Article
Environmental Sciences
Yang Su, Ling Li, Muhammad Umer Farooq, Xin Huang, Tengda Zheng, Yu Jie Zhang, Hla Hla Ei, Faiz Hussain Panhwar, Zhichen Tang, Rui Zeng, Yuanke Liang, Xiaoying Ye, Xiaomei Jia, Jianqing Zhu
Summary: The study explored the mitigating effect of Se-enriched rice on mice poisoned with Cd, finding that the Se-enriched diet enhanced antioxidant capacity, reduced oxidative damage, alleviated physiological damage in mice, and increased the expression of antioxidant genes. This suggests that the Se-enriched diet has a positive effect on biological effects in mice and can support enzymatic antioxidant systems to resist damage from low levels of Cd.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Genetics & Heredity
Paul W. Sternberg
Summary: The Alliance of Genome Resources is a collaborative effort of 7 knowledgebase projects aimed at providing better service, a harmonized view of data, and a sustainable infrastructure. It offers comparative views of gene function, gene expression, and human disease relevance. The information is presented on uniform gene pages for easy summarization.
Article
Cell Biology
Muniyandi Selvaraj, Shrikant B. Kokate, Gabriella Reggiano, Konstantin Kogan, Tommi Kotila, Elena Kremneva, Frank DiMaio, Pekka Lappalainen, Juha T. Huiskonen
Summary: The actin cytoskeleton plays a critical role in various cellular processes. Tropomyosins are important proteins that regulate actin filaments. This study reveals the molecular mechanisms of how different tropomyosin isoforms interact with actin filaments, leading to their differential functions in myosin II activation and protection against ADF/cofilin-catalyzed severing.
Article
Biochemistry & Molecular Biology
Luca Schulz, Franziska L. Sendker, Georg K. A. Hochberg
Summary: Intricate biochemical structures are generally considered useful and protected by natural selection. However, according to evolutionary theory, even useless complexity can become essential if certain evolutionary conditions are met. Evidence suggests that stable protein complexes, protein-chaperone interactions, and complexes consisting of several paralogs fulfill these conditions.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2022)
Article
Physics, Fluids & Plasmas
Xiyan Yang, Yiren Chen, Tianshou Zhou, Jiajun Zhang
Summary: Biological processes are controlled by biochemical reaction networks operating far from thermodynamic equilibrium, dissipated free energy. Single reaction events occur in a memory manner, leading to non-Markovian kinetics. By calculating the energy consumption of a general reaction system with molecular memory, it is revealed that energy dissipation is influenced by broken detailed balance and direction-time dependence of waiting-time distributions.
Article
Biochemical Research Methods
Yun Min Song, Hyukpyo Hong, Jae Kyoung Kim
Summary: Biochemical systems, characterized by numerous elementary reactions, are often described using simplified non-elementary reaction functions for stochastic simulations, which has been controversial in terms of accuracy. This study provides a framework developed based on both deterministic and stochastic properties to accurately capture the stochastic dynamics of biochemical systems. By offering an open-source computational package, ASSISTER, accurate and efficient simulations of multiscale biochemical systems are made possible.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oceanography
Chen Wang, Lingling Kong, Shanshan Lian, Zujing Yang, Deting Meng, Moli Li, Xiangchao Zhang, Zhenmin Bao, Xiaoli Hu
Summary: A better understanding of the genetic regulation of growth is crucial for improving the yield of commercially important bivalves. By using the dwarf surf clam as a model organism, this study characterizes and verifies the function of the E2F3 gene in growth regulation. The results demonstrate the potential of the dwarf surf clam as a model organism for investigating gene functions in commercial bivalves, shedding light on the genetic causes of growth variation to enhance bivalve farming efficiency.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2023)
Article
Pharmacology & Pharmacy
Nidhi Raval, Piyush Gondaliya, Vishakha Tambe, Kiran Kalia, Rakesh K. Tekade
Summary: miRNA-30a plays a crucial role in diabetic nephropathy, and delivering miRNA-30a mimic through specific and efficient pathways may alleviate podocyte pathologies. The downregulation of miRNA-30a expression in diabetic nephropathy patients can be restored using specific nanoparticles, reducing glomerular diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Alina Nicheperovich, Adrian M. Altenhoff, Christophe Dessimoz, Sina Majidian
Summary: Conservation of pathways and genes across species has allowed scientists to use non-human model organisms to gain a deeper understanding of human biology. The use of traditional model systems such as mice, rats, and zebrafish is costly and time-consuming, and raises ethical concerns. To address these issues, the Orthologous Matrix and Alternative Model Organism (OMAMO) software and web service provides users with the best non-complex organism for research based on orthologous relationships between humans and other species.
Article
Neurosciences
Hildur Soley Sveinsdottir, Christian Christensen, Haraldur Porsteinsson, Perrine Lavalou, Matthew O. Parker, Alena Shkumatava, William H. J. Norton, Emile Andriambeloson, Stephanie Wagner, Karl Aegir Karlsson
Summary: This study established a genetic model of ADHD in zebrafish and identified five potential non-stimulant therapeutic options. These findings provide a new tool for understanding the neural circuits and etiology of ADHD, and also discover novel treatment options.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Satish Ramakrishna
Summary: This paper discusses the measurement process of quantum states, as well as the concepts of dephasing, decoherence, and collapse. It explores different calculation tools and general methods for wave-function collapse. The environmental decoherence approach and consistent histories approach are two common approaches to studying wave-function collapse.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Tulio L. Campos, Pasi K. Korhonen, Andreas Hofmann, Robin B. Gasser, Neil D. Young
Summary: The development of high-quality genomes and advances in functional genomics have led to the need for innovative techniques for predicting and investigating essential genes. Machine learning approaches offer the potential to reliably predict gene importance and could be a valuable tool for biological research.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Multidisciplinary Sciences
Phaneendra Chennampally, Ambreen Sayed-Zahid, Prabakaran Soundararajan, Jocelyn Sharp, Gregory A. Cox, Scott D. Collins, Rosemary L. Smith
Summary: Research has shown that rapamycin can increase the survival rate of ALS affected motor neurons. Using a TDP-43-A315T transgenic mouse model and microfluidic technology, it was found that the survival rate of ALS affected motor neurons can be increased within a certain rapamycin dosage range.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Eyal Ben-David, James Boocock, Longhua Guo, Stefan Zdraljevic, Joshua S. Bloom, Leonid Kruglyak
Summary: Researchers developed a novel approach in the nematode Caenorhabditis elegans to map eQTLs at cellular resolution in a single experiment, revealing cell-type-specific trans eQTL hotspots that affect core pathways. Additionally, they found single-cell-specific eQTL effects in the nervous system, including an eQTL with opposite effects in two individual neurons, demonstrating that eQTL effects can be specific down to the level of single cells.
Article
Multidisciplinary Sciences
Andrzej Kasperski, Renata Kasperska
Summary: The research utilized an artificial neural network and a semi-homologous approach to investigate whether organisms during evolution are trapped in 'local' attractors, proposing a new model for cancer transformation and development that highlights the differences with normal organisms. However, there is still no definitive explanation for the initiation and development of cancer.
SCIENTIFIC REPORTS
(2021)