Thioredoxin reductase is a major regulator of metabolism in leukemia cells

Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in Bladder Cancer

(2019) Venkatrao Vantaku et al.   CLINICAL CANCER RESEARCH

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia

(2019) Nicolas Chapuis et al.   Frontiers in Oncology

Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update

(2018) Junmin Zhang et al.   MEDICINAL RESEARCH REVIEWS

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

(2018) William C. Stafford et al.   Science Translational Medicine

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

(2017) Dmitri Leonoudakis et al.   MEDIATORS OF INFLAMMATION

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

(2016) Sina Oppermann et al.   BLOOD

Novel securinine derivatives as topoisomerase I based antitumor agents

(2016) Wen Hou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thioredoxin reductase inhibitors: a patent review

(2016) Baoxin Zhang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

(2016) Xiaoxiao Peng et al.   Scientific Reports

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of thioredoxin reductase 1 in melanoma metabolism and metastasis

(2015) Pamela B. Cassidy et al.   Pigment Cell & Melanoma Research

Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria

(2015) Danilo M. Daloso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

(2015) J Pfleger et al.   Cell Death & Disease

Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase

(2015) Anna Kaplan et al.   ACS Medicinal Chemistry Letters

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

(2015) Ling Li et al.   Redox Biology

Targeting IDH: the next big thing in AML

(2013) M. Levis   BLOOD

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

(2013) A. Chaturvedi et al.   BLOOD

Redox Regulation of Arabidopsis Mitochondrial Citrate Synthase

(2013) Elisabeth Schmidtmann et al.   Molecular Plant

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

(2012) W. C. Reinhold et al.   CANCER RESEARCH

Proteomic and Systems Biology Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant

(2012) Matt Shipman et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Susceptibility of the Antioxidant Selenoenyzmes Thioredoxin Reductase and Glutathione Peroxidase to Alkylation-Mediated Inhibition by Anticancer Acylfulvenes

(2011) Xiaodan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML

(2011) Kalpana Gupta et al.   PLoS One

Crystal structure of the human thioredoxin reductase–thioredoxin complex

(2011) Karin Fritz-Wolf et al.   Nature Communications

Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells

(2010) Sonia Rana et al.   FASEB JOURNAL

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA