Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway

Alginate Oligosaccharide Ameliorates D-Galactose-Induced Kidney Aging in Mice through Activation of the Nrf2 Signaling Pathway

(2021) Hui Pan et al.   Biomed Research International

Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside

(2021) Hao Zhou et al.   AGEING RESEARCH REVIEWS

The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

(2020) Elisa B. Randi et al.   ANTIOXIDANTS & REDOX SIGNALING

Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury

(2020) Jin Wang et al.   CELL BIOLOGY AND TOXICOLOGY

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

AKAP1 mediates high glucose‐induced mitochondrial fission through the phosphorylation of Drp1 in podocytes

(2020) Zhaowei Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

(2020) Jin Wang et al.   ANGIOGENESIS

Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3

(2020) Jin Wang et al.   BIOCHEMICAL PHARMACOLOGY

Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

(2020) Fei Zhao et al.   Oxidative Medicine and Cellular Longevity

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials

(2020) Jin Wang et al.   PHARMACOLOGICAL RESEARCH

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Mitochondrial Dynamics/Mitophagy in Neurological Diseases

(2020) Tae-Cheon Kang   Antioxidants

Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction

(2020) Elena Martínez‐Klimova et al.   BIOFACTORS

Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic Kidney Disease in Mice

(2020) Brittney M. Rush et al.   KIDNEY INTERNATIONAL

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

(2020) K. J. Botting et al.   Science Advances

Mitochondrial quality control in kidney injury and repair

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy

(2019) Yiqiong Ma et al.   Endocrine Connections

Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes

(2019) Jun Feng et al.   LIFE SCIENCES

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

(2018) Ye Xi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness

(2018) Omar Emiliano Aparicio-Trejo et al.   PHARMACOLOGICAL RESEARCH

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

(2018) Qiongyuan Hu et al.   Cell Death & Disease

Role of c-Abl and nephrin in podocyte cytoskeletal remodeling induced by angiotensin II

(2018) Yiqiong Ma et al.   Cell Death & Disease

The Role for Protein Restriction in Addition to Renin-Angiotensin-Aldosterone System Inhibitors in the Management of CKD

(2018) Laetitia Koppe et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney

(2018) In-Ae Jang et al.   Nutrients

Mitochondria-Targeted Drugs

(2018) Roman A. Zinovkin et al.   Current Molecular Pharmacology

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Renin Angiotensin System and Cytokines in Chronic Kidney Disease: Clinical and Experimental Evidence

(2017) Ariadna Andrade Saldanha da Silva et al.   PROTEIN AND PEPTIDE LETTERS

Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2

(2017) Shuyi Wang et al.   TOXICOLOGY LETTERS

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

(2016) B. A. Ayanga et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3  Reinforces the Nrf2 Antioxidant Defense against Podocytopathy

(2015) S. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Renin-Angiotensin-Aldosterone System Blockade in Diabetic Nephropathy. Present Evidences

(2015) Luz Lozano-Maneiro et al.   Journal of Clinical Medicine

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice

(2013) Manchang Liu et al.   KIDNEY INTERNATIONAL

A New Era of Podocyte-Targeted Therapy for Proteinuric Kidney Disease

(2013) Börje Haraldsson   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

ANG II promotes autophagy in podocytes

(2010) Anju Yadav et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY