2 Receptor Agonists

A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

(2019) Shamina M. Rangwala et al.   Cell Metabolism

The Glucagon-Like Peptide 2 Analog Teduglutide Reversibly Associates to Form Pentamers

(2019) John S. Philo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Half-Life Extending Modifications of Peptide YY3–36 Direct Receptor-Mediated Internalization

(2019) Esben M. Bech et al.   MOLECULAR PHARMACEUTICS

The Effect of Lipidation on the Self-Assembly of the Gut-Derived Peptide Hormone PYY3–36

(2018) Jessica A. Hutchinson et al.   BIOCONJUGATE CHEMISTRY

Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y2Receptor

(2018) Bo Xu et al.   MOLECULAR PHARMACOLOGY

Emerging therapeutic potential for peptide YY for obesity-diabetes

(2018) Ryan A. Lafferty et al.   PEPTIDES

Conformation and Aggregation of Selectively PEGylated and Lipidated Gastric Peptide Hormone Human PYY3-36

(2018) Valeria Castelletto et al.   BIOMACROMOLECULES

Design of Y2 Receptor Selective and Proteolytically Stable PYY3–36 Analogues

(2018) Søren Østergaard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insulin Formulation Characterization—the Thioflavin T Assays

(2016) Morten Schlein   AAPS Journal

Extension of in vivo half-life of biologically active molecules by XTEN protein polymers

(2016) Vladimir N. Podust et al.   JOURNAL OF CONTROLLED RELEASE

Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin

(2016) Christian Fogt Hjorth et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hydrophobic contacts specifically contribute to peptide binding at the neuropeptide Y2 receptor

(2016) Anette Kaiser et al.   NEUROPEPTIDES

Metabolism of peptide YY 3–36 in Göttingen mini-pig and rhesus monkey

(2016) Jørgen Olsen et al.   PEPTIDES

Reaction Pathways in Catechol/Primary Amine Mixtures: A Window on Crosslinking Chemistry

(2016) Juan Yang et al.   PLoS One

Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2Receptor Binding and Activation

(2015) Anette Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

(2015) Jesper Lau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transformation of Oligomers of Lipidated Peptide Induced by Change in pH

(2015) Ying Wang et al.   MOLECULAR PHARMACEUTICS

Strategic Approaches to Optimizing Peptide ADME Properties

(2014) Li Di   AAPS Journal

Protein helical structure determination using CD spectroscopy for solutions with strong background absorbance from 190 to 230nm

(2014) Yang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein aggregation and its impact on product quality

(2014) Christopher J Roberts   CURRENT OPINION IN BIOTECHNOLOGY

The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On

(2013) Sean Manning et al.   Annual Review of Physiology

Mutagenesis and Computational Modeling of Human G-Protein-Coupled Receptor Y2 for Neuropeptide Y and Peptide YY

(2013) Bo Xu et al.   BIOCHEMISTRY

Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery

(2013) Jens Juul Holst   CURRENT OPINION IN PHARMACOLOGY

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

(2013) A. M. Habib et al.   DIABETOLOGIA

The future role of gut hormones in the treatment of obesity

(2013) Rachel C. Troke et al.   Therapeutic Advances in Chronic Disease

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

(2012) Akila De Silva et al.   Gut and Liver

Understanding protein aggregation from the view of monomer dynamics

(2012) Lisa J. Lapidus   Molecular BioSystems

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

(2012) Ib Jonassen et al.   PHARMACEUTICAL RESEARCH

Long-Acting Lipidated Analogue of Human Pancreatic Polypeptide Is Slowly Released into Circulation

(2011) Kathrin Bellmann-Sickert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides

(2010) Hongqian Yang et al.   ELECTROPHORESIS

PEG-modified biopharmaceuticals

(2009) Pascal Bailon et al.   Expert Opinion on Drug Delivery

The role of gut hormones in the regulation of body weight and energy homeostasis

(2009) Efthimia Karra et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gut hormones: Implications for the treatment of obesity

(2009) Marianne T. Neary et al.   PHARMACOLOGY & THERAPEUTICS

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES