Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

Pharmaceutical perspective on bioactives from Alstonia scholaris: ethnomedicinal knowledge, phytochemistry, clinical status, patent space, and future directions

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“Kidney Tea” and Its Bioactive Secondary Metabolites for Treatment of Gout

(2020) Wei-Di Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats

(2020) Nomadlozi Blessings Hlophe et al.   MOLECULES

Triterpene saponins from the seeds of Erythrophleum fordii and their cytotoxic activities

(2020) Ze-Ping Chen et al.   PHYTOCHEMISTRY

Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase

(2020) Yanyu Chen et al.   PHYTOMEDICINE

Pharmacokinetics and Safety evaluation in Healthy Chinese Volunteers of Alkaloids from leaf of Alstonia scholaris, A Multiple Doses Phase I Clinical Trial

(2019) Rui Li et al.   PHYTOMEDICINE

Novel xanthine oxidase-based cell model using HK-2 cell for screening antihyperuricemic functional compounds

(2019) Chuanli Hou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition

(2019) Hua Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations

(2018) Eman Abu-Gharbieh et al.   PLoS One

Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis

(2017) Yao-Yue Fan et al.   ORGANIC LETTERS

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris

(2016) Chao-Min Wang et al.   MOLECULES

Alstoscholarisines H–J, Indole Alkaloids from Alstonia scholaris: Structural Evaluation and Bioinspired Synthesis of Alstoscholarisine H

(2016) Zhiqiang Pan et al.   ORGANIC LETTERS

Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata

(2015) Jing Wang et al.   FOOD CHEMISTRY

HIV-1 maturation inhibitors: An update

(2015) Z. Dang et al.   DRUGS OF THE FUTURE

Betaine Reduces Serum Uric Acid Levels and Improves Kidney Function in Hyperuricemic Mice

(2013) Yang-Liu Liu et al.   PLANTA MEDICA

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

(2012) Jorge A. R. Salvador et al.   NATURAL PRODUCT REPORTS

CDDO-Imidazolide Induces DNA Damage, G2/M Arrest and Apoptosis in BRCA1-Mutated Breast Cancer Cells

(2011) E.-H. Kim et al.   Cancer Prevention Research

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

(2011) Huaming Sheng et al.   NATURAL PRODUCT REPORTS

Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris

(2009) Fei Wang et al.   PHYTOCHEMISTRY