Enhancing SERS detection on a biocompatible metallic substrate for diabetes diagnosing

A method to realize surface-enhanced Raman spectroscopy (SERS) at a titanium alloy substrate for glucose detection has been experimentally demonstrated. A silver-coated laser-induced periodic surface structure (LIPSS) was prepared via femtosecond laser micro-processing. The low detection limit of glucose is 10(-7) mol/L and, a good linear relationship between the glucose concentration and Raman intensity is found in the range between 1 x 10(-7) and 1 x 10(-3) mol/L. Moreover, we investigate SERS detection for glucose sensing in human urine samples, while the results are in good agreement with clinical results. The Letter provides a facile method for producing a structure-controlled SERS substrate to realize glucose detection, which is promising for long-term in vivo diagnostics. (C) 2021 Optical Society of America

Automated summary

An experimental method for surface-enhanced Raman spectroscopy (SERS) on a titanium alloy substrate for glucose detection has been successfully demonstrated. The method involves using a silver-coated laser-induced periodic surface structure (LIPSS) created by femtosecond laser micro-processing. The detection limit for glucose is 10(-7) mol/L, with a good linear relationship between glucose concentration and Raman intensity. Additionally, the method has been applied for glucose sensing in human urine samples, showing promising results for long-term in vivo diagnostics.