期刊
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 80, 期 3, 页码 403-414出版社
WILEY
DOI: 10.1111/bcp.12686
关键词
calcitonin gene-related peptide; CGRP; migraine; mouse model; neuropeptide; photophobia
资金
- NIH [NS075599]
Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of migraine is altered sensory perception. A likely contributor to this altered perception is the neuropeptide calcitonin gene-related peptide (CGRP). Over the past decade, CGRP has become firmly established as a key player in migraine. Although the mechanisms and sites of action by which CGRP might trigger migraine remain speculative, recent advances with mouse models provide some hints. This brief review focuses on how CGRP might act as both a central and peripheral neuromodulator to contribute to the migraine-like symptom of light aversive behaviour in mice.
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