Be cool to be far: Exploiting hibernation for space exploration

In mammals, torpor/hibernation is a state that is characterized by an active reduction in metabolic rate followed by a progressive decrease in body temperature. Torpor was successfully mimicked in non-hibernators by inhibiting the activity of neurons within the brainstem region of the Raphe Pallidus, or by activating the adenosine A1 receptors in the brain. This state, called synthetic torpor, may be exploited for many medical applications, and for space exploration, providing many benefits for biological adaptation to the space environment, among which an enhanced protection from cosmic rays. As regards the use of synthetic torpor in space, to fully evaluate the degree of physiological advantage provided by this state, it is strongly advisable to move from Earth-based experiments to 'in the field' tests, possibly on board the International Space Station.

Automated summary

Torpor/hibernation in mammals involves a reduction in metabolic rate and body temperature, which can also be induced in non-hibernating animals by manipulating brainstem neurons or activating adenosine A1 receptors. This synthetic torpor state has potential applications in medicine and space exploration, offering benefits for biological adaptation to space environments and increased protection from cosmic rays. Further testing 'in the field', possibly on the International Space Station, is recommended to fully understand the physiological advantages of synthetic torpor in space.